Prevalence and clinical relevance of liver dysfunction after thoracic surgery: a retrospective study
Abstract Postoperative elevation of serum aminotransferase or alkaline phosphatase levels after liver and heart surgeries has been widely reported. The prevalence and clinical significance of hypertransaminasemia/liver dysfunction after thoracic surgery remains largely unknown. Significant differenc...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-49427-0 |
| _version_ | 1827394655656869888 |
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| author | Rosanna Villani Domenico Loizzi Antonia Federica Sacco Lucia Mirabella Mariateresa Santoliquido Diletta Mongiello Francesco Sollitto Gaetano Serviddio |
| author_facet | Rosanna Villani Domenico Loizzi Antonia Federica Sacco Lucia Mirabella Mariateresa Santoliquido Diletta Mongiello Francesco Sollitto Gaetano Serviddio |
| author_sort | Rosanna Villani |
| collection | DOAJ |
| description | Abstract Postoperative elevation of serum aminotransferase or alkaline phosphatase levels after liver and heart surgeries has been widely reported. The prevalence and clinical significance of hypertransaminasemia/liver dysfunction after thoracic surgery remains largely unknown. Significant differences in surgical procedures between thoracic and extra-thoracic surgeries may suggest different risks of liver dysfunction. We retrospectively analyzed data from 224 consecutive patients who underwent thoracic surgery. Liver function tests were recorded the day before surgery, 12 h, 1 day, 5, and 10 days after the surgical procedure. Patients were studied to identify the frequency of hypertransaminasemia and/or hyperbilirubinemia and/or increase of INR levels. 37,5% of patients showed an increase in serum alanine aminotransferase (ALT) level after thoracic surgery, whereas an increase in gamma glutamyl transferase (GGT) serum levels of any grade was observed in 53,6% of patients. Approximately 83% of patients who experienced an increase in the serum GGT or ALT levels showed a grade 1 or 2 change. Operative time was associated with hypertransaminasemia in the univariate and multivariate analyses, whereas the use of metformin was associated with a lower risk of ALT increase. |
| first_indexed | 2024-03-08T18:16:05Z |
| format | Article |
| id | doaj.art-e17d91f30fab4023a3ac04fdead7bd55 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T18:16:05Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e17d91f30fab4023a3ac04fdead7bd552023-12-31T12:11:05ZengNature PortfolioScientific Reports2045-23222023-12-0113111010.1038/s41598-023-49427-0Prevalence and clinical relevance of liver dysfunction after thoracic surgery: a retrospective studyRosanna Villani0Domenico Loizzi1Antonia Federica Sacco2Lucia Mirabella3Mariateresa Santoliquido4Diletta Mongiello5Francesco Sollitto6Gaetano Serviddio7C.U.R.E. (University Center for Liver Disease Research and Treatment), Liver Unit, Department of Medical and Surgical Sciences, University of FoggiaInstitute of Thoracic Surgery, Department of Medical and Surgical Sciences, University of FoggiaC.U.R.E. (University Center for Liver Disease Research and Treatment), Liver Unit, Department of Medical and Surgical Sciences, University of FoggiaAnesthesia and Intensive Care Unit, Department of Medical and Surgical Sciences, University of FoggiaC.U.R.E. (University Center for Liver Disease Research and Treatment), Liver Unit, Department of Medical and Surgical Sciences, University of FoggiaInstitute of Thoracic Surgery, Department of Medical and Surgical Sciences, University of FoggiaInstitute of Thoracic Surgery, Department of Medical and Surgical Sciences, University of FoggiaC.U.R.E. (University Center for Liver Disease Research and Treatment), Liver Unit, Department of Medical and Surgical Sciences, University of FoggiaAbstract Postoperative elevation of serum aminotransferase or alkaline phosphatase levels after liver and heart surgeries has been widely reported. The prevalence and clinical significance of hypertransaminasemia/liver dysfunction after thoracic surgery remains largely unknown. Significant differences in surgical procedures between thoracic and extra-thoracic surgeries may suggest different risks of liver dysfunction. We retrospectively analyzed data from 224 consecutive patients who underwent thoracic surgery. Liver function tests were recorded the day before surgery, 12 h, 1 day, 5, and 10 days after the surgical procedure. Patients were studied to identify the frequency of hypertransaminasemia and/or hyperbilirubinemia and/or increase of INR levels. 37,5% of patients showed an increase in serum alanine aminotransferase (ALT) level after thoracic surgery, whereas an increase in gamma glutamyl transferase (GGT) serum levels of any grade was observed in 53,6% of patients. Approximately 83% of patients who experienced an increase in the serum GGT or ALT levels showed a grade 1 or 2 change. Operative time was associated with hypertransaminasemia in the univariate and multivariate analyses, whereas the use of metformin was associated with a lower risk of ALT increase.https://doi.org/10.1038/s41598-023-49427-0 |
| spellingShingle | Rosanna Villani Domenico Loizzi Antonia Federica Sacco Lucia Mirabella Mariateresa Santoliquido Diletta Mongiello Francesco Sollitto Gaetano Serviddio Prevalence and clinical relevance of liver dysfunction after thoracic surgery: a retrospective study Scientific Reports |
| title | Prevalence and clinical relevance of liver dysfunction after thoracic surgery: a retrospective study |
| title_full | Prevalence and clinical relevance of liver dysfunction after thoracic surgery: a retrospective study |
| title_fullStr | Prevalence and clinical relevance of liver dysfunction after thoracic surgery: a retrospective study |
| title_full_unstemmed | Prevalence and clinical relevance of liver dysfunction after thoracic surgery: a retrospective study |
| title_short | Prevalence and clinical relevance of liver dysfunction after thoracic surgery: a retrospective study |
| title_sort | prevalence and clinical relevance of liver dysfunction after thoracic surgery a retrospective study |
| url | https://doi.org/10.1038/s41598-023-49427-0 |
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