A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis

A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis

Pulmonary fibrosis (PF) is a pathological change caused by repeated injuries and repair dysfunction of the alveolar epithelium. Our previous study revealed that the residues Asn3 and Asn4 of peptide DR8 (DHNNPQIR-NH2) could be modified to improve stability and antifibrotic activity, and the unnatura...

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Bibliographic Details
Main Authors: Dan Wang, Bochuan Deng, Lu Cheng, Jieru Li, Jiao Zhang, Xiang Zhang, Xiaomin Guo, Tiantian Yan, Xin Yue, Yingying An, Bangzhi Zhang, Wenle Yang, Junqiu Xie, Rui Wang
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Peptide
Structure modification
Pulmonary fibrosis
miR-23b-5p
AQP5
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522003896

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