Synthesis of Trifluoromethylated Pyrimido[1,2-<i>b</i>]indazole Derivatives through the Cyclocondensation of 3-Aminoindazoles with Ketoester and Their Functionalization via Suzuki-Miyaura Cross-Coupling and SN<sub>Ar</sub> Reactions
A new series of trifluoromethylated pyrimido[1,2-<i>b</i>]indazol-4(1<i>H</i>)-one derivatives was synthesized with good to excellent yields through a simple condensation of 3-aminoindazole derivatives with ethyl 4,4,4-trifluoro 3-oxobutanoate. The functionalization of the co...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/29/1/44 |
| Summary: | A new series of trifluoromethylated pyrimido[1,2-<i>b</i>]indazol-4(1<i>H</i>)-one derivatives was synthesized with good to excellent yields through a simple condensation of 3-aminoindazole derivatives with ethyl 4,4,4-trifluoro 3-oxobutanoate. The functionalization of the corresponding chlorinated fused tricyclic scaffolds via Suzuki-Miyaura and aromatic nucleophilic substitution reactions led to the synthesis of highly diverse trifluoromethylated pyrimido[1,2-<i>b</i>]indazole derivatives with good yields. |
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| ISSN: | 1420-3049 |