SFRP2 Overexpression Induces an Osteoblast-like Phenotype in Prostate Cancer Cells
Prostate cancer bone metastasis is still one of the most fatal cancer diagnoses for men. Survival of the circulating prostate tumor cells and their adaptation strategy to survive in the bone niche is the key point to determining metastasis in early cancer stages. The promoter of <i>SFRP2</i...
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MDPI AG
2022-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/24/4081 |
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| author | Elif Akova Ölken Attila Aszodi Hanna Taipaleenmäki Hiroaki Saito Veronika Schönitzer Michael Chaloupka Maria Apfelbeck Wolfgang Böcker Maximilian Michael Saller |
| author_facet | Elif Akova Ölken Attila Aszodi Hanna Taipaleenmäki Hiroaki Saito Veronika Schönitzer Michael Chaloupka Maria Apfelbeck Wolfgang Böcker Maximilian Michael Saller |
| author_sort | Elif Akova Ölken |
| collection | DOAJ |
| description | Prostate cancer bone metastasis is still one of the most fatal cancer diagnoses for men. Survival of the circulating prostate tumor cells and their adaptation strategy to survive in the bone niche is the key point to determining metastasis in early cancer stages. The promoter of <i>SFRP2</i> gene, encoding a WNT signaling modulator, is hypermethylated in many cancer types including prostate cancer. Moreover, SFRP2 can positively regulate osteogenic differentiation in vitro and in vivo. Here, we showed SFRP2 overexpression in the prostate cancer cell line PC3 induces an epithelial mesenchymal transition (EMT), increases the attachment, and modifies the transcriptome towards an osteoblast-like phenotype (osteomimicry) in a collagen 1-dependent manner. Our data reflect a novel molecular mechanism concerning how metastasizing prostate cancer cells might increase their chance to survive within bone tissue. |
| first_indexed | 2024-03-09T17:12:48Z |
| format | Article |
| id | doaj.art-e19c6cd467164e86b2736e2ce4c19eb7 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T17:12:48Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e19c6cd467164e86b2736e2ce4c19eb72023-11-24T13:55:28ZengMDPI AGCells2073-44092022-12-011124408110.3390/cells11244081SFRP2 Overexpression Induces an Osteoblast-like Phenotype in Prostate Cancer CellsElif Akova Ölken0Attila Aszodi1Hanna Taipaleenmäki2Hiroaki Saito3Veronika Schönitzer4Michael Chaloupka5Maria Apfelbeck6Wolfgang Böcker7Maximilian Michael Saller8Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), Ludwig-Maximilians-University (LMU) Hospital, Fraunhoferstraße 20, 82152 Planegg-Martinsried, GermanyDepartment of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), Ludwig-Maximilians-University (LMU) Hospital, Fraunhoferstraße 20, 82152 Planegg-Martinsried, GermanyInstitute of Musculoskeletal Medicine (IMM), Musculoskeletal University Center Munich (MUM), LMU Hospital, Fraunhoferstraße 20, 82152 Planegg-Martinsried, GermanyInstitute of Musculoskeletal Medicine (IMM), Musculoskeletal University Center Munich (MUM), LMU Hospital, Fraunhoferstraße 20, 82152 Planegg-Martinsried, GermanyDepartment of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), Ludwig-Maximilians-University (LMU) Hospital, Fraunhoferstraße 20, 82152 Planegg-Martinsried, GermanyUrologischen Klinik und Poliklinik, LMU Hospital, Marchioninistr 15, 81377 München, GermanyUrologischen Klinik und Poliklinik, LMU Hospital, Marchioninistr 15, 81377 München, GermanyDepartment of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), Ludwig-Maximilians-University (LMU) Hospital, Fraunhoferstraße 20, 82152 Planegg-Martinsried, GermanyDepartment of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), Ludwig-Maximilians-University (LMU) Hospital, Fraunhoferstraße 20, 82152 Planegg-Martinsried, GermanyProstate cancer bone metastasis is still one of the most fatal cancer diagnoses for men. Survival of the circulating prostate tumor cells and their adaptation strategy to survive in the bone niche is the key point to determining metastasis in early cancer stages. The promoter of <i>SFRP2</i> gene, encoding a WNT signaling modulator, is hypermethylated in many cancer types including prostate cancer. Moreover, SFRP2 can positively regulate osteogenic differentiation in vitro and in vivo. Here, we showed SFRP2 overexpression in the prostate cancer cell line PC3 induces an epithelial mesenchymal transition (EMT), increases the attachment, and modifies the transcriptome towards an osteoblast-like phenotype (osteomimicry) in a collagen 1-dependent manner. Our data reflect a novel molecular mechanism concerning how metastasizing prostate cancer cells might increase their chance to survive within bone tissue.https://www.mdpi.com/2073-4409/11/24/4081SFRP2osteomimicryprostate cancerPC3bone metastasisEMT |
| spellingShingle | Elif Akova Ölken Attila Aszodi Hanna Taipaleenmäki Hiroaki Saito Veronika Schönitzer Michael Chaloupka Maria Apfelbeck Wolfgang Böcker Maximilian Michael Saller SFRP2 Overexpression Induces an Osteoblast-like Phenotype in Prostate Cancer Cells Cells SFRP2 osteomimicry prostate cancer PC3 bone metastasis EMT |
| title | SFRP2 Overexpression Induces an Osteoblast-like Phenotype in Prostate Cancer Cells |
| title_full | SFRP2 Overexpression Induces an Osteoblast-like Phenotype in Prostate Cancer Cells |
| title_fullStr | SFRP2 Overexpression Induces an Osteoblast-like Phenotype in Prostate Cancer Cells |
| title_full_unstemmed | SFRP2 Overexpression Induces an Osteoblast-like Phenotype in Prostate Cancer Cells |
| title_short | SFRP2 Overexpression Induces an Osteoblast-like Phenotype in Prostate Cancer Cells |
| title_sort | sfrp2 overexpression induces an osteoblast like phenotype in prostate cancer cells |
| topic | SFRP2 osteomimicry prostate cancer PC3 bone metastasis EMT |
| url | https://www.mdpi.com/2073-4409/11/24/4081 |
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