Effects of nucleotides administration on growth performance and immune response of post-weaning piglets
The aim of this study was to assess the effect of nucleotides administration on growth performance and immune response in post-weaning piglets. Twenty-eight male weaned piglets, homogeneous for age and weight were randomly allocated to two experimental treatments. Treated group (T) was daily orally...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-12-01
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| Series: | Italian Journal of Animal Science |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/1828051X.2020.1738966 |
| _version_ | 1818657649939447808 |
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| author | Vera Perricone Marcello Comi Valentino Bontempo Cristina Lecchi Fabrizio Ceciliani Maurizio Crestani Alessandra Ferrari Giovanni Savoini Alessandro Agazzi |
| author_facet | Vera Perricone Marcello Comi Valentino Bontempo Cristina Lecchi Fabrizio Ceciliani Maurizio Crestani Alessandra Ferrari Giovanni Savoini Alessandro Agazzi |
| author_sort | Vera Perricone |
| collection | DOAJ |
| description | The aim of this study was to assess the effect of nucleotides administration on growth performance and immune response in post-weaning piglets. Twenty-eight male weaned piglets, homogeneous for age and weight were randomly allocated to two experimental treatments. Treated group (T) was daily orally administered 0.8 g/head of a mixture of nucleotides suspended in 2.1 mL water solution; while control group (C) received 2.1 mL saline solution. Body weight (BW) and average daily gain (ADG) were individually recorded weekly, while feed intake (FI), and gain:feed (G:F) were recorded and calculated on pen basis. Faecal score was evaluated every seven days. On day 0, 9, 18 and 27 blood samples were collected to determine IgA, IgG and haptoglobin concentration. At day 28 all piglets were sacrificed, and tissue samples of ileal Peyer’s patches were collected for the evaluation of IL1α, IL1β, IL6, IL10, TNFα, TLR2, TLR4 and PPARγ gene expression. Nucleotides supplementation significantly increased BW (17.37 vs. 19.00 kg/pig; p = <.01), ADG (.351 vs. .400 kg/d; p < .01), and FI (3.96 vs. 4.39 kg/d; p < .01), but not G:F (.61 vs. .64; p = .29). Faecal consistency was not different between the experimental groups and no occurrence of diarrhoea was reported. IgA and IgG content in blood was not influenced by the treatment, as well as gene expression of inflammatory cytokines in Peyer’s patches. The present trial shows that nucleotide administration is able to improve growth performance of post-weaning piglets, with no effects on inflammatory response and the expression of immune-related genes. Highlights Nucleotides administration increased BW, ADG and FI. Nucleotides did not affect inflammatory and immune response. |
| first_indexed | 2024-12-17T03:44:51Z |
| format | Article |
| id | doaj.art-e18a52111eb145769ca126eb37d978b4 |
| institution | Directory Open Access Journal |
| issn | 1594-4077 1828-051X |
| language | English |
| last_indexed | 2024-12-17T03:44:51Z |
| publishDate | 2020-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Italian Journal of Animal Science |
| spelling | doaj.art-e18a52111eb145769ca126eb37d978b42022-12-21T22:04:55ZengTaylor & Francis GroupItalian Journal of Animal Science1594-40771828-051X2020-12-0119129530110.1080/1828051X.2020.17389661738966Effects of nucleotides administration on growth performance and immune response of post-weaning pigletsVera Perricone0Marcello Comi1Valentino Bontempo2Cristina Lecchi3Fabrizio Ceciliani4Maurizio Crestani5Alessandra Ferrari6Giovanni Savoini7Alessandro Agazzi8Dipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare (VESPA), University of MilanDipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare (VESPA), University of MilanDipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare (VESPA), University of MilanDipartimento di Medicina Veterinaria (DIMEVET), University of MilanDipartimento di Medicina Veterinaria (DIMEVET), University of MilanDipartimento di Scienze Farmacologiche e Biomolecolari, University of MilanDipartimento di Scienze Farmacologiche e Biomolecolari, University of MilanDipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare (VESPA), University of MilanDipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare (VESPA), University of MilanThe aim of this study was to assess the effect of nucleotides administration on growth performance and immune response in post-weaning piglets. Twenty-eight male weaned piglets, homogeneous for age and weight were randomly allocated to two experimental treatments. Treated group (T) was daily orally administered 0.8 g/head of a mixture of nucleotides suspended in 2.1 mL water solution; while control group (C) received 2.1 mL saline solution. Body weight (BW) and average daily gain (ADG) were individually recorded weekly, while feed intake (FI), and gain:feed (G:F) were recorded and calculated on pen basis. Faecal score was evaluated every seven days. On day 0, 9, 18 and 27 blood samples were collected to determine IgA, IgG and haptoglobin concentration. At day 28 all piglets were sacrificed, and tissue samples of ileal Peyer’s patches were collected for the evaluation of IL1α, IL1β, IL6, IL10, TNFα, TLR2, TLR4 and PPARγ gene expression. Nucleotides supplementation significantly increased BW (17.37 vs. 19.00 kg/pig; p = <.01), ADG (.351 vs. .400 kg/d; p < .01), and FI (3.96 vs. 4.39 kg/d; p < .01), but not G:F (.61 vs. .64; p = .29). Faecal consistency was not different between the experimental groups and no occurrence of diarrhoea was reported. IgA and IgG content in blood was not influenced by the treatment, as well as gene expression of inflammatory cytokines in Peyer’s patches. The present trial shows that nucleotide administration is able to improve growth performance of post-weaning piglets, with no effects on inflammatory response and the expression of immune-related genes. Highlights Nucleotides administration increased BW, ADG and FI. Nucleotides did not affect inflammatory and immune response.http://dx.doi.org/10.1080/1828051X.2020.1738966nucleotidesweaninggrowth performanceimmune-related genespig |
| spellingShingle | Vera Perricone Marcello Comi Valentino Bontempo Cristina Lecchi Fabrizio Ceciliani Maurizio Crestani Alessandra Ferrari Giovanni Savoini Alessandro Agazzi Effects of nucleotides administration on growth performance and immune response of post-weaning piglets Italian Journal of Animal Science nucleotides weaning growth performance immune-related genes pig |
| title | Effects of nucleotides administration on growth performance and immune response of post-weaning piglets |
| title_full | Effects of nucleotides administration on growth performance and immune response of post-weaning piglets |
| title_fullStr | Effects of nucleotides administration on growth performance and immune response of post-weaning piglets |
| title_full_unstemmed | Effects of nucleotides administration on growth performance and immune response of post-weaning piglets |
| title_short | Effects of nucleotides administration on growth performance and immune response of post-weaning piglets |
| title_sort | effects of nucleotides administration on growth performance and immune response of post weaning piglets |
| topic | nucleotides weaning growth performance immune-related genes pig |
| url | http://dx.doi.org/10.1080/1828051X.2020.1738966 |
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