Associations of <i>MC4R</i>, <i>LEP,</i> and <i>LEPR</i> Polymorphisms with Obesity-Related Parameters in Childhood and Adulthood
<i>MC4R</i>, <i>LEP</i>, and <i>LEPR</i> genes are involved in the hypothalamic leptin-melanocortin regulation pathway, which is important for energy homeostasis. Our study aimed to evaluate the associations between the <i>MC4R</i> rs17782313, <i>...
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MDPI AG
2021-06-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/6/949 |
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| author | Asta Raskiliene Alina Smalinskiene Vilma Kriaucioniene Vaiva Lesauskaite Janina Petkeviciene |
| author_facet | Asta Raskiliene Alina Smalinskiene Vilma Kriaucioniene Vaiva Lesauskaite Janina Petkeviciene |
| author_sort | Asta Raskiliene |
| collection | DOAJ |
| description | <i>MC4R</i>, <i>LEP</i>, and <i>LEPR</i> genes are involved in the hypothalamic leptin-melanocortin regulation pathway, which is important for energy homeostasis. Our study aimed to evaluate the associations between the <i>MC4R</i> rs17782313, <i>LEP</i> rs7799039, and <i>LEPR</i> rs1137101 polymorphisms with obesity-related parameters in childhood and adulthood. The data were obtained from the Kaunas Cardiovascular Risk Cohort study, which started in 1977 with 1082 participants aged 12–13 years. In 2012–2014, the follow-up survey was carried out. Genotype analysis of all respondents (<i>n</i> = 509) aged 48–49 years was performed for the gene polymorphisms using Real-Time Polymerase Chain Reaction. Anthropometric measurements were performed in childhood and adulthood. In childhood, only skinfold thicknesses were associated with gene variants being the lowest in children with <i>MC4R</i> TT genotype and <i>LEP</i> AG genotype. In adulthood, odds of obesity and metabolic syndrome was higher in <i>MC4R</i> CT/CC genotype than TT genotype carriers (OR 1.8; 95% CI 1.2–2.8 and OR 1.6; 95% CI 1.1–2.4, respectively). In men, physical activity attenuated the effect of the <i>MC4R</i> rs17782313 on obesity. The <i>LEP</i> GG genotype was associated with higher BMI, waist circumference, and visceral fat level only in men. No associations of the <i>LEPR</i> rs1137101 polymorphisms with anthropometric measurements and leptin level were found. In conclusion, the associations of the <i>MC4R</i> and <i>LEP</i> gene polymorphisms with obesity-related parameters strengthened with age. |
| first_indexed | 2024-03-10T10:13:07Z |
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| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T10:13:07Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-e19272d90d80494fab78842c51995eef2023-11-22T01:03:36ZengMDPI AGGenes2073-44252021-06-0112694910.3390/genes12060949Associations of <i>MC4R</i>, <i>LEP,</i> and <i>LEPR</i> Polymorphisms with Obesity-Related Parameters in Childhood and AdulthoodAsta Raskiliene0Alina Smalinskiene1Vilma Kriaucioniene2Vaiva Lesauskaite3Janina Petkeviciene4Health Research Institute, Faculty of Public Health, Lithuanian University of Health Sciences, 44307 Kaunas, LithuaniaLaboratory of Molecular Cardiology, Institute of Cardiology, Lithuanian University of Health Sciences, 50103 Kaunas, LithuaniaHealth Research Institute, Faculty of Public Health, Lithuanian University of Health Sciences, 44307 Kaunas, LithuaniaLaboratory of Molecular Cardiology, Institute of Cardiology, Lithuanian University of Health Sciences, 50103 Kaunas, LithuaniaHealth Research Institute, Faculty of Public Health, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania<i>MC4R</i>, <i>LEP</i>, and <i>LEPR</i> genes are involved in the hypothalamic leptin-melanocortin regulation pathway, which is important for energy homeostasis. Our study aimed to evaluate the associations between the <i>MC4R</i> rs17782313, <i>LEP</i> rs7799039, and <i>LEPR</i> rs1137101 polymorphisms with obesity-related parameters in childhood and adulthood. The data were obtained from the Kaunas Cardiovascular Risk Cohort study, which started in 1977 with 1082 participants aged 12–13 years. In 2012–2014, the follow-up survey was carried out. Genotype analysis of all respondents (<i>n</i> = 509) aged 48–49 years was performed for the gene polymorphisms using Real-Time Polymerase Chain Reaction. Anthropometric measurements were performed in childhood and adulthood. In childhood, only skinfold thicknesses were associated with gene variants being the lowest in children with <i>MC4R</i> TT genotype and <i>LEP</i> AG genotype. In adulthood, odds of obesity and metabolic syndrome was higher in <i>MC4R</i> CT/CC genotype than TT genotype carriers (OR 1.8; 95% CI 1.2–2.8 and OR 1.6; 95% CI 1.1–2.4, respectively). In men, physical activity attenuated the effect of the <i>MC4R</i> rs17782313 on obesity. The <i>LEP</i> GG genotype was associated with higher BMI, waist circumference, and visceral fat level only in men. No associations of the <i>LEPR</i> rs1137101 polymorphisms with anthropometric measurements and leptin level were found. In conclusion, the associations of the <i>MC4R</i> and <i>LEP</i> gene polymorphisms with obesity-related parameters strengthened with age.https://www.mdpi.com/2073-4425/12/6/949anthropometric measurementssingle-nucleotide polymorphismleptin-melanocortin regulation pathwayphysical activitychildhoodadulthood |
| spellingShingle | Asta Raskiliene Alina Smalinskiene Vilma Kriaucioniene Vaiva Lesauskaite Janina Petkeviciene Associations of <i>MC4R</i>, <i>LEP,</i> and <i>LEPR</i> Polymorphisms with Obesity-Related Parameters in Childhood and Adulthood Genes anthropometric measurements single-nucleotide polymorphism leptin-melanocortin regulation pathway physical activity childhood adulthood |
| title | Associations of <i>MC4R</i>, <i>LEP,</i> and <i>LEPR</i> Polymorphisms with Obesity-Related Parameters in Childhood and Adulthood |
| title_full | Associations of <i>MC4R</i>, <i>LEP,</i> and <i>LEPR</i> Polymorphisms with Obesity-Related Parameters in Childhood and Adulthood |
| title_fullStr | Associations of <i>MC4R</i>, <i>LEP,</i> and <i>LEPR</i> Polymorphisms with Obesity-Related Parameters in Childhood and Adulthood |
| title_full_unstemmed | Associations of <i>MC4R</i>, <i>LEP,</i> and <i>LEPR</i> Polymorphisms with Obesity-Related Parameters in Childhood and Adulthood |
| title_short | Associations of <i>MC4R</i>, <i>LEP,</i> and <i>LEPR</i> Polymorphisms with Obesity-Related Parameters in Childhood and Adulthood |
| title_sort | associations of i mc4r i i lep i and i lepr i polymorphisms with obesity related parameters in childhood and adulthood |
| topic | anthropometric measurements single-nucleotide polymorphism leptin-melanocortin regulation pathway physical activity childhood adulthood |
| url | https://www.mdpi.com/2073-4425/12/6/949 |
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