Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila
Developmental studies revealed fundamental principles on how organ size and function is achieved, but less is known about organ adaptation to new physiological demands. In fruit flies, juvenile hormone (JH) induces intestinal stem cell (ISC) driven absorptive epithelial expansion balancing energy up...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/55795 |
| _version_ | 1811180573741285376 |
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| author | Lisa Zipper Denise Jassmann Sofie Burgmer Bastian Görlich Tobias Reiff |
| author_facet | Lisa Zipper Denise Jassmann Sofie Burgmer Bastian Görlich Tobias Reiff |
| author_sort | Lisa Zipper |
| collection | DOAJ |
| description | Developmental studies revealed fundamental principles on how organ size and function is achieved, but less is known about organ adaptation to new physiological demands. In fruit flies, juvenile hormone (JH) induces intestinal stem cell (ISC) driven absorptive epithelial expansion balancing energy uptake with increased energy demands of pregnancy. Here, we show 20-Hydroxy-Ecdysone (20HE)-signaling controlling organ homeostasis with physiological and pathological implications. Upon mating, 20HE titer in ovaries and hemolymph are increased and act on nearby midgut progenitors inducing Ecdysone-induced-protein-75B (Eip75B). Strikingly, the PPARγ-homologue Eip75B drives ISC daughter cells towards absorptive enterocyte lineage ensuring epithelial growth. To our knowledge, this is the first time a systemic hormone is shown to direct local stem cell fate decisions. Given the protective, but mechanistically unclear role of steroid hormones in female colorectal cancer patients, our findings suggest a tumor-suppressive role for steroidal signaling by promoting postmitotic fate when local signaling is deteriorated. |
| first_indexed | 2024-04-11T09:04:22Z |
| format | Article |
| id | doaj.art-e19cd73d3ec946d68339435ff0c131dc |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:04:22Z |
| publishDate | 2020-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-e19cd73d3ec946d68339435ff0c131dc2022-12-22T04:32:40ZengeLife Sciences Publications LtdeLife2050-084X2020-08-01910.7554/eLife.55795Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in DrosophilaLisa Zipper0Denise Jassmann1Sofie Burgmer2Bastian Görlich3Tobias Reiff4https://orcid.org/0000-0001-6610-6148Institute of Genetics, Heinrich-Heine-University, Düsseldorf, GermanyInstitute of Genetics, Heinrich-Heine-University, Düsseldorf, GermanyInstitute of Genetics, Heinrich-Heine-University, Düsseldorf, GermanyInstitute of Genetics, Heinrich-Heine-University, Düsseldorf, GermanyInstitute of Genetics, Heinrich-Heine-University, Düsseldorf, GermanyDevelopmental studies revealed fundamental principles on how organ size and function is achieved, but less is known about organ adaptation to new physiological demands. In fruit flies, juvenile hormone (JH) induces intestinal stem cell (ISC) driven absorptive epithelial expansion balancing energy uptake with increased energy demands of pregnancy. Here, we show 20-Hydroxy-Ecdysone (20HE)-signaling controlling organ homeostasis with physiological and pathological implications. Upon mating, 20HE titer in ovaries and hemolymph are increased and act on nearby midgut progenitors inducing Ecdysone-induced-protein-75B (Eip75B). Strikingly, the PPARγ-homologue Eip75B drives ISC daughter cells towards absorptive enterocyte lineage ensuring epithelial growth. To our knowledge, this is the first time a systemic hormone is shown to direct local stem cell fate decisions. Given the protective, but mechanistically unclear role of steroid hormones in female colorectal cancer patients, our findings suggest a tumor-suppressive role for steroidal signaling by promoting postmitotic fate when local signaling is deteriorated.https://elifesciences.org/articles/55795intestinal stem cellsteroid hormonemidgutenteroblaste75b/pparecdysone |
| spellingShingle | Lisa Zipper Denise Jassmann Sofie Burgmer Bastian Görlich Tobias Reiff Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila eLife intestinal stem cell steroid hormone midgut enteroblast e75b/ppar ecdysone |
| title | Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila |
| title_full | Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila |
| title_fullStr | Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila |
| title_full_unstemmed | Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila |
| title_short | Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila |
| title_sort | ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the pparγ homolog eip75b in drosophila |
| topic | intestinal stem cell steroid hormone midgut enteroblast e75b/ppar ecdysone |
| url | https://elifesciences.org/articles/55795 |
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