Correlation of photoreceptor damage with anti-retina antibodies level in aqueous humor in macular edema patients
Abstract This study aimed to investigate the correlation between the severity of photoreceptor damage and the level of anti-retina antibodies (ARAs) in aqueous humor, including recoverin, CA II and enolase-α IgG antibody of macular edema patients. Aqueous humor samples were collected from macular ed...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25875-y |
| _version_ | 1811188240257908736 |
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| author | Xinyao Han Linqi Zhang Jiyang Tang Zongyi Wang Siying Li Li Yuan Jinfeng Qu |
| author_facet | Xinyao Han Linqi Zhang Jiyang Tang Zongyi Wang Siying Li Li Yuan Jinfeng Qu |
| author_sort | Xinyao Han |
| collection | DOAJ |
| description | Abstract This study aimed to investigate the correlation between the severity of photoreceptor damage and the level of anti-retina antibodies (ARAs) in aqueous humor, including recoverin, CA II and enolase-α IgG antibody of macular edema patients. Aqueous humor samples were collected from macular edema patients and from cataract patients. Patients were divided into three groups according to the severity of discontinuity of ellipsoid zone (EZ) shown on optical coherence tomography (OCT) imaging: cataract patients with intact EZ, macular edema patients with mild EZ damage, and macular edema patients with severe EZ damage. The level of ARAs was determined with enzyme-linked immunosorbent assay (ELISA). The correlation between the level of ARAs and the degree of photoreceptor damage was analyzed. The level of ARAs of the intact EZ group was significantly lower than that in the severely damaged group (P < 0.05). The level of recoverin IgG of the intact EZ group was significantly lower than mildly damaged group (P = 0.030). In a subgroup analysis, the level of recoverin IgG of DME patients was correlated with their central retinal thickness (CRT) (r = 0.462, P = 0.035). The level of ARAs in aqueous humor of patients with DME and RVO-ME was correlated with the degree of photoreceptor damage. |
| first_indexed | 2024-04-11T14:16:56Z |
| format | Article |
| id | doaj.art-e19a9a0a991b4abe9d2cc7b005be747c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T14:16:56Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e19a9a0a991b4abe9d2cc7b005be747c2022-12-22T04:19:24ZengNature PortfolioScientific Reports2045-23222022-12-011211610.1038/s41598-022-25875-yCorrelation of photoreceptor damage with anti-retina antibodies level in aqueous humor in macular edema patientsXinyao Han0Linqi Zhang1Jiyang Tang2Zongyi Wang3Siying Li4Li Yuan5Jinfeng Qu6Department of Ophthalmology, Eye Diseases and Optometry Institute, Peking University People’s HospitalDepartment of Ophthalmology, Eye Diseases and Optometry Institute, Peking University People’s HospitalDepartment of Ophthalmology, Eye Diseases and Optometry Institute, Peking University People’s HospitalDepartment of Ophthalmology, Eye Diseases and Optometry Institute, Peking University People’s HospitalDepartment of Ophthalmology, Eye Diseases and Optometry Institute, Peking University People’s HospitalDepartment of Ophthalmology, Eye Diseases and Optometry Institute, Peking University People’s HospitalDepartment of Ophthalmology, Eye Diseases and Optometry Institute, Peking University People’s HospitalAbstract This study aimed to investigate the correlation between the severity of photoreceptor damage and the level of anti-retina antibodies (ARAs) in aqueous humor, including recoverin, CA II and enolase-α IgG antibody of macular edema patients. Aqueous humor samples were collected from macular edema patients and from cataract patients. Patients were divided into three groups according to the severity of discontinuity of ellipsoid zone (EZ) shown on optical coherence tomography (OCT) imaging: cataract patients with intact EZ, macular edema patients with mild EZ damage, and macular edema patients with severe EZ damage. The level of ARAs was determined with enzyme-linked immunosorbent assay (ELISA). The correlation between the level of ARAs and the degree of photoreceptor damage was analyzed. The level of ARAs of the intact EZ group was significantly lower than that in the severely damaged group (P < 0.05). The level of recoverin IgG of the intact EZ group was significantly lower than mildly damaged group (P = 0.030). In a subgroup analysis, the level of recoverin IgG of DME patients was correlated with their central retinal thickness (CRT) (r = 0.462, P = 0.035). The level of ARAs in aqueous humor of patients with DME and RVO-ME was correlated with the degree of photoreceptor damage.https://doi.org/10.1038/s41598-022-25875-y |
| spellingShingle | Xinyao Han Linqi Zhang Jiyang Tang Zongyi Wang Siying Li Li Yuan Jinfeng Qu Correlation of photoreceptor damage with anti-retina antibodies level in aqueous humor in macular edema patients Scientific Reports |
| title | Correlation of photoreceptor damage with anti-retina antibodies level in aqueous humor in macular edema patients |
| title_full | Correlation of photoreceptor damage with anti-retina antibodies level in aqueous humor in macular edema patients |
| title_fullStr | Correlation of photoreceptor damage with anti-retina antibodies level in aqueous humor in macular edema patients |
| title_full_unstemmed | Correlation of photoreceptor damage with anti-retina antibodies level in aqueous humor in macular edema patients |
| title_short | Correlation of photoreceptor damage with anti-retina antibodies level in aqueous humor in macular edema patients |
| title_sort | correlation of photoreceptor damage with anti retina antibodies level in aqueous humor in macular edema patients |
| url | https://doi.org/10.1038/s41598-022-25875-y |
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