Malignant pleural mesothelioma: Clinicopathologic and survival characteristic in a consecutive series of 40 patients
"n Normal 0 false false false EN-GB X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:y...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Tehran University of Medical Sciences
2009-05-01
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| Series: | Tehran University Medical Journal |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/13598.pdf&manuscript_id=13598 |
| _version_ | 1818692550752468992 |
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| author | Bagheri R Haghy SZ Rahim MB Attaran D Silanian Toosi M |
| author_facet | Bagheri R Haghy SZ Rahim MB Attaran D Silanian Toosi M |
| author_sort | Bagheri R |
| collection | DOAJ |
| description | "n Normal 0 false false false EN-GB X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Pleural malignant mesothelioma is an uncommon but extremely invasive tumor which originates from mesothelial cells and usually occures after prolonged exposure to asbestos. The aim of this study was to clinicopathologically evaluation of 40 patients with pleural malignant mesothelioma and the main factors influencing their prognosis. "n"n Methods: In this study patients with definitive diagnosis, who had been followed up for at least three years were studied based on gender, age presenting symptoms, and clinicopathological patterns."n"n Results: Male to female ratio of the study patients was three to one any the average age of them was 55 years. Chest pain was the most common symptoms in 34(85%) patients. Most of the study patients were in Buchard stage I (37/5%) and the epithelial form was the most common pathological pattern 25(62.5%). 19(47.5%) of cases received only radiotherapy and chemotherapy. Extrapleural pneumonectomy was performed on eight (20%) patients, seven (17.5%) patients underwent decortication and pleurectomy beside adjuvant therapy and 15% of the cases rejected any type of treatment. Surgical mortality occurred in one patient and the most common surgical complication was wound infection. The average survival rate was 12±1.2 months and the main factors influencing it were the patient's physiologic status, pathological form, stage of the disease and the pattern of pleural involvement. "n"n Conclusions: Because the low survival rate after multimodality invasive treatments in mesothelioma, aggressive therapeutic methods were recommended in selected patients |
| first_indexed | 2024-12-17T12:59:35Z |
| format | Article |
| id | doaj.art-e19991c4077b4960b58c7b3fde73a749 |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-17T12:59:35Z |
| publishDate | 2009-05-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-e19991c4077b4960b58c7b3fde73a7492022-12-21T21:47:24ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222009-05-01672137145Malignant pleural mesothelioma: Clinicopathologic and survival characteristic in a consecutive series of 40 patientsBagheri RHaghy SZRahim MBAttaran DSilanian Toosi M"n Normal 0 false false false EN-GB X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Pleural malignant mesothelioma is an uncommon but extremely invasive tumor which originates from mesothelial cells and usually occures after prolonged exposure to asbestos. The aim of this study was to clinicopathologically evaluation of 40 patients with pleural malignant mesothelioma and the main factors influencing their prognosis. "n"n Methods: In this study patients with definitive diagnosis, who had been followed up for at least three years were studied based on gender, age presenting symptoms, and clinicopathological patterns."n"n Results: Male to female ratio of the study patients was three to one any the average age of them was 55 years. Chest pain was the most common symptoms in 34(85%) patients. Most of the study patients were in Buchard stage I (37/5%) and the epithelial form was the most common pathological pattern 25(62.5%). 19(47.5%) of cases received only radiotherapy and chemotherapy. Extrapleural pneumonectomy was performed on eight (20%) patients, seven (17.5%) patients underwent decortication and pleurectomy beside adjuvant therapy and 15% of the cases rejected any type of treatment. Surgical mortality occurred in one patient and the most common surgical complication was wound infection. The average survival rate was 12±1.2 months and the main factors influencing it were the patient's physiologic status, pathological form, stage of the disease and the pattern of pleural involvement. "n"n Conclusions: Because the low survival rate after multimodality invasive treatments in mesothelioma, aggressive therapeutic methods were recommended in selected patientshttp://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/13598.pdf&manuscript_id=13598Malignant mestheliomapleuradiagnosistreatment |
| spellingShingle | Bagheri R Haghy SZ Rahim MB Attaran D Silanian Toosi M Malignant pleural mesothelioma: Clinicopathologic and survival characteristic in a consecutive series of 40 patients Tehran University Medical Journal Malignant mesthelioma pleura diagnosis treatment |
| title | Malignant pleural mesothelioma: Clinicopathologic and survival characteristic in a consecutive series of 40 patients |
| title_full | Malignant pleural mesothelioma: Clinicopathologic and survival characteristic in a consecutive series of 40 patients |
| title_fullStr | Malignant pleural mesothelioma: Clinicopathologic and survival characteristic in a consecutive series of 40 patients |
| title_full_unstemmed | Malignant pleural mesothelioma: Clinicopathologic and survival characteristic in a consecutive series of 40 patients |
| title_short | Malignant pleural mesothelioma: Clinicopathologic and survival characteristic in a consecutive series of 40 patients |
| title_sort | malignant pleural mesothelioma clinicopathologic and survival characteristic in a consecutive series of 40 patients |
| topic | Malignant mesthelioma pleura diagnosis treatment |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/13598.pdf&manuscript_id=13598 |
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