Synthesis of Trifluoromethylated Pyrimido[1,2-<i>b</i>]indazole Derivatives through the Cyclocondensation of 3-Aminoindazoles with Ketoester and Their Functionalization via Suzuki-Miyaura Cross-Coupling and SN<sub>Ar</sub> Reactions

Synthesis of Trifluoromethylated Pyrimido[1,2-<i>b</i>]indazole Derivatives through the Cyclocondensation of 3-Aminoindazoles with Ketoester and Their Functionalization via Suzuki-Miyaura Cross-Coupling and SN<sub>Ar</sub> Reactions

A new series of trifluoromethylated pyrimido[1,2-<i>b</i>]indazol-4(1<i>H</i>)-one derivatives was synthesized with good to excellent yields through a simple condensation of 3-aminoindazole derivatives with ethyl 4,4,4-trifluoro 3-oxobutanoate. The functionalization of the co...

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Bibliographic Details
Main Authors: Sakina Tellal, Badr Jismy, Djamila Hikem-Oukacha, Mohamed Abarbri
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Molecules
Subjects:
3-aminoindazole derivatives
ethyl 4,4,4-trifluoro 3-oxobutanoate
Suzuki-Miyaura cross-coupling
SN<sub>Ar</sub>
trifluoromethylated pyrimido[1,2-<i>b</i>]indazole derivatives
Online Access:https://www.mdpi.com/1420-3049/29/1/44

Internet

https://www.mdpi.com/1420-3049/29/1/44

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