Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance
Abstract The production and release of tumor-derived small extracellular vesicles (TDSEVs) from cancerous cells play a pivotal role in the propagation of cancer, through genetic and biological communication with healthy cells. TDSEVs are known to orchestrate the invasion-metastasis cascade via diver...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-024-01932-0 |
| _version_ | 1797350095013806080 |
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| author | Chi Zhang Chaoying Qin Saikat Dewanjee Hiranmoy Bhattacharya Pratik Chakraborty Niraj Kumar Jha Moumita Gangopadhyay Saurabh Kumar Jha Qing Liu |
| author_facet | Chi Zhang Chaoying Qin Saikat Dewanjee Hiranmoy Bhattacharya Pratik Chakraborty Niraj Kumar Jha Moumita Gangopadhyay Saurabh Kumar Jha Qing Liu |
| author_sort | Chi Zhang |
| collection | DOAJ |
| description | Abstract The production and release of tumor-derived small extracellular vesicles (TDSEVs) from cancerous cells play a pivotal role in the propagation of cancer, through genetic and biological communication with healthy cells. TDSEVs are known to orchestrate the invasion-metastasis cascade via diverse pathways. Regulation of early metastasis processes, pre-metastatic niche formation, immune system regulation, angiogenesis initiation, extracellular matrix (ECM) remodeling, immune modulation, and epithelial-mesenchymal transition (EMT) are among the pathways regulated by TDSEVs. MicroRNAs (miRs) carried within TDSEVs play a pivotal role as a double-edged sword and can either promote metastasis or inhibit cancer progression. TDSEVs can serve as excellent markers for early detection of tumors, and tumor metastases. From a therapeutic point of view, the risk of cancer metastasis may be reduced by limiting the production of TDSEVs from tumor cells. On the other hand, TDSEVs represent a promising approach for in vivo delivery of therapeutic cargo to tumor cells. The present review article discusses the recent developments and the current views of TDSEVs in the field of cancer research and clinical applications. |
| first_indexed | 2024-03-08T12:39:52Z |
| format | Article |
| id | doaj.art-e197dada377045cabf9ccc0d551f8b75 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-03-08T12:39:52Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-e197dada377045cabf9ccc0d551f8b752024-01-21T12:13:00ZengBMCMolecular Cancer1476-45982024-01-0123113010.1186/s12943-024-01932-0Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significanceChi Zhang0Chaoying Qin1Saikat Dewanjee2Hiranmoy Bhattacharya3Pratik Chakraborty4Niraj Kumar Jha5Moumita Gangopadhyay6Saurabh Kumar Jha7Qing Liu8Department of Neurosurgery, Xiangya Hospital, Central South UniversityDepartment of Neurosurgery, Xiangya Hospital, Central South UniversityAdvanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur UniversityAdvanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur UniversityAdvanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur UniversityCentre of Research Impact and Outreach, Chitkara University Institute of Engineering and Technology, Chitkara UniversityDepartment of Biotechnology, School of Life Science and Biotechnology, Adamas UniversityDepartment of Zoology, Kalindi College, University of DelhiDepartment of Neurosurgery, Xiangya Hospital, Central South UniversityAbstract The production and release of tumor-derived small extracellular vesicles (TDSEVs) from cancerous cells play a pivotal role in the propagation of cancer, through genetic and biological communication with healthy cells. TDSEVs are known to orchestrate the invasion-metastasis cascade via diverse pathways. Regulation of early metastasis processes, pre-metastatic niche formation, immune system regulation, angiogenesis initiation, extracellular matrix (ECM) remodeling, immune modulation, and epithelial-mesenchymal transition (EMT) are among the pathways regulated by TDSEVs. MicroRNAs (miRs) carried within TDSEVs play a pivotal role as a double-edged sword and can either promote metastasis or inhibit cancer progression. TDSEVs can serve as excellent markers for early detection of tumors, and tumor metastases. From a therapeutic point of view, the risk of cancer metastasis may be reduced by limiting the production of TDSEVs from tumor cells. On the other hand, TDSEVs represent a promising approach for in vivo delivery of therapeutic cargo to tumor cells. The present review article discusses the recent developments and the current views of TDSEVs in the field of cancer research and clinical applications.https://doi.org/10.1186/s12943-024-01932-0BiomarkersCancerEpithelial-mesenchymal transitionMetastasisMicroRNAOncogenic transformation |
| spellingShingle | Chi Zhang Chaoying Qin Saikat Dewanjee Hiranmoy Bhattacharya Pratik Chakraborty Niraj Kumar Jha Moumita Gangopadhyay Saurabh Kumar Jha Qing Liu Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance Molecular Cancer Biomarkers Cancer Epithelial-mesenchymal transition Metastasis MicroRNA Oncogenic transformation |
| title | Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance |
| title_full | Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance |
| title_fullStr | Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance |
| title_full_unstemmed | Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance |
| title_short | Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance |
| title_sort | tumor derived small extracellular vesicles in cancer invasion and metastasis molecular mechanisms and clinical significance |
| topic | Biomarkers Cancer Epithelial-mesenchymal transition Metastasis MicroRNA Oncogenic transformation |
| url | https://doi.org/10.1186/s12943-024-01932-0 |
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