BMP2 secretion from hepatocellular carcinoma cell HepG2 enhances angiogenesis and tumor growth in endothelial cells via activation of the MAPK/p38 signaling pathway

BMP2 secretion from hepatocellular carcinoma cell HepG2 enhances angiogenesis and tumor growth in endothelial cells via activation of the MAPK/p38 signaling pathway

Abstract Background Hepatocellular carcinoma (HCC) is one of the most common tumors globally, with varying prevalence based on endemic risk factors. Bone morphogenetic protein (BMP) exhibits a broad spectrum of biological activities in various tissues including angiogenesis. Here, this study aimed t...

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Bibliographic Details
Main Authors: Peng-Cheng Feng, Xing-Fei Ke, Hui-Lan Kuang, Li-Li Pan, Qiang Ye, Jian-Bing Wu
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Stem Cell Research & Therapy
Subjects:
BMP2
MAPK/p38 signaling pathway
Tumor growth
Angiogenesis
Hepatocellular carcinoma
Online Access:http://link.springer.com/article/10.1186/s13287-019-1301-2

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