DAPK3 participates in the mRNA processing of immediate early genes in chronic lymphocytic leukaemia

DAPK3 participates in the mRNA processing of immediate early genes in chronic lymphocytic leukaemia

Cross‐linking of the B‐cell receptor (BCR) induces transcriptional activation of immediate early genes (IEGs) including EGR1 and DUSP2 in chronic lymphocytic leukaemia (CLL). Here, we have shown that this transcriptional activation correlated with histone H3 threonine 6 and 11 phosphorylation. Both...

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Bibliographic Details
Main Authors: Fraser Thomas, Katie B. Holmes, Sarah Kreuz, Peter Hillmen, Pascal F. Lefevre
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Molecular Oncology
Subjects:
CLL
DAPK3
H3T11
histone phosphorylation
Ibrutinib
mRNA processing
Online Access:https://doi.org/10.1002/1878-0261.12692

Internet

https://doi.org/10.1002/1878-0261.12692

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