Platelet count and Interleukin 6 Gene polymorphism in healthy subjects
<p>Abstract</p> <p>Background</p> <p>Interleukin 6 (IL-6) is thought to play important roles in the development of reactive thrombocytosis caused by inflammation by its stimulatory effect on megakaryocytopoiesis. A G/C polymorphism of the IL-6 gene at position -174 has...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2001-06-01
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| Series: | BMC Medical Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2350/2/6 |
| _version_ | 1818909481174564864 |
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| author | Gutierrez Cristina Richart Cristobal Vendrell Joan Fernandez-Real José-Manuel Ricart Wifredo |
| author_facet | Gutierrez Cristina Richart Cristobal Vendrell Joan Fernandez-Real José-Manuel Ricart Wifredo |
| author_sort | Gutierrez Cristina |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Interleukin 6 (IL-6) is thought to play important roles in the development of reactive thrombocytosis caused by inflammation by its stimulatory effect on megakaryocytopoiesis. A G/C polymorphism of the IL-6 gene at position -174 has been found to be associated to different transcription rates. Specifically, subjects with the CC genotype showed lower plasma IL-6 levels compared with GC or GG subjects. Given this difference in transcription rates of IL-6 we speculated on different platelet count according to this IL-6 polymorphism.</p> <p>Methods</p> <p>The G/C polymorphism of the <it>IL-6</it> gene at position -174, serum IL-6 concentration and platelet count were prospectively analyzed in 59 (25 women) consecutive healthy subjects.</p> <p>Results</p> <p>Subjects who were homozygotes for the C allele at position -174 of the <it>IL-6</it> gene (Sfa NI genotype) showed significantly lower platelet count than carriers of the G allele, despite similar age, sex, body mass index and proportion of smokers (205400 ± 44088 vs 239818 ± 60194, p = 0.047). This was in parallel to differences in peripheral white blood cell count (5807 ± 1671 vs 6867 ± 1192 × 10<sup>9</sup>/ml, p = 0.01).</p> <p>Conclusion</p> <p>This is the first description, to our knowledge, of a genetical influence on basal platelet counts, which appears to be partially dependent on a polymorphism of the <it>IL-6</it> gene, even in the absence of inflammation.</p> |
| first_indexed | 2024-12-19T22:27:36Z |
| format | Article |
| id | doaj.art-e1967d36d3a84d6f99947411535e196a |
| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-12-19T22:27:36Z |
| publishDate | 2001-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genetics |
| spelling | doaj.art-e1967d36d3a84d6f99947411535e196a2022-12-21T20:03:27ZengBMCBMC Medical Genetics1471-23502001-06-0121610.1186/1471-2350-2-6Platelet count and Interleukin 6 Gene polymorphism in healthy subjectsGutierrez CristinaRichart CristobalVendrell JoanFernandez-Real José-ManuelRicart Wifredo<p>Abstract</p> <p>Background</p> <p>Interleukin 6 (IL-6) is thought to play important roles in the development of reactive thrombocytosis caused by inflammation by its stimulatory effect on megakaryocytopoiesis. A G/C polymorphism of the IL-6 gene at position -174 has been found to be associated to different transcription rates. Specifically, subjects with the CC genotype showed lower plasma IL-6 levels compared with GC or GG subjects. Given this difference in transcription rates of IL-6 we speculated on different platelet count according to this IL-6 polymorphism.</p> <p>Methods</p> <p>The G/C polymorphism of the <it>IL-6</it> gene at position -174, serum IL-6 concentration and platelet count were prospectively analyzed in 59 (25 women) consecutive healthy subjects.</p> <p>Results</p> <p>Subjects who were homozygotes for the C allele at position -174 of the <it>IL-6</it> gene (Sfa NI genotype) showed significantly lower platelet count than carriers of the G allele, despite similar age, sex, body mass index and proportion of smokers (205400 ± 44088 vs 239818 ± 60194, p = 0.047). This was in parallel to differences in peripheral white blood cell count (5807 ± 1671 vs 6867 ± 1192 × 10<sup>9</sup>/ml, p = 0.01).</p> <p>Conclusion</p> <p>This is the first description, to our knowledge, of a genetical influence on basal platelet counts, which appears to be partially dependent on a polymorphism of the <it>IL-6</it> gene, even in the absence of inflammation.</p>http://www.biomedcentral.com/1471-2350/2/6 |
| spellingShingle | Gutierrez Cristina Richart Cristobal Vendrell Joan Fernandez-Real José-Manuel Ricart Wifredo Platelet count and Interleukin 6 Gene polymorphism in healthy subjects BMC Medical Genetics |
| title | Platelet count and Interleukin 6 Gene polymorphism in healthy subjects |
| title_full | Platelet count and Interleukin 6 Gene polymorphism in healthy subjects |
| title_fullStr | Platelet count and Interleukin 6 Gene polymorphism in healthy subjects |
| title_full_unstemmed | Platelet count and Interleukin 6 Gene polymorphism in healthy subjects |
| title_short | Platelet count and Interleukin 6 Gene polymorphism in healthy subjects |
| title_sort | platelet count and interleukin 6 gene polymorphism in healthy subjects |
| url | http://www.biomedcentral.com/1471-2350/2/6 |
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