Honokiol Affects Stem Cell Viability by Suppressing Oncogenic YAP1 Function to Inhibit Colon Tumorigenesis

Honokiol Affects Stem Cell Viability by Suppressing Oncogenic YAP1 Function to Inhibit Colon Tumorigenesis

Honokiol (HNK) is a biphenolic compound that has been used in traditional medicine for treating various ailments, including cancers. In this study, we determined the effect of HNK on colon cancer cells in culture and in a colitis-associated cancer model. HNK treatment inhibited proliferation and col...

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Bibliographic Details
Main Authors: Dharmalingam Subramaniam, Sivapriya Ponnurangam, Satish Ramalingam, Deep Kwatra, Prasad Dandawate, Scott J. Weir, Shahid Umar, Roy A. Jensen, Shrikant Anant
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
apoptosis
cancer stem cells
colonospheres
spheroids
colitis associated cancer
hippo signaling
Online Access:https://www.mdpi.com/2073-4409/10/7/1607

Internet

https://www.mdpi.com/2073-4409/10/7/1607

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