Synthesis and Biological Evaluation of Metronidazole Derivatives as Anti-Giardia Agents
<p align="justify">Nitroimidazole derivatives such as Metronidazole (MTZ) have been used as anti- protozoa and anti-anaerobic bacteria. In this study several compounds of MTZ derivatives were synthesized and evaluated against <em>Giardia lamblia cyst</em>. Firs MTZ were r...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2015-05-01
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| Series: | Trends in Pharmaceutical Sciences |
| Online Access: | http://tips.sums.ac.ir/index.php/TiPS/article/view/34 |
| Summary: | <p align="justify">Nitroimidazole derivatives such as Metronidazole (MTZ) have been used as anti- protozoa and anti-anaerobic bacteria. In this study several compounds of MTZ derivatives were synthesized and evaluated against <em>Giardia lamblia cyst</em>. Firs MTZ were reacted with several alkyl halide to obtain O-alkyl MTZ derivatives, then products were purified and their chemical structures were confirmed by elemental and spectral analysis (<sup>1</sup>HNMR and Mass). In order to biological evaluation all compounds were investigated against 25 Giardia samples isolated from giarfdiasis patients. Results showed compound <strong>2a</strong> had the most activity on cyst of Giardia in comparison with MTZ.</p> |
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| ISSN: | 2423-3722 2423-5652 |