Ergosterol biosynthesis and drug development for Chagas disease

Ergosterol biosynthesis and drug development for Chagas disease

This article presents an overview of the currently available drugs nifurtimox (NFX) and benznidazole (BZN) used against Trypanosoma cruzi, the aetiological agent of Chagas disease; herein we discuss their limitations along with potential alternatives with a focus on ergosterol biosynthesis inhibitor...

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Bibliographic Details
Main Author:	Julio A Urbina
Format:	Article
Language:	English
Published:	Fundação Oswaldo Cruz (FIOCRUZ) 2009-07-01
Series:	Memorias do Instituto Oswaldo Cruz
Subjects:	chemotherapy Trypanosoma cruzi sterol biosynthesis sterol C14± demethylase squalene synthase oxidosqualene cyclise amiodarone
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900041

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