Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity
Background: Adipose tissue macrophages (ATMs) are a well characterized regulator of adipose tissue inflammatory tone. Previously defined by the M1 vs M2 classification, we now have a better understanding of ATM diversity that departs from the old paradigm and reports a spectrum of ATM function and p...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Molecular Metabolism |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212877822002113 |
| _version_ | 1811177648509943808 |
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| author | Sierra A. Nance Lindsey Muir Carey Lumeng |
| author_facet | Sierra A. Nance Lindsey Muir Carey Lumeng |
| author_sort | Sierra A. Nance |
| collection | DOAJ |
| description | Background: Adipose tissue macrophages (ATMs) are a well characterized regulator of adipose tissue inflammatory tone. Previously defined by the M1 vs M2 classification, we now have a better understanding of ATM diversity that departs from the old paradigm and reports a spectrum of ATM function and phenotypes in both brown and white adipose tissue. Scope of Review: This review provides an updated overview of ATM activation and function, ATM diversity in humans and rodents, and novel ATM functions that contribute to metabolic homeostasis and disease. Major Conclusions: While the paradigm that resident ATMs predominate in the lean state and obesity leads to the accumulation of lipid-associated and inflammatory ATMs still broadly remains rigorously supported, the details of this model continue to be refined and single cell data provide new insight into ATM subtypes and states. |
| first_indexed | 2024-04-11T06:05:47Z |
| format | Article |
| id | doaj.art-e19037ec043c4d0d966931c30d86960b |
| institution | Directory Open Access Journal |
| issn | 2212-8778 |
| language | English |
| last_indexed | 2024-04-11T06:05:47Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Metabolism |
| spelling | doaj.art-e19037ec043c4d0d966931c30d86960b2022-12-22T04:41:31ZengElsevierMolecular Metabolism2212-87782022-12-0166101642Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesitySierra A. Nance0Lindsey Muir1Carey Lumeng2Molecular & Integrative Physiology, University of Michigan Medical School, United States; Department of Pediatrics, University of Michigan Medical School, United StatesComputational Medicine and Bioinformatics, University of Michigan Medical School, United StatesMolecular & Integrative Physiology, University of Michigan Medical School, United States; Department of Pediatrics, University of Michigan Medical School, United States; Corresponding author. 109 Zina Pitcher Place, 2057 BSRB, Ann Arbor, MI 48109, United States.Background: Adipose tissue macrophages (ATMs) are a well characterized regulator of adipose tissue inflammatory tone. Previously defined by the M1 vs M2 classification, we now have a better understanding of ATM diversity that departs from the old paradigm and reports a spectrum of ATM function and phenotypes in both brown and white adipose tissue. Scope of Review: This review provides an updated overview of ATM activation and function, ATM diversity in humans and rodents, and novel ATM functions that contribute to metabolic homeostasis and disease. Major Conclusions: While the paradigm that resident ATMs predominate in the lean state and obesity leads to the accumulation of lipid-associated and inflammatory ATMs still broadly remains rigorously supported, the details of this model continue to be refined and single cell data provide new insight into ATM subtypes and states.http://www.sciencedirect.com/science/article/pii/S2212877822002113Adipose tissueMacrophageObesityInflammationLipids |
| spellingShingle | Sierra A. Nance Lindsey Muir Carey Lumeng Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity Molecular Metabolism Adipose tissue Macrophage Obesity Inflammation Lipids |
| title | Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity |
| title_full | Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity |
| title_fullStr | Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity |
| title_full_unstemmed | Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity |
| title_short | Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity |
| title_sort | adipose tissue macrophages regulators of adipose tissue immunometabolism during obesity |
| topic | Adipose tissue Macrophage Obesity Inflammation Lipids |
| url | http://www.sciencedirect.com/science/article/pii/S2212877822002113 |
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