Impaired IgM Memory B Cell Function Is Common in Coeliac Disease but Conjugate Pneumococcal Vaccination Induces Robust Protective Immunity

Impaired IgM Memory B Cell Function Is Common in Coeliac Disease but Conjugate Pneumococcal Vaccination Induces Robust Protective Immunity

Coeliac disease (CD) is associated with hyposplenism, an acquired impairment of spleen function associated with reduced IgM memory B cells and increased susceptibility to serious pneumococcal infection. Little is known about the immune implications of hyposplenism in CD or the optimal pneumococcal v...

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Bibliographic Details
Main Authors: Olivia G. Moscatelli, Amy K. Russell, Lee M. Henneken, Melinda Y. Hardy, Nadia Mazarakis, Rachel Higgins, Jesse Ekin, Harry McLeod, Paul Simkin, Paul V. Licciardi, Vanessa L. Bryant, Jason A. Tye-Din
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Vaccines
Subjects:
coeliac disease
IgM memory B cells
hyposplenism
pneumococcal vaccination
Online Access:https://www.mdpi.com/2076-393X/12/2/214

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