USP8 regulates liver cancer progression via the inhibition of TRAF6-mediated signal for NF-κB activation and autophagy induction by TLR4

USP8 regulates liver cancer progression via the inhibition of TRAF6-mediated signal for NF-κB activation and autophagy induction by TLR4

Herein, we aimed to elucidate the molecular and cellular mechanism in which ubiquitin-specific protease 8 (USP8) is implicated in liver cancer progression via TRAF6-mediated signal. USP8 induces the deubiquitination of TRAF6, TAB2, TAK1, p62, and BECN1, which are pivotal roles for NF-κB activation a...

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Bibliographic Details
Main Authors: Mi-Jeong Kim, Bongkum Choi, Ji Young Kim, Yoon Min, Do Hee Kwon, Juhee Son, Ji Su Lee, Joo Sang Lee, Eunyoung Chun, Ki-Young Lee
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Translational Oncology
Subjects:
USP8
Autophagy
Toll-like receptor 4
TRAF6-mediated signal
Liver cancer progression
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321002424

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