Evaluation of the effect of crocin on prevention of atrial fibrillation after coronary artery bypass grafting or heart valve replacement: A double-blind, randomized, placebo-controlled trial
Objective: The aim of this study was to evaluate the effect of crocin on the prevention of atrial fibrillation after coronary artery bypass grafting (CABG) and heart valve replacement.Materials and Methods: 100 patients who were scheduled for CABG or heart valve replacement surgeries were randomly a...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2022-11-01
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| Series: | Avicenna Journal of Phytomedicine |
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| Online Access: | https://ajp.mums.ac.ir/article_20908_afa0be2914f722628d40b25d72d428e0.pdf |
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| author | Seyyed Hamed Hashemi Shahri Ghasem Soltani Mohammad Abbasi Teshnizi Aliasghar Moeinipour Mohammad Tayyebi Reza Javidi Dasht Bayaz Farshad Abedi Vahid Ghavami Shahram Amini Amir Hooshang Mohammadpour |
| author_facet | Seyyed Hamed Hashemi Shahri Ghasem Soltani Mohammad Abbasi Teshnizi Aliasghar Moeinipour Mohammad Tayyebi Reza Javidi Dasht Bayaz Farshad Abedi Vahid Ghavami Shahram Amini Amir Hooshang Mohammadpour |
| author_sort | Seyyed Hamed Hashemi Shahri |
| collection | DOAJ |
| description | Objective: The aim of this study was to evaluate the effect of crocin on the prevention of atrial fibrillation after coronary artery bypass grafting (CABG) and heart valve replacement.Materials and Methods: 100 patients who were scheduled for CABG or heart valve replacement surgeries were randomly assigned into two groups of treatment and placebo. In the treatment group, patients received crocin tablets from three days prior to surgery and on the first three postoperative days (for a total of six days). During the first three days after surgery, postoperative atrial fibrillation (POAF) was assessed by electrocardiogram monitoring. Prooxidant–antioxidant balance (PAB) and c-reactive protein (CRP) levels were also assessed.Results: POAF developed in 7 patients in the treatment group versus 18 patients in the control (p=0.02). PAB levels were significantly lower in the crocin group (p<0.001), while differences in CRP levels were insignificant (p=0.39).Conclusion: It seems that prophylactic use of crocin is effective in reducing the incidence of POAF in patients undergoing heart surgeries. |
| first_indexed | 2024-04-11T08:23:58Z |
| format | Article |
| id | doaj.art-e18b98e910fa4d82a6574af5439f5060 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-04-11T08:23:58Z |
| publishDate | 2022-11-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-e18b98e910fa4d82a6574af5439f50602022-12-22T04:34:50ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492022-11-0112658960110.22038/ajp.2022.2090820908Evaluation of the effect of crocin on prevention of atrial fibrillation after coronary artery bypass grafting or heart valve replacement: A double-blind, randomized, placebo-controlled trialSeyyed Hamed Hashemi Shahri0Ghasem Soltani1Mohammad Abbasi Teshnizi2Aliasghar Moeinipour3Mohammad Tayyebi4Reza Javidi Dasht Bayaz5Farshad Abedi6Vahid Ghavami7Shahram Amini8Amir Hooshang Mohammadpour9Department of Clinical pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Anesthesia, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranCardiac Surgeon, Department of Cardiac Surgery, Mashhad University of Medical Sciences, Mashhad, IranCardiac Surgeon, Department of Cardiac Surgery, Mashhad University of Medical Sciences, Mashhad, IranVascular and Endovascular Surgery Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranCardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Clinical pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Biostatistics, Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Anesthesia, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Clinical pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranObjective: The aim of this study was to evaluate the effect of crocin on the prevention of atrial fibrillation after coronary artery bypass grafting (CABG) and heart valve replacement.Materials and Methods: 100 patients who were scheduled for CABG or heart valve replacement surgeries were randomly assigned into two groups of treatment and placebo. In the treatment group, patients received crocin tablets from three days prior to surgery and on the first three postoperative days (for a total of six days). During the first three days after surgery, postoperative atrial fibrillation (POAF) was assessed by electrocardiogram monitoring. Prooxidant–antioxidant balance (PAB) and c-reactive protein (CRP) levels were also assessed.Results: POAF developed in 7 patients in the treatment group versus 18 patients in the control (p=0.02). PAB levels were significantly lower in the crocin group (p<0.001), while differences in CRP levels were insignificant (p=0.39).Conclusion: It seems that prophylactic use of crocin is effective in reducing the incidence of POAF in patients undergoing heart surgeries.https://ajp.mums.ac.ir/article_20908_afa0be2914f722628d40b25d72d428e0.pdfatrial fibrillationcoronary artery bypass graftheart valve replacementcrocin |
| spellingShingle | Seyyed Hamed Hashemi Shahri Ghasem Soltani Mohammad Abbasi Teshnizi Aliasghar Moeinipour Mohammad Tayyebi Reza Javidi Dasht Bayaz Farshad Abedi Vahid Ghavami Shahram Amini Amir Hooshang Mohammadpour Evaluation of the effect of crocin on prevention of atrial fibrillation after coronary artery bypass grafting or heart valve replacement: A double-blind, randomized, placebo-controlled trial Avicenna Journal of Phytomedicine atrial fibrillation coronary artery bypass graft heart valve replacement crocin |
| title | Evaluation of the effect of crocin on prevention of atrial fibrillation after coronary artery bypass grafting or heart valve replacement: A double-blind, randomized, placebo-controlled trial |
| title_full | Evaluation of the effect of crocin on prevention of atrial fibrillation after coronary artery bypass grafting or heart valve replacement: A double-blind, randomized, placebo-controlled trial |
| title_fullStr | Evaluation of the effect of crocin on prevention of atrial fibrillation after coronary artery bypass grafting or heart valve replacement: A double-blind, randomized, placebo-controlled trial |
| title_full_unstemmed | Evaluation of the effect of crocin on prevention of atrial fibrillation after coronary artery bypass grafting or heart valve replacement: A double-blind, randomized, placebo-controlled trial |
| title_short | Evaluation of the effect of crocin on prevention of atrial fibrillation after coronary artery bypass grafting or heart valve replacement: A double-blind, randomized, placebo-controlled trial |
| title_sort | evaluation of the effect of crocin on prevention of atrial fibrillation after coronary artery bypass grafting or heart valve replacement a double blind randomized placebo controlled trial |
| topic | atrial fibrillation coronary artery bypass graft heart valve replacement crocin |
| url | https://ajp.mums.ac.ir/article_20908_afa0be2914f722628d40b25d72d428e0.pdf |
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