Gold Nanoparticles as a Biosensor for Cancer Biomarker Determination

Molecular biology applications based on gold nanotechnology have revolutionary impacts, especially in diagnosing and treating molecular and cellular levels. The combination of plasmonic resonance, biochemistry, and optoelectronic engineering has increased the detection of molecules and the possibili...

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Main Authors: Chien-Hsiu Li, Ming-Hsien Chan, Yu-Chan Chang, Michael Hsiao
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/28/1/364
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author Chien-Hsiu Li
Ming-Hsien Chan
Yu-Chan Chang
Michael Hsiao
author_facet Chien-Hsiu Li
Ming-Hsien Chan
Yu-Chan Chang
Michael Hsiao
author_sort Chien-Hsiu Li
collection DOAJ
description Molecular biology applications based on gold nanotechnology have revolutionary impacts, especially in diagnosing and treating molecular and cellular levels. The combination of plasmonic resonance, biochemistry, and optoelectronic engineering has increased the detection of molecules and the possibility of atoms. These advantages have brought medical research to the cellular level for application potential. Many research groups are working towards this. The superior analytical properties of gold nanoparticles can not only be used as an effective drug screening instrument for gene sequencing in new drug development but also as an essential tool for detecting physiological functions, such as blood glucose, antigen-antibody analysis, etc. The review introduces the principles of biomedical sensing systems, the principles of nanomaterial analysis applied to biomedicine at home and abroad, and the chemical surface modification of various gold nanoparticles.
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spelling doaj.art-e198f164cb9449339189f5845eb6601e2023-12-02T00:42:36ZengMDPI AGMolecules1420-30492023-01-0128136410.3390/molecules28010364Gold Nanoparticles as a Biosensor for Cancer Biomarker DeterminationChien-Hsiu Li0Ming-Hsien Chan1Yu-Chan Chang2Michael Hsiao3Genomics Research Center, Academia Sinica, Taipei 115, TaiwanGenomics Research Center, Academia Sinica, Taipei 115, TaiwanDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 112, TaiwanGenomics Research Center, Academia Sinica, Taipei 115, TaiwanMolecular biology applications based on gold nanotechnology have revolutionary impacts, especially in diagnosing and treating molecular and cellular levels. The combination of plasmonic resonance, biochemistry, and optoelectronic engineering has increased the detection of molecules and the possibility of atoms. These advantages have brought medical research to the cellular level for application potential. Many research groups are working towards this. The superior analytical properties of gold nanoparticles can not only be used as an effective drug screening instrument for gene sequencing in new drug development but also as an essential tool for detecting physiological functions, such as blood glucose, antigen-antibody analysis, etc. The review introduces the principles of biomedical sensing systems, the principles of nanomaterial analysis applied to biomedicine at home and abroad, and the chemical surface modification of various gold nanoparticles.https://www.mdpi.com/1420-3049/28/1/364gold nanoparticlesbiosensingsurface plasmon resonancecancer markersurface modification
spellingShingle Chien-Hsiu Li
Ming-Hsien Chan
Yu-Chan Chang
Michael Hsiao
Gold Nanoparticles as a Biosensor for Cancer Biomarker Determination
Molecules
gold nanoparticles
biosensing
surface plasmon resonance
cancer marker
surface modification
title Gold Nanoparticles as a Biosensor for Cancer Biomarker Determination
title_full Gold Nanoparticles as a Biosensor for Cancer Biomarker Determination
title_fullStr Gold Nanoparticles as a Biosensor for Cancer Biomarker Determination
title_full_unstemmed Gold Nanoparticles as a Biosensor for Cancer Biomarker Determination
title_short Gold Nanoparticles as a Biosensor for Cancer Biomarker Determination
title_sort gold nanoparticles as a biosensor for cancer biomarker determination
topic gold nanoparticles
biosensing
surface plasmon resonance
cancer marker
surface modification
url https://www.mdpi.com/1420-3049/28/1/364
work_keys_str_mv AT chienhsiuli goldnanoparticlesasabiosensorforcancerbiomarkerdetermination
AT minghsienchan goldnanoparticlesasabiosensorforcancerbiomarkerdetermination
AT yuchanchang goldnanoparticlesasabiosensorforcancerbiomarkerdetermination
AT michaelhsiao goldnanoparticlesasabiosensorforcancerbiomarkerdetermination