<i>TREX1</i> 531C/T Polymorphism and Autoantibodies Associated with the Immune Status of HIV-1-Infected Individuals
Autoimmune diseases can develop during HIV-1 infection, mainly related to the individual’s immune competence. The study investigated the association of the <i>TREX1</i> 531C/T polymorphism and antinuclear antibodies (ANA) in HIV-1 infection and the time of antiretroviral therapy (ART) us...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/11/9660 |
| _version_ | 1797597358440054784 |
|---|---|
| author | Maria Alice Freitas Queiroz Tuane Carolina Ferreira Moura Carlos David Araújo Bichara Lorena Leticia Peixoto de Lima Allysson Quintino Tenório de Oliveira Ranilda Gama de Souza Samara Tatielle Monteiro Gomes Ednelza da Silva Graça Amoras Antonio Carlos Rosário Vallinoto |
| author_facet | Maria Alice Freitas Queiroz Tuane Carolina Ferreira Moura Carlos David Araújo Bichara Lorena Leticia Peixoto de Lima Allysson Quintino Tenório de Oliveira Ranilda Gama de Souza Samara Tatielle Monteiro Gomes Ednelza da Silva Graça Amoras Antonio Carlos Rosário Vallinoto |
| author_sort | Maria Alice Freitas Queiroz |
| collection | DOAJ |
| description | Autoimmune diseases can develop during HIV-1 infection, mainly related to the individual’s immune competence. The study investigated the association of the <i>TREX1</i> 531C/T polymorphism and antinuclear antibodies (ANA) in HIV-1 infection and the time of antiretroviral therapy (ART) used. Cross-sectional and longitudinal assessments were carried out in 150 individuals, divided into three groups: ART-naïve, 5 years and 10 years on ART; ART-naïve individuals were evaluated for 2 years after initiation of treatment. The individuals’ blood samples were submitted to indirect immunofluorescence tests, real-time PCR and flow cytometry. The <i>TREX1</i> 531C/T polymorphism was associated with higher levels of TCD4<sup>+</sup> lymphocytes and IFN-α in individuals with HIV-1. Individuals on ART had a higher frequency of ANA, higher levels of T CD4<sup>+</sup> lymphocytes, a higher ratio of T CD4<sup>+</sup>/CD8<sup>+</sup> lymphocytes and higher levels of IFN-α than therapy-naïve individuals (<i>p</i> < 0.05). The <i>TREX1</i> 531C/T polymorphism was associated with better maintenance of the immune status of individuals with HIV-1 and ANA with immune restoration in individuals on ART, indicating the need to identify individuals at risk of developing an autoimmune disease. |
| first_indexed | 2024-03-11T03:05:06Z |
| format | Article |
| id | doaj.art-e1a32c9f6cc14a578421df94de65fbee |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:05:06Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e1a32c9f6cc14a578421df94de65fbee2023-11-18T08:02:12ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-012411966010.3390/ijms24119660<i>TREX1</i> 531C/T Polymorphism and Autoantibodies Associated with the Immune Status of HIV-1-Infected IndividualsMaria Alice Freitas Queiroz0Tuane Carolina Ferreira Moura1Carlos David Araújo Bichara2Lorena Leticia Peixoto de Lima3Allysson Quintino Tenório de Oliveira4Ranilda Gama de Souza5Samara Tatielle Monteiro Gomes6Ednelza da Silva Graça Amoras7Antonio Carlos Rosário Vallinoto8Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, BrazilAutoimmune diseases can develop during HIV-1 infection, mainly related to the individual’s immune competence. The study investigated the association of the <i>TREX1</i> 531C/T polymorphism and antinuclear antibodies (ANA) in HIV-1 infection and the time of antiretroviral therapy (ART) used. Cross-sectional and longitudinal assessments were carried out in 150 individuals, divided into three groups: ART-naïve, 5 years and 10 years on ART; ART-naïve individuals were evaluated for 2 years after initiation of treatment. The individuals’ blood samples were submitted to indirect immunofluorescence tests, real-time PCR and flow cytometry. The <i>TREX1</i> 531C/T polymorphism was associated with higher levels of TCD4<sup>+</sup> lymphocytes and IFN-α in individuals with HIV-1. Individuals on ART had a higher frequency of ANA, higher levels of T CD4<sup>+</sup> lymphocytes, a higher ratio of T CD4<sup>+</sup>/CD8<sup>+</sup> lymphocytes and higher levels of IFN-α than therapy-naïve individuals (<i>p</i> < 0.05). The <i>TREX1</i> 531C/T polymorphism was associated with better maintenance of the immune status of individuals with HIV-1 and ANA with immune restoration in individuals on ART, indicating the need to identify individuals at risk of developing an autoimmune disease.https://www.mdpi.com/1422-0067/24/11/9660HIV-1TREX-1polymorphismARTautoantibodies |
| spellingShingle | Maria Alice Freitas Queiroz Tuane Carolina Ferreira Moura Carlos David Araújo Bichara Lorena Leticia Peixoto de Lima Allysson Quintino Tenório de Oliveira Ranilda Gama de Souza Samara Tatielle Monteiro Gomes Ednelza da Silva Graça Amoras Antonio Carlos Rosário Vallinoto <i>TREX1</i> 531C/T Polymorphism and Autoantibodies Associated with the Immune Status of HIV-1-Infected Individuals International Journal of Molecular Sciences HIV-1 TREX-1 polymorphism ART autoantibodies |
| title | <i>TREX1</i> 531C/T Polymorphism and Autoantibodies Associated with the Immune Status of HIV-1-Infected Individuals |
| title_full | <i>TREX1</i> 531C/T Polymorphism and Autoantibodies Associated with the Immune Status of HIV-1-Infected Individuals |
| title_fullStr | <i>TREX1</i> 531C/T Polymorphism and Autoantibodies Associated with the Immune Status of HIV-1-Infected Individuals |
| title_full_unstemmed | <i>TREX1</i> 531C/T Polymorphism and Autoantibodies Associated with the Immune Status of HIV-1-Infected Individuals |
| title_short | <i>TREX1</i> 531C/T Polymorphism and Autoantibodies Associated with the Immune Status of HIV-1-Infected Individuals |
| title_sort | i trex1 i 531c t polymorphism and autoantibodies associated with the immune status of hiv 1 infected individuals |
| topic | HIV-1 TREX-1 polymorphism ART autoantibodies |
| url | https://www.mdpi.com/1422-0067/24/11/9660 |
| work_keys_str_mv | AT mariaalicefreitasqueiroz itrex1i531ctpolymorphismandautoantibodiesassociatedwiththeimmunestatusofhiv1infectedindividuals AT tuanecarolinaferreiramoura itrex1i531ctpolymorphismandautoantibodiesassociatedwiththeimmunestatusofhiv1infectedindividuals AT carlosdavidaraujobichara itrex1i531ctpolymorphismandautoantibodiesassociatedwiththeimmunestatusofhiv1infectedindividuals AT lorenaleticiapeixotodelima itrex1i531ctpolymorphismandautoantibodiesassociatedwiththeimmunestatusofhiv1infectedindividuals AT allyssonquintinotenoriodeoliveira itrex1i531ctpolymorphismandautoantibodiesassociatedwiththeimmunestatusofhiv1infectedindividuals AT ranildagamadesouza itrex1i531ctpolymorphismandautoantibodiesassociatedwiththeimmunestatusofhiv1infectedindividuals AT samaratatiellemonteirogomes itrex1i531ctpolymorphismandautoantibodiesassociatedwiththeimmunestatusofhiv1infectedindividuals AT ednelzadasilvagracaamoras itrex1i531ctpolymorphismandautoantibodiesassociatedwiththeimmunestatusofhiv1infectedindividuals AT antoniocarlosrosariovallinoto itrex1i531ctpolymorphismandautoantibodiesassociatedwiththeimmunestatusofhiv1infectedindividuals |