Prevalence and associations of dry eye disease and meibomian gland dysfunction in the ural eye and medical study
Abstract To assess the prevalence of dry eye disease (DED) and Meibomian gland dysfunction (MGD) in a population in Russia. The population-based Ural Eye and Medical Study was conducted in an urban and rural region in Bashkortostan/Russia and included 5899 (80.5%) out of 7328 eligible persons, aged...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-22580-8 |
| _version_ | 1828329947451621376 |
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| author | Mukharram M. Bikbov Timur R. Gilmanshin Rinat M. Zainullin Gyulli M. Kazakbaeva Ellina M. Iakupova Albina A. Fakhretdinova Azaliia M. Tuliakova Songhomitra Panda-Jonas Iuliia A. Rusakova Ildar F. Nuriev Artur F. Zaynetdinov Liana A. Miniazeva Jost B. Jonas |
| author_facet | Mukharram M. Bikbov Timur R. Gilmanshin Rinat M. Zainullin Gyulli M. Kazakbaeva Ellina M. Iakupova Albina A. Fakhretdinova Azaliia M. Tuliakova Songhomitra Panda-Jonas Iuliia A. Rusakova Ildar F. Nuriev Artur F. Zaynetdinov Liana A. Miniazeva Jost B. Jonas |
| author_sort | Mukharram M. Bikbov |
| collection | DOAJ |
| description | Abstract To assess the prevalence of dry eye disease (DED) and Meibomian gland dysfunction (MGD) in a population in Russia. The population-based Ural Eye and Medical Study was conducted in an urban and rural region in Bashkortostan/Russia and included 5899 (80.5%) out of 7328 eligible persons, aged 40 + years. DED and MGD were assessed by Schirmer´s test, slit-lamp based examination of the Meibomian glands, and an interview with DED-related questions. The study included 5153 (87.4%) individuals with DED and MGD assessments (mean age: 58.5 ± 10.5 years). The mean Schirmer´s test result was 11.8 ± 6.8 mm and 12.5 ± 7.1 mm for the right/left eye, with a result of ≤ 5 mm measured in 1098 (21.3%; 95% confidence intervals (CI) 20.2, 22.4) of the worse eyes. The mean subjective dry eye symptoms score was 1.37 ± 1.82. MGD grade 1 (telangiectasia at the lid margin), 2, 3, 4 or any grade in the worse eye was diagnosed in 901 (21.1%), 1161 (27.1%), 158 (3.7%), 32 (0.7%), and 2252 (52.6%; 95% CI 51.1, 54.1) eyes respectively. The prevalence of DED diagnosis #1, #2 and #3 (Schirmer´s test ≤ 5 mm, and dry eye score ≥ 1, ≥ 2, and ≥ 3, respectively), #4 (dry eye score ≥ 1, Schirmer test ≤ 5 mm, MGD grade 1 +), and #5 (dry eye score ≥ 1, Schirmer test ≤ 5 mm, MGD grade 2 +) were 598/5142 (11.6%), 426/5153 (8.3%), 273/5142 (5.3%), 335/5142 (6.5%), and 186/5142 (3.6%), respectively. Mean depression score as applied was 5.1 ± 3.8. Higher DED prevalence (definition #4) was associated (multivariable analysis) with female sex (odds ratio (OR) 1.71; 95% CI 1.31, 2.22; P < 0.001), higher depression score (OR 1.04; 95% CI 101, 1.07; P = 0.009), and higher prevalence of thyroid disease history (OR 1.63; 95% CI 1.19, 2.24; P = 0.006). DED and MGD were common in this rural and urban population, and their prevalence was associated with female sex, thyroid disease, and depression. |
| first_indexed | 2024-04-13T20:32:49Z |
| format | Article |
| id | doaj.art-e186511fdd2e460f82a30cd2ea6e5f9e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T20:32:49Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e186511fdd2e460f82a30cd2ea6e5f9e2022-12-22T02:31:08ZengNature PortfolioScientific Reports2045-23222022-11-0112111410.1038/s41598-022-22580-8Prevalence and associations of dry eye disease and meibomian gland dysfunction in the ural eye and medical studyMukharram M. Bikbov0Timur R. Gilmanshin1Rinat M. Zainullin2Gyulli M. Kazakbaeva3Ellina M. Iakupova4Albina A. Fakhretdinova5Azaliia M. Tuliakova6Songhomitra Panda-Jonas7Iuliia A. Rusakova8Ildar F. Nuriev9Artur F. Zaynetdinov10Liana A. Miniazeva11Jost B. Jonas12Ufa Eye Research InstituteUfa Eye Research InstituteUfa Eye Research InstituteUfa Eye Research InstituteUfa Eye Research InstituteUfa Eye Research InstituteUfa Eye Research InstitutePrivatpraxis Prof Jonas und Dr Panda-JonasUfa Eye Research InstituteUfa Eye Research InstituteUfa Eye Research InstituteUfa Eye Research InstitutePrivatpraxis Prof Jonas und Dr Panda-JonasAbstract To assess the prevalence of dry eye disease (DED) and Meibomian gland dysfunction (MGD) in a population in Russia. The population-based Ural Eye and Medical Study was conducted in an urban and rural region in Bashkortostan/Russia and included 5899 (80.5%) out of 7328 eligible persons, aged 40 + years. DED and MGD were assessed by Schirmer´s test, slit-lamp based examination of the Meibomian glands, and an interview with DED-related questions. The study included 5153 (87.4%) individuals with DED and MGD assessments (mean age: 58.5 ± 10.5 years). The mean Schirmer´s test result was 11.8 ± 6.8 mm and 12.5 ± 7.1 mm for the right/left eye, with a result of ≤ 5 mm measured in 1098 (21.3%; 95% confidence intervals (CI) 20.2, 22.4) of the worse eyes. The mean subjective dry eye symptoms score was 1.37 ± 1.82. MGD grade 1 (telangiectasia at the lid margin), 2, 3, 4 or any grade in the worse eye was diagnosed in 901 (21.1%), 1161 (27.1%), 158 (3.7%), 32 (0.7%), and 2252 (52.6%; 95% CI 51.1, 54.1) eyes respectively. The prevalence of DED diagnosis #1, #2 and #3 (Schirmer´s test ≤ 5 mm, and dry eye score ≥ 1, ≥ 2, and ≥ 3, respectively), #4 (dry eye score ≥ 1, Schirmer test ≤ 5 mm, MGD grade 1 +), and #5 (dry eye score ≥ 1, Schirmer test ≤ 5 mm, MGD grade 2 +) were 598/5142 (11.6%), 426/5153 (8.3%), 273/5142 (5.3%), 335/5142 (6.5%), and 186/5142 (3.6%), respectively. Mean depression score as applied was 5.1 ± 3.8. Higher DED prevalence (definition #4) was associated (multivariable analysis) with female sex (odds ratio (OR) 1.71; 95% CI 1.31, 2.22; P < 0.001), higher depression score (OR 1.04; 95% CI 101, 1.07; P = 0.009), and higher prevalence of thyroid disease history (OR 1.63; 95% CI 1.19, 2.24; P = 0.006). DED and MGD were common in this rural and urban population, and their prevalence was associated with female sex, thyroid disease, and depression.https://doi.org/10.1038/s41598-022-22580-8 |
| spellingShingle | Mukharram M. Bikbov Timur R. Gilmanshin Rinat M. Zainullin Gyulli M. Kazakbaeva Ellina M. Iakupova Albina A. Fakhretdinova Azaliia M. Tuliakova Songhomitra Panda-Jonas Iuliia A. Rusakova Ildar F. Nuriev Artur F. Zaynetdinov Liana A. Miniazeva Jost B. Jonas Prevalence and associations of dry eye disease and meibomian gland dysfunction in the ural eye and medical study Scientific Reports |
| title | Prevalence and associations of dry eye disease and meibomian gland dysfunction in the ural eye and medical study |
| title_full | Prevalence and associations of dry eye disease and meibomian gland dysfunction in the ural eye and medical study |
| title_fullStr | Prevalence and associations of dry eye disease and meibomian gland dysfunction in the ural eye and medical study |
| title_full_unstemmed | Prevalence and associations of dry eye disease and meibomian gland dysfunction in the ural eye and medical study |
| title_short | Prevalence and associations of dry eye disease and meibomian gland dysfunction in the ural eye and medical study |
| title_sort | prevalence and associations of dry eye disease and meibomian gland dysfunction in the ural eye and medical study |
| url | https://doi.org/10.1038/s41598-022-22580-8 |
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