A Review Into the Insights of the Role of Endothelial Progenitor Cells on Bone Biology
In addition to its important transport functions, the skeletal system is involved in complex biological activities for the regulation of blood vessels. Endothelial progenitor cells (EPCs), as stem cells of endothelial cells (ECs), possess an effective proliferative capacity and a powerful angiogenic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.878697/full |
| _version_ | 1818006374280331264 |
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| author | Henglei Shi Henglei Shi Zhenchen Zhao Zhenchen Zhao Weidong Jiang Weidong Jiang Peiqi Zhu Peiqi Zhu Nuo Zhou Nuo Zhou Xuanping Huang Xuanping Huang |
| author_facet | Henglei Shi Henglei Shi Zhenchen Zhao Zhenchen Zhao Weidong Jiang Weidong Jiang Peiqi Zhu Peiqi Zhu Nuo Zhou Nuo Zhou Xuanping Huang Xuanping Huang |
| author_sort | Henglei Shi |
| collection | DOAJ |
| description | In addition to its important transport functions, the skeletal system is involved in complex biological activities for the regulation of blood vessels. Endothelial progenitor cells (EPCs), as stem cells of endothelial cells (ECs), possess an effective proliferative capacity and a powerful angiogenic capacity prior to their differentiation. They demonstrate synergistic effects to promote bone regeneration and vascularization more effectively by co-culturing with multiple cells. EPCs demonstrate a significant therapeutic potential for the treatment of various bone diseases by secreting a combination of growth factors, regulating cellular functions, and promoting bone regeneration. In this review, we retrospect the definition and properties of EPCs, their interaction with mesenchymal stem cells, ECs, smooth muscle cells, and immune cells in bone regeneration, vascularization, and immunity, summarizing their mechanism of action and contribution to bone biology. Additionally, we generalized their role and potential mechanisms in the treatment of various bone diseases, possibly indicating their clinical application. |
| first_indexed | 2024-04-14T05:00:12Z |
| format | Article |
| id | doaj.art-e19c19368a6d4881a5725943d4389999 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-14T05:00:12Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-e19c19368a6d4881a5725943d43899992022-12-22T02:11:00ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-05-011010.3389/fcell.2022.878697878697A Review Into the Insights of the Role of Endothelial Progenitor Cells on Bone BiologyHenglei Shi0Henglei Shi1Zhenchen Zhao2Zhenchen Zhao3Weidong Jiang4Weidong Jiang5Peiqi Zhu6Peiqi Zhu7Nuo Zhou8Nuo Zhou9Xuanping Huang10Xuanping Huang11Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Disease Treatment, Guangxi Clinical Research Center for Craniofacia Reconstruction, Guangxi Key Laboratory of Oral and Maxillofacial Surg Deformity, Nanning, ChinaDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Disease Treatment, Guangxi Clinical Research Center for Craniofacia Reconstruction, Guangxi Key Laboratory of Oral and Maxillofacial Surg Deformity, Nanning, ChinaDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Disease Treatment, Guangxi Clinical Research Center for Craniofacia Reconstruction, Guangxi Key Laboratory of Oral and Maxillofacial Surg Deformity, Nanning, ChinaDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Disease Treatment, Guangxi Clinical Research Center for Craniofacia Reconstruction, Guangxi Key Laboratory of Oral and Maxillofacial Surg Deformity, Nanning, ChinaDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Disease Treatment, Guangxi Clinical Research Center for Craniofacia Reconstruction, Guangxi Key Laboratory of Oral and Maxillofacial Surg Deformity, Nanning, ChinaDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Disease Treatment, Guangxi Clinical Research Center for Craniofacia Reconstruction, Guangxi Key Laboratory of Oral and Maxillofacial Surg Deformity, Nanning, ChinaIn addition to its important transport functions, the skeletal system is involved in complex biological activities for the regulation of blood vessels. Endothelial progenitor cells (EPCs), as stem cells of endothelial cells (ECs), possess an effective proliferative capacity and a powerful angiogenic capacity prior to their differentiation. They demonstrate synergistic effects to promote bone regeneration and vascularization more effectively by co-culturing with multiple cells. EPCs demonstrate a significant therapeutic potential for the treatment of various bone diseases by secreting a combination of growth factors, regulating cellular functions, and promoting bone regeneration. In this review, we retrospect the definition and properties of EPCs, their interaction with mesenchymal stem cells, ECs, smooth muscle cells, and immune cells in bone regeneration, vascularization, and immunity, summarizing their mechanism of action and contribution to bone biology. Additionally, we generalized their role and potential mechanisms in the treatment of various bone diseases, possibly indicating their clinical application.https://www.frontiersin.org/articles/10.3389/fcell.2022.878697/fullendothelial progenitor cellsbone biologybone regenerationbone vascularizationbone immunityinteraction |
| spellingShingle | Henglei Shi Henglei Shi Zhenchen Zhao Zhenchen Zhao Weidong Jiang Weidong Jiang Peiqi Zhu Peiqi Zhu Nuo Zhou Nuo Zhou Xuanping Huang Xuanping Huang A Review Into the Insights of the Role of Endothelial Progenitor Cells on Bone Biology Frontiers in Cell and Developmental Biology endothelial progenitor cells bone biology bone regeneration bone vascularization bone immunity interaction |
| title | A Review Into the Insights of the Role of Endothelial Progenitor Cells on Bone Biology |
| title_full | A Review Into the Insights of the Role of Endothelial Progenitor Cells on Bone Biology |
| title_fullStr | A Review Into the Insights of the Role of Endothelial Progenitor Cells on Bone Biology |
| title_full_unstemmed | A Review Into the Insights of the Role of Endothelial Progenitor Cells on Bone Biology |
| title_short | A Review Into the Insights of the Role of Endothelial Progenitor Cells on Bone Biology |
| title_sort | review into the insights of the role of endothelial progenitor cells on bone biology |
| topic | endothelial progenitor cells bone biology bone regeneration bone vascularization bone immunity interaction |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.878697/full |
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