Legg–Calvé–Perthes disease overview
Abstract Background Legg–Calvé–Perthes Disease (LCPD) is a necrosis of the femoral head which affects the range of motion of the hips. Its incidence is variable, ranging from 0.4/100,000 to 29.0/ 100,000 children. Although LCPD was first described in the beginning of the past century, limited is kno...
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | Orphanet Journal of Rare Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13023-022-02275-z |
| _version_ | 1818673436627566592 |
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| author | Armando O. Rodríguez-Olivas Edgar Hernández-Zamora Elba Reyes-Maldonado |
| author_facet | Armando O. Rodríguez-Olivas Edgar Hernández-Zamora Elba Reyes-Maldonado |
| author_sort | Armando O. Rodríguez-Olivas |
| collection | DOAJ |
| description | Abstract Background Legg–Calvé–Perthes Disease (LCPD) is a necrosis of the femoral head which affects the range of motion of the hips. Its incidence is variable, ranging from 0.4/100,000 to 29.0/ 100,000 children. Although LCPD was first described in the beginning of the past century, limited is known about its etiology. Our objective is to describe the main areas of interest in Legg–Calve–Perthes disease. Methods A review of the literature regarding LCPD etiology was performed, considering the following inclusion criteria: Studies reporting clinical or preclinical results. The research group carried out a filtered search on the PubMed and Science Direct databases. To maximize the suitability of the search results, we combined the terms ‘‘Perthes disease” OR “LCPD” OR “children avascular femoral head necrosis” with “diagnostic” OR “treatment” OR “etiology” as either key words or MeSH terms. Results In this article been described some areas of interest in LCPD, we include topics such as: history, incidence, pathogenesis, diagnosis, treatment and possible etiology, since LCPD has an unknown etiology. Conclusions This review suggests that LCPD has a multifactorial etiology where environmental, metabolic and genetic agents could be involved. |
| first_indexed | 2024-12-17T07:55:46Z |
| format | Article |
| id | doaj.art-e190e4e9190b48998ef09fbeb9efe82b |
| institution | Directory Open Access Journal |
| issn | 1750-1172 |
| language | English |
| last_indexed | 2024-12-17T07:55:46Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Orphanet Journal of Rare Diseases |
| spelling | doaj.art-e190e4e9190b48998ef09fbeb9efe82b2022-12-21T21:57:42ZengBMCOrphanet Journal of Rare Diseases1750-11722022-03-0117111110.1186/s13023-022-02275-zLegg–Calvé–Perthes disease overviewArmando O. Rodríguez-Olivas0Edgar Hernández-Zamora1Elba Reyes-Maldonado2Department of Morphology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico NacionalDepartment of Morphology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico NacionalDepartment of Morphology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico NacionalAbstract Background Legg–Calvé–Perthes Disease (LCPD) is a necrosis of the femoral head which affects the range of motion of the hips. Its incidence is variable, ranging from 0.4/100,000 to 29.0/ 100,000 children. Although LCPD was first described in the beginning of the past century, limited is known about its etiology. Our objective is to describe the main areas of interest in Legg–Calve–Perthes disease. Methods A review of the literature regarding LCPD etiology was performed, considering the following inclusion criteria: Studies reporting clinical or preclinical results. The research group carried out a filtered search on the PubMed and Science Direct databases. To maximize the suitability of the search results, we combined the terms ‘‘Perthes disease” OR “LCPD” OR “children avascular femoral head necrosis” with “diagnostic” OR “treatment” OR “etiology” as either key words or MeSH terms. Results In this article been described some areas of interest in LCPD, we include topics such as: history, incidence, pathogenesis, diagnosis, treatment and possible etiology, since LCPD has an unknown etiology. Conclusions This review suggests that LCPD has a multifactorial etiology where environmental, metabolic and genetic agents could be involved.https://doi.org/10.1186/s13023-022-02275-zLCPDDiagnosisTreatmentEnvironmental factorsBiochemical factorsGenetic factors |
| spellingShingle | Armando O. Rodríguez-Olivas Edgar Hernández-Zamora Elba Reyes-Maldonado Legg–Calvé–Perthes disease overview Orphanet Journal of Rare Diseases LCPD Diagnosis Treatment Environmental factors Biochemical factors Genetic factors |
| title | Legg–Calvé–Perthes disease overview |
| title_full | Legg–Calvé–Perthes disease overview |
| title_fullStr | Legg–Calvé–Perthes disease overview |
| title_full_unstemmed | Legg–Calvé–Perthes disease overview |
| title_short | Legg–Calvé–Perthes disease overview |
| title_sort | legg calve perthes disease overview |
| topic | LCPD Diagnosis Treatment Environmental factors Biochemical factors Genetic factors |
| url | https://doi.org/10.1186/s13023-022-02275-z |
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