The Multifunctionally Graded System for a Controlled Size Effect on Iron Oxide–Gold Based Core-Shell Nanoparticles
We report that Fe<sub>3</sub>O<sub>4</sub>@Au core-shell nanoparticles (NPs) serve as a multifunctional molecule delivery platform. This platform is also suitable for sensing the doxorubicin (DOX) through DNA hybridization, and the amount of carried DOX molecules was determin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/7/1695 |
| _version_ | 1827601097083060224 |
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| author | Bo-Wei Du Chih-Yuan Chu Ching-Chang Lin Fu-Hsiang Ko |
| author_facet | Bo-Wei Du Chih-Yuan Chu Ching-Chang Lin Fu-Hsiang Ko |
| author_sort | Bo-Wei Du |
| collection | DOAJ |
| description | We report that Fe<sub>3</sub>O<sub>4</sub>@Au core-shell nanoparticles (NPs) serve as a multifunctional molecule delivery platform. This platform is also suitable for sensing the doxorubicin (DOX) through DNA hybridization, and the amount of carried DOX molecules was determined by size-dependent Fe<sub>3</sub>O<sub>4</sub>@Au NPs. The limits of detection (LODs) for DOX was found to be 1.839 nM. In our approach, an Au nano-shell coating was coupled with a specially designed DNA sequence using thiol bonding. By means of a high-frequency magnetic field (HFMF), a high release percentage of such a molecule could be efficiently achieved in a relatively short period of time. Furthermore, the thickness increase of the Au nano-shell affords Fe<sub>3</sub>O<sub>4</sub>@Au NPs with a larger surface area and a smaller temperature increment due to shielding effects from magnetic field. The change of magnetic property may enable the developed Fe<sub>3</sub>O<sub>4</sub>@Au-dsDNA/DOX NPs to be used as future nanocarrier material. More importantly, the core-shell NP structures were demonstrated to act as a controllable and efficient factor for molecule delivery. |
| first_indexed | 2024-03-09T04:48:21Z |
| format | Article |
| id | doaj.art-e199875eab064ec29b746becd8296d9a |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T04:48:21Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-e199875eab064ec29b746becd8296d9a2023-12-03T13:13:30ZengMDPI AGNanomaterials2079-49912021-06-01117169510.3390/nano11071695The Multifunctionally Graded System for a Controlled Size Effect on Iron Oxide–Gold Based Core-Shell NanoparticlesBo-Wei Du0Chih-Yuan Chu1Ching-Chang Lin2Fu-Hsiang Ko3Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu 30010, TaiwanDepartment of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu 30010, TaiwanResearch Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, JapanDepartment of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu 30010, TaiwanWe report that Fe<sub>3</sub>O<sub>4</sub>@Au core-shell nanoparticles (NPs) serve as a multifunctional molecule delivery platform. This platform is also suitable for sensing the doxorubicin (DOX) through DNA hybridization, and the amount of carried DOX molecules was determined by size-dependent Fe<sub>3</sub>O<sub>4</sub>@Au NPs. The limits of detection (LODs) for DOX was found to be 1.839 nM. In our approach, an Au nano-shell coating was coupled with a specially designed DNA sequence using thiol bonding. By means of a high-frequency magnetic field (HFMF), a high release percentage of such a molecule could be efficiently achieved in a relatively short period of time. Furthermore, the thickness increase of the Au nano-shell affords Fe<sub>3</sub>O<sub>4</sub>@Au NPs with a larger surface area and a smaller temperature increment due to shielding effects from magnetic field. The change of magnetic property may enable the developed Fe<sub>3</sub>O<sub>4</sub>@Au-dsDNA/DOX NPs to be used as future nanocarrier material. More importantly, the core-shell NP structures were demonstrated to act as a controllable and efficient factor for molecule delivery.https://www.mdpi.com/2079-4991/11/7/1695molecular carriersmagnetic nanoparticlescore-shell nanostructureaptamersize effect |
| spellingShingle | Bo-Wei Du Chih-Yuan Chu Ching-Chang Lin Fu-Hsiang Ko The Multifunctionally Graded System for a Controlled Size Effect on Iron Oxide–Gold Based Core-Shell Nanoparticles Nanomaterials molecular carriers magnetic nanoparticles core-shell nanostructure aptamer size effect |
| title | The Multifunctionally Graded System for a Controlled Size Effect on Iron Oxide–Gold Based Core-Shell Nanoparticles |
| title_full | The Multifunctionally Graded System for a Controlled Size Effect on Iron Oxide–Gold Based Core-Shell Nanoparticles |
| title_fullStr | The Multifunctionally Graded System for a Controlled Size Effect on Iron Oxide–Gold Based Core-Shell Nanoparticles |
| title_full_unstemmed | The Multifunctionally Graded System for a Controlled Size Effect on Iron Oxide–Gold Based Core-Shell Nanoparticles |
| title_short | The Multifunctionally Graded System for a Controlled Size Effect on Iron Oxide–Gold Based Core-Shell Nanoparticles |
| title_sort | multifunctionally graded system for a controlled size effect on iron oxide gold based core shell nanoparticles |
| topic | molecular carriers magnetic nanoparticles core-shell nanostructure aptamer size effect |
| url | https://www.mdpi.com/2079-4991/11/7/1695 |
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