Retinoid nanoparticulates: Approachable gateway for acne treatment
Acne vulgaris is a skin disorder that results due to clogging of hair follicles with dead skin cells and oils from the skin. Although acne is not a fatal disease, it has serious effects on the patients' physical and emotional states due to the fear of permanent scars, reduced self-confidence, d...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Health Sciences Review |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772632022000319 |
| _version_ | 1818049530975748096 |
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| author | Judy Lalrengpuii Kaisar Raza Awanish Mishra Rahul Shukla |
| author_facet | Judy Lalrengpuii Kaisar Raza Awanish Mishra Rahul Shukla |
| author_sort | Judy Lalrengpuii |
| collection | DOAJ |
| description | Acne vulgaris is a skin disorder that results due to clogging of hair follicles with dead skin cells and oils from the skin. Although acne is not a fatal disease, it has serious effects on the patients' physical and emotional states due to the fear of permanent scars, reduced self-confidence, depression and avoidance of social interactions, and even the tendency to commit suicide. Topical retinoids are the first-line treatment for most forms of Acne vulgaris. Poor aqueous solubility coupled with physical or chemical instability limits the applications of retinoids for anti-acne therapy. Nanoformulations of retinoids can overcome many problems associated with conventional retinoid formulations by improving the solubility, stability, reducing skin irritation, improving the drug targeting and enhancing the therapeutic efficacy. This review details on formulation, characterization and in vivo/in vitro evaluation of selected nanoparticles loaded with retinoids and envisions articulating the findings from the literature into potential promises. |
| first_indexed | 2024-12-10T10:39:03Z |
| format | Article |
| id | doaj.art-e1968cf525764aa78b7c3923c7e211f9 |
| institution | Directory Open Access Journal |
| issn | 2772-6320 |
| language | English |
| last_indexed | 2024-12-10T10:39:03Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Health Sciences Review |
| spelling | doaj.art-e1968cf525764aa78b7c3923c7e211f92022-12-22T01:52:22ZengElsevierHealth Sciences Review2772-63202022-09-014100042Retinoid nanoparticulates: Approachable gateway for acne treatmentJudy Lalrengpuii0Kaisar Raza1Awanish Mishra2Rahul Shukla3Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research-Raebareli, Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow, Uttar Pradesh 226002, IndiaDepartment of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Dist. Ajmer, Rajasthan 305817, IndiaDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Changsari, Guwahati, Assam 781101, IndiaDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research-Raebareli, Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow, Uttar Pradesh 226002, India; Corresponding author.Acne vulgaris is a skin disorder that results due to clogging of hair follicles with dead skin cells and oils from the skin. Although acne is not a fatal disease, it has serious effects on the patients' physical and emotional states due to the fear of permanent scars, reduced self-confidence, depression and avoidance of social interactions, and even the tendency to commit suicide. Topical retinoids are the first-line treatment for most forms of Acne vulgaris. Poor aqueous solubility coupled with physical or chemical instability limits the applications of retinoids for anti-acne therapy. Nanoformulations of retinoids can overcome many problems associated with conventional retinoid formulations by improving the solubility, stability, reducing skin irritation, improving the drug targeting and enhancing the therapeutic efficacy. This review details on formulation, characterization and in vivo/in vitro evaluation of selected nanoparticles loaded with retinoids and envisions articulating the findings from the literature into potential promises.http://www.sciencedirect.com/science/article/pii/S2772632022000319RetinoidsNanomedicineAcneTopicalGel |
| spellingShingle | Judy Lalrengpuii Kaisar Raza Awanish Mishra Rahul Shukla Retinoid nanoparticulates: Approachable gateway for acne treatment Health Sciences Review Retinoids Nanomedicine Acne Topical Gel |
| title | Retinoid nanoparticulates: Approachable gateway for acne treatment |
| title_full | Retinoid nanoparticulates: Approachable gateway for acne treatment |
| title_fullStr | Retinoid nanoparticulates: Approachable gateway for acne treatment |
| title_full_unstemmed | Retinoid nanoparticulates: Approachable gateway for acne treatment |
| title_short | Retinoid nanoparticulates: Approachable gateway for acne treatment |
| title_sort | retinoid nanoparticulates approachable gateway for acne treatment |
| topic | Retinoids Nanomedicine Acne Topical Gel |
| url | http://www.sciencedirect.com/science/article/pii/S2772632022000319 |
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