Test-system for the assessment of GSK-3 inhibitors activity as antihypoxants and endothelial differentiation stimulators <i>in vitro</i>
The present article describes the stages of the development of the test-system that allows to research the potency of GSK-3 inhibitors to induce endothelial progenitor differentiation and to increase cell survival in hypoxia in vitro. β4-thymosin, which shows anti-ischemic and angiogenic activity, h...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)
2018-02-01
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| Series: | Регуляторные исследования и экспертиза лекарственных средств |
| Subjects: | |
| Online Access: | https://www.vedomostincesmp.ru/jour/article/view/10 |
| _version_ | 1826566793796255744 |
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| author | Yu. E. Burda S. V. Nadezhdin E. V. Zubareva M. V. Pokrovsky S. Yu. Burda M. S. Shirina |
| author_facet | Yu. E. Burda S. V. Nadezhdin E. V. Zubareva M. V. Pokrovsky S. Yu. Burda M. S. Shirina |
| author_sort | Yu. E. Burda |
| collection | DOAJ |
| description | The present article describes the stages of the development of the test-system that allows to research the potency of GSK-3 inhibitors to induce endothelial progenitor differentiation and to increase cell survival in hypoxia in vitro. β4-thymosin, which shows anti-ischemic and angiogenic activity, has been used a reference preparation. The proposed experimental cell model can be useful in the preliminary testing of new chemical compounds in terms of their ability to treat ischemic disorders and it can be used as an alternative for procedures involving animal testing. |
| first_indexed | 2024-03-07T19:18:32Z |
| format | Article |
| id | doaj.art-e18472b7bc39469683b5cb18300251e4 |
| institution | Directory Open Access Journal |
| issn | 3034-3062 3034-3453 |
| language | Russian |
| last_indexed | 2025-03-14T10:57:18Z |
| publishDate | 2018-02-01 |
| publisher | Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) |
| record_format | Article |
| series | Регуляторные исследования и экспертиза лекарственных средств |
| spelling | doaj.art-e18472b7bc39469683b5cb18300251e42025-03-02T10:46:38ZrusFederal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)Регуляторные исследования и экспертиза лекарственных средств3034-30623034-34532018-02-010129328Test-system for the assessment of GSK-3 inhibitors activity as antihypoxants and endothelial differentiation stimulators <i>in vitro</i>Yu. E. Burda0S. V. Nadezhdin1E. V. Zubareva2M. V. Pokrovsky3S. Yu. Burda4M. S. Shirina5Belgorod State National Research UniversityBelgorod State National Research UniversityBelgorod State National Research UniversityBelgorod State National Research UniversityKursk State Medical UniversityBelgorod State National Research UniversityThe present article describes the stages of the development of the test-system that allows to research the potency of GSK-3 inhibitors to induce endothelial progenitor differentiation and to increase cell survival in hypoxia in vitro. β4-thymosin, which shows anti-ischemic and angiogenic activity, has been used a reference preparation. The proposed experimental cell model can be useful in the preliminary testing of new chemical compounds in terms of their ability to treat ischemic disorders and it can be used as an alternative for procedures involving animal testing.https://www.vedomostincesmp.ru/jour/article/view/10киназа гликогенсинтазы-3gsk-3β4-тимозингипоксияишемияэндотелийglycogen synthase kinase 3gsk-3β4-thymosinhypoxiaischemiaendothelium |
| spellingShingle | Yu. E. Burda S. V. Nadezhdin E. V. Zubareva M. V. Pokrovsky S. Yu. Burda M. S. Shirina Test-system for the assessment of GSK-3 inhibitors activity as antihypoxants and endothelial differentiation stimulators <i>in vitro</i> Регуляторные исследования и экспертиза лекарственных средств киназа гликогенсинтазы-3 gsk-3 β4-тимозин гипоксия ишемия эндотелий glycogen synthase kinase 3 gsk-3 β4-thymosin hypoxia ischemia endothelium |
| title | Test-system for the assessment of GSK-3 inhibitors activity as antihypoxants and endothelial differentiation stimulators <i>in vitro</i> |
| title_full | Test-system for the assessment of GSK-3 inhibitors activity as antihypoxants and endothelial differentiation stimulators <i>in vitro</i> |
| title_fullStr | Test-system for the assessment of GSK-3 inhibitors activity as antihypoxants and endothelial differentiation stimulators <i>in vitro</i> |
| title_full_unstemmed | Test-system for the assessment of GSK-3 inhibitors activity as antihypoxants and endothelial differentiation stimulators <i>in vitro</i> |
| title_short | Test-system for the assessment of GSK-3 inhibitors activity as antihypoxants and endothelial differentiation stimulators <i>in vitro</i> |
| title_sort | test system for the assessment of gsk 3 inhibitors activity as antihypoxants and endothelial differentiation stimulators i in vitro i |
| topic | киназа гликогенсинтазы-3 gsk-3 β4-тимозин гипоксия ишемия эндотелий glycogen synthase kinase 3 gsk-3 β4-thymosin hypoxia ischemia endothelium |
| url | https://www.vedomostincesmp.ru/jour/article/view/10 |
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