Increased Blood Concentrations of Malondialdehyde in <i>Plasmodium</i> Infection: A Systematic Review and Meta-Analysis
Several studies have evaluated the relationship between malondialdehyde (MDA) concentrations and <i>Plasmodium</i> infections; however, the findings remain inconclusive. This study synthesized differences in MDA concentrations among patients with different levels of clinical severity, un...
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MDPI AG
2023-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/8/1502 |
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| author | Onchuma Mueangson Aongart Mahittikorn Nsoh Godwin Anabire Wanida Mala Manas Kotepui |
| author_facet | Onchuma Mueangson Aongart Mahittikorn Nsoh Godwin Anabire Wanida Mala Manas Kotepui |
| author_sort | Onchuma Mueangson |
| collection | DOAJ |
| description | Several studies have evaluated the relationship between malondialdehyde (MDA) concentrations and <i>Plasmodium</i> infections; however, the findings remain inconclusive. This study synthesized differences in MDA concentrations among patients with different levels of clinical severity, uninfected controls, and different <i>Plasmodium</i> species. The research protocol was registered in PROSPERO (CRD42023393540). Systematic literature searches for relevant studies were performed using the Embase, MEDLINE, Ovid, ProQuest, PubMed, Scopus, and Google Scholar databases. Qualitative and quantitative syntheses (meta-analyses) of distinct MDA concentrations between the disease groups were performed. Twenty-three studies met the eligibility criteria and were included in the systematic review. Overall, MDA concentrations were significantly elevated in participants with malaria relative to uninfected controls (<i>p</i> < 0.01, Cohen d: 2.51, 95% confidence interval (CI): 1.88–3.14, I<sup>2</sup>: 96.22%, 14 studies). Increased MDA concentrations in participants with malaria compared with uninfected controls were found in studies that enrolled patients with <i>P. falciparum</i> malaria (<i>p</i> < 0.01, Cohen d: 2.50, 95% CI: 1.90–3.10, I<sup>2</sup>: 89.7%, 7 studies) and <i>P. vivax</i> malaria (<i>p</i> < 0.01, Cohen d: 3.70, 95% CI: 2.48–4.92, I<sup>2</sup>: 90.11%, 3 studies). Our findings confirm that MDA concentrations increase during <i>Plasmodium</i> infection, indicating a rise in oxidative stress and lipid peroxidation. Thus, MDA levels can be a valuable biomarker for evaluating these processes in individuals with malaria. However, further research is necessary to fully elucidate the intricate relationship between malaria, antioxidants, oxidative stress, and the specific role of MDA in the progression of malaria. |
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| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T00:11:00Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-e1868d017c91498db04ede7de469c7c12023-11-19T00:00:47ZengMDPI AGAntioxidants2076-39212023-07-01128150210.3390/antiox12081502Increased Blood Concentrations of Malondialdehyde in <i>Plasmodium</i> Infection: A Systematic Review and Meta-AnalysisOnchuma Mueangson0Aongart Mahittikorn1Nsoh Godwin Anabire2Wanida Mala3Manas Kotepui4School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat 80160, ThailandDepartment of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, ThailandDepartment of Biochemistry and Molecular Medicine, School of Medicine, University for Development Studies, Tamale P.O. Box TL1350, GhanaSchool of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat 80160, ThailandSchool of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat 80160, ThailandSeveral studies have evaluated the relationship between malondialdehyde (MDA) concentrations and <i>Plasmodium</i> infections; however, the findings remain inconclusive. This study synthesized differences in MDA concentrations among patients with different levels of clinical severity, uninfected controls, and different <i>Plasmodium</i> species. The research protocol was registered in PROSPERO (CRD42023393540). Systematic literature searches for relevant studies were performed using the Embase, MEDLINE, Ovid, ProQuest, PubMed, Scopus, and Google Scholar databases. Qualitative and quantitative syntheses (meta-analyses) of distinct MDA concentrations between the disease groups were performed. Twenty-three studies met the eligibility criteria and were included in the systematic review. Overall, MDA concentrations were significantly elevated in participants with malaria relative to uninfected controls (<i>p</i> < 0.01, Cohen d: 2.51, 95% confidence interval (CI): 1.88–3.14, I<sup>2</sup>: 96.22%, 14 studies). Increased MDA concentrations in participants with malaria compared with uninfected controls were found in studies that enrolled patients with <i>P. falciparum</i> malaria (<i>p</i> < 0.01, Cohen d: 2.50, 95% CI: 1.90–3.10, I<sup>2</sup>: 89.7%, 7 studies) and <i>P. vivax</i> malaria (<i>p</i> < 0.01, Cohen d: 3.70, 95% CI: 2.48–4.92, I<sup>2</sup>: 90.11%, 3 studies). Our findings confirm that MDA concentrations increase during <i>Plasmodium</i> infection, indicating a rise in oxidative stress and lipid peroxidation. Thus, MDA levels can be a valuable biomarker for evaluating these processes in individuals with malaria. However, further research is necessary to fully elucidate the intricate relationship between malaria, antioxidants, oxidative stress, and the specific role of MDA in the progression of malaria.https://www.mdpi.com/2076-3921/12/8/1502malondialdehydeMDAlipid peroxidationoxidantantioxidantmalaria |
| spellingShingle | Onchuma Mueangson Aongart Mahittikorn Nsoh Godwin Anabire Wanida Mala Manas Kotepui Increased Blood Concentrations of Malondialdehyde in <i>Plasmodium</i> Infection: A Systematic Review and Meta-Analysis Antioxidants malondialdehyde MDA lipid peroxidation oxidant antioxidant malaria |
| title | Increased Blood Concentrations of Malondialdehyde in <i>Plasmodium</i> Infection: A Systematic Review and Meta-Analysis |
| title_full | Increased Blood Concentrations of Malondialdehyde in <i>Plasmodium</i> Infection: A Systematic Review and Meta-Analysis |
| title_fullStr | Increased Blood Concentrations of Malondialdehyde in <i>Plasmodium</i> Infection: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Increased Blood Concentrations of Malondialdehyde in <i>Plasmodium</i> Infection: A Systematic Review and Meta-Analysis |
| title_short | Increased Blood Concentrations of Malondialdehyde in <i>Plasmodium</i> Infection: A Systematic Review and Meta-Analysis |
| title_sort | increased blood concentrations of malondialdehyde in i plasmodium i infection a systematic review and meta analysis |
| topic | malondialdehyde MDA lipid peroxidation oxidant antioxidant malaria |
| url | https://www.mdpi.com/2076-3921/12/8/1502 |
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