Evaluation of Vitamin D Status in Newly Diagnosed Pemphigus Vulgaris Patients.
Pemphigus vulgaris (PV) is an autoimmune blistering disorder of the skin or mucosa. Since low vitamin D status has been linked to many immune disorders, we designed this study to compare the vitamin D status in PV patients with healthy controls.In this case-control study, vitamin D status of 32 newl...
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| Format: | Article |
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Tehran University of Medical Sciences
2014-11-01
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| Series: | Iranian Journal of Public Health |
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| Online Access: | https://ijph.tums.ac.ir/index.php/ijph/article/view/3833 |
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| author | Mahnaz Zarei Mohammad Hassan Javanbakht Cheida Chams-Davatchi Maryam Daneshpazhooh Mohammad Reza Eshraghian Hoda DE-Rakhshanian Mahmoud Djalali |
| author_facet | Mahnaz Zarei Mohammad Hassan Javanbakht Cheida Chams-Davatchi Maryam Daneshpazhooh Mohammad Reza Eshraghian Hoda DE-Rakhshanian Mahmoud Djalali |
| author_sort | Mahnaz Zarei |
| collection | DOAJ |
| description | Pemphigus vulgaris (PV) is an autoimmune blistering disorder of the skin or mucosa. Since low vitamin D status has been linked to many immune disorders, we designed this study to compare the vitamin D status in PV patients with healthy controls.In this case-control study, vitamin D status of 32 newly diagnosed PV patients was compared with 36 healthy control subjects. All patients were selected from the specialized dermatology departments of Razi Hospital, Tehran University of Medical Sciences in a 2-year period (2009-2010). The severity of the disease was estimated according to Harman's scores. Serum concentration of 25(OH)D was measured by Roche Elecsys System. Data were analyzed by independent t-test.Both groups were similar based on sex, age and body mass index. The mean duration of disease was 5.57±0.93 months. The mean oral and skin severities were 1.81±0.20 and 2.31±0.17 respectively, based on Harman's scores. Serum 25(OH)D was significantly lower in PV patients compared to controls (-8.90; 95% CI, 2.29-15.51 and P = 0.009). There was a negative correlation between vitamin D level and the oral severity of disease (r = -0.39 and P = 0.02).PV patients had significantly lower serum level of 25(OH)D compared to healthy subjects which might contribute to worsen the disease. These data indicate the importance of improving vitamin D level in pemphigus patients. |
| first_indexed | 2024-12-14T04:09:21Z |
| format | Article |
| id | doaj.art-e19e0d34618243f88ba4c9853658b36c |
| institution | Directory Open Access Journal |
| issn | 2251-6085 2251-6093 |
| language | English |
| last_indexed | 2024-12-14T04:09:21Z |
| publishDate | 2014-11-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-e19e0d34618243f88ba4c9853658b36c2022-12-21T23:17:43ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932014-11-0143113689Evaluation of Vitamin D Status in Newly Diagnosed Pemphigus Vulgaris Patients.Mahnaz Zarei0Mohammad Hassan Javanbakht1Cheida Chams-Davatchi2Maryam Daneshpazhooh3Mohammad Reza Eshraghian4Hoda DE-Rakhshanian5Mahmoud Djalali61. Dept. of Cellular and Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences , Tehran, Iran.1. Dept. of Cellular and Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences , Tehran, Iran.2. Autoimmune Bullous Diseases Research Center, Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences , Tehran, Iran.2. Autoimmune Bullous Diseases Research Center, Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences , Tehran, Iran.3. Dept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran.1. Dept. of Cellular and Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences , Tehran, Iran.1. Dept. of Cellular and Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences , Tehran, Iran.Pemphigus vulgaris (PV) is an autoimmune blistering disorder of the skin or mucosa. Since low vitamin D status has been linked to many immune disorders, we designed this study to compare the vitamin D status in PV patients with healthy controls.In this case-control study, vitamin D status of 32 newly diagnosed PV patients was compared with 36 healthy control subjects. All patients were selected from the specialized dermatology departments of Razi Hospital, Tehran University of Medical Sciences in a 2-year period (2009-2010). The severity of the disease was estimated according to Harman's scores. Serum concentration of 25(OH)D was measured by Roche Elecsys System. Data were analyzed by independent t-test.Both groups were similar based on sex, age and body mass index. The mean duration of disease was 5.57±0.93 months. The mean oral and skin severities were 1.81±0.20 and 2.31±0.17 respectively, based on Harman's scores. Serum 25(OH)D was significantly lower in PV patients compared to controls (-8.90; 95% CI, 2.29-15.51 and P = 0.009). There was a negative correlation between vitamin D level and the oral severity of disease (r = -0.39 and P = 0.02).PV patients had significantly lower serum level of 25(OH)D compared to healthy subjects which might contribute to worsen the disease. These data indicate the importance of improving vitamin D level in pemphigus patients.https://ijph.tums.ac.ir/index.php/ijph/article/view/3833CalcitriolPemphigus vulgarisVitamin D |
| spellingShingle | Mahnaz Zarei Mohammad Hassan Javanbakht Cheida Chams-Davatchi Maryam Daneshpazhooh Mohammad Reza Eshraghian Hoda DE-Rakhshanian Mahmoud Djalali Evaluation of Vitamin D Status in Newly Diagnosed Pemphigus Vulgaris Patients. Iranian Journal of Public Health Calcitriol Pemphigus vulgaris Vitamin D |
| title | Evaluation of Vitamin D Status in Newly Diagnosed Pemphigus Vulgaris Patients. |
| title_full | Evaluation of Vitamin D Status in Newly Diagnosed Pemphigus Vulgaris Patients. |
| title_fullStr | Evaluation of Vitamin D Status in Newly Diagnosed Pemphigus Vulgaris Patients. |
| title_full_unstemmed | Evaluation of Vitamin D Status in Newly Diagnosed Pemphigus Vulgaris Patients. |
| title_short | Evaluation of Vitamin D Status in Newly Diagnosed Pemphigus Vulgaris Patients. |
| title_sort | evaluation of vitamin d status in newly diagnosed pemphigus vulgaris patients |
| topic | Calcitriol Pemphigus vulgaris Vitamin D |
| url | https://ijph.tums.ac.ir/index.php/ijph/article/view/3833 |
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