Summary: | Recent study in humans and animal has been focused on inflammatory biomarkers that infectious diseases, such as serum amyloid A (SAA),
procalcitonin (PCT), that may more accurately and efficiently diagnose inflammation. The aim of this study was to evaluate SAA and PCT
levels in the diagnosis of cattle with inflammatory disease. Ten healthy control cattle and 64 patients with systemic inflammatory response
syndrome (SIRS) were included in cattle. Inflammatory disease in cattle was diagnosed based on clinical signs and the laboratory examination
in clinically suspected cases. SAA and PCT concentrations were measured with a commercial ELISA assay for cattle. SAA and PCT concentrations
in cattle with inflammatory disease were significantly higher than in the healthy controls (respectively, P<0.001, P<0.008). Concentrations of
SAA and PCT at admission were significantly (r = 0.376, P<0.01) correlated with outcome in cattle with inflammatory conditions. The cut-off
value of SAA and PCT for healthy and inflammatory cattle was determined 28.52 μg/mL and 149.55 pg/mL. In conclusion, PCT levels may be
used as an alternative to serum SAA measurement as an indicator of acute inflammation in cattle. Serum PCT concentrations were ~9 times
higher in the cattle with peritonitis than in the healthy cattle, suggesting that PCT could be a useful marker of peritonitis in cattle.
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