Incidence and Risk of Anti-Resorptive Agent-Related Osteonecrosis of the Jaw after Tooth Extraction: A Retrospective Study
Bone-modifying agents (BMA) such as bisphosphonates and denosumab are frequently used for the treatment of bone metastases, osteoporosis, and multiple myeloma. BMA may lead to anti-resorptive agent-related osteonecrosis of the jaw (ARONJ). This study aimed to clarify the risk factors for and probabi...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/10/7/1332 |
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| author | Rieko Shimizu Shintaro Sukegawa Yuka Sukegawa Kazuaki Hasegawa Sawako Ono Tomoya Nakamura Ai Fujimura Ayaka Fujisawa Keisuke Nakano Kiyofumi Takabatake Hotaka Kawai Hitoshi Nagatsuka Yoshihiko Furuki |
| author_facet | Rieko Shimizu Shintaro Sukegawa Yuka Sukegawa Kazuaki Hasegawa Sawako Ono Tomoya Nakamura Ai Fujimura Ayaka Fujisawa Keisuke Nakano Kiyofumi Takabatake Hotaka Kawai Hitoshi Nagatsuka Yoshihiko Furuki |
| author_sort | Rieko Shimizu |
| collection | DOAJ |
| description | Bone-modifying agents (BMA) such as bisphosphonates and denosumab are frequently used for the treatment of bone metastases, osteoporosis, and multiple myeloma. BMA may lead to anti-resorptive agent-related osteonecrosis of the jaw (ARONJ). This study aimed to clarify the risk factors for and probabilities of developing ARONJ after tooth extraction in patients undergoing BMA therapy. In this study, the records of 505 target sites of 302 patients undergoing BMA who presented with mandibular fractures at the Department of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, from March 2014 to January 2022, were retrospectively analyzed for the onset of ARONJ after tooth extraction. The following variables were investigated as attributes: anatomy, health status, and dental treatment. The correlation coefficient was calculated for the success or failure of endodontic surgery for each variable, the odds ratio was calculated for the upper variable, and the factors related to the onset of ARONJ were identified. The incidence rate of ARONJ was found to be 3.2%. Hypoparathyroidism was an important factor associated with ARONJ development. Thus, systemic factors are more strongly related to the onset of ARONJ after tooth extraction than local factors. |
| first_indexed | 2024-03-09T03:22:55Z |
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| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-09T03:22:55Z |
| publishDate | 2022-07-01 |
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| series | Healthcare |
| spelling | doaj.art-e19cc1a506f546d685a0702e81a3b7912023-12-03T15:07:51ZengMDPI AGHealthcare2227-90322022-07-01107133210.3390/healthcare10071332Incidence and Risk of Anti-Resorptive Agent-Related Osteonecrosis of the Jaw after Tooth Extraction: A Retrospective StudyRieko Shimizu0Shintaro Sukegawa1Yuka Sukegawa2Kazuaki Hasegawa3Sawako Ono4Tomoya Nakamura5Ai Fujimura6Ayaka Fujisawa7Keisuke Nakano8Kiyofumi Takabatake9Hotaka Kawai10Hitoshi Nagatsuka11Yoshihiko Furuki12Department of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, Takamatsu 760-8557, JapanDepartment of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, Takamatsu 760-8557, JapanDepartment of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, Takamatsu 760-8557, JapanDepartment of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, Takamatsu 760-8557, JapanDepartment of Pathology, Kagawa Prefectural Central Hospital, Takamatsu 760-8557, JapanDepartment of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, Takamatsu 760-8557, JapanDepartment of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, Takamatsu 760-8557, JapanDepartment of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, Takamatsu 760-8557, JapanDepartment of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, JapanDepartment of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, JapanDepartment of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, JapanDepartment of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, JapanDepartment of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, Takamatsu 760-8557, JapanBone-modifying agents (BMA) such as bisphosphonates and denosumab are frequently used for the treatment of bone metastases, osteoporosis, and multiple myeloma. BMA may lead to anti-resorptive agent-related osteonecrosis of the jaw (ARONJ). This study aimed to clarify the risk factors for and probabilities of developing ARONJ after tooth extraction in patients undergoing BMA therapy. In this study, the records of 505 target sites of 302 patients undergoing BMA who presented with mandibular fractures at the Department of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, from March 2014 to January 2022, were retrospectively analyzed for the onset of ARONJ after tooth extraction. The following variables were investigated as attributes: anatomy, health status, and dental treatment. The correlation coefficient was calculated for the success or failure of endodontic surgery for each variable, the odds ratio was calculated for the upper variable, and the factors related to the onset of ARONJ were identified. The incidence rate of ARONJ was found to be 3.2%. Hypoparathyroidism was an important factor associated with ARONJ development. Thus, systemic factors are more strongly related to the onset of ARONJ after tooth extraction than local factors.https://www.mdpi.com/2227-9032/10/7/1332anti-resorptive agent-related osteonecrosis of the jawbisphosphonatedenosumabretrospective studyrisk factortooth extraction |
| spellingShingle | Rieko Shimizu Shintaro Sukegawa Yuka Sukegawa Kazuaki Hasegawa Sawako Ono Tomoya Nakamura Ai Fujimura Ayaka Fujisawa Keisuke Nakano Kiyofumi Takabatake Hotaka Kawai Hitoshi Nagatsuka Yoshihiko Furuki Incidence and Risk of Anti-Resorptive Agent-Related Osteonecrosis of the Jaw after Tooth Extraction: A Retrospective Study Healthcare anti-resorptive agent-related osteonecrosis of the jaw bisphosphonate denosumab retrospective study risk factor tooth extraction |
| title | Incidence and Risk of Anti-Resorptive Agent-Related Osteonecrosis of the Jaw after Tooth Extraction: A Retrospective Study |
| title_full | Incidence and Risk of Anti-Resorptive Agent-Related Osteonecrosis of the Jaw after Tooth Extraction: A Retrospective Study |
| title_fullStr | Incidence and Risk of Anti-Resorptive Agent-Related Osteonecrosis of the Jaw after Tooth Extraction: A Retrospective Study |
| title_full_unstemmed | Incidence and Risk of Anti-Resorptive Agent-Related Osteonecrosis of the Jaw after Tooth Extraction: A Retrospective Study |
| title_short | Incidence and Risk of Anti-Resorptive Agent-Related Osteonecrosis of the Jaw after Tooth Extraction: A Retrospective Study |
| title_sort | incidence and risk of anti resorptive agent related osteonecrosis of the jaw after tooth extraction a retrospective study |
| topic | anti-resorptive agent-related osteonecrosis of the jaw bisphosphonate denosumab retrospective study risk factor tooth extraction |
| url | https://www.mdpi.com/2227-9032/10/7/1332 |
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