Neuroinflammation, Sleep, and Circadian Rhythms
Molecules involved in innate immunity affect sleep and circadian oscillators and vice versa. Sleep-inducing inflammatory molecules are activated by increased waking activity and pathogens. Pathologies that alter inflammatory molecules, such as traumatic brain injury, cancer, cardiovascular disease,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.853096/full |
| _version_ | 1818485165299597312 |
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| author | Mark R. Zielinski Mark R. Zielinski Allison J. Gibbons |
| author_facet | Mark R. Zielinski Mark R. Zielinski Allison J. Gibbons |
| author_sort | Mark R. Zielinski |
| collection | DOAJ |
| description | Molecules involved in innate immunity affect sleep and circadian oscillators and vice versa. Sleep-inducing inflammatory molecules are activated by increased waking activity and pathogens. Pathologies that alter inflammatory molecules, such as traumatic brain injury, cancer, cardiovascular disease, and stroke often are associated with disturbed sleep and electroencephalogram power spectra. Moreover, sleep disorders, such as insomnia and sleep disordered breathing, are associated with increased dysregulation of inflammatory processes. Inflammatory molecules in both the central nervous system and periphery can alter sleep. Inflammation can also modulate cerebral vascular hemodynamics which is associated with alterations in electroencephalogram power spectra. However, further research is needed to determine the interactions of sleep regulatory inflammatory molecules and circadian clocks. The purpose of this review is to: 1) describe the role of the inflammatory cytokines interleukin-1 beta and tumor necrosis factor-alpha and nucleotide-binding domain and leucine-rich repeat protein-3 inflammasomes in sleep regulation, 2) to discuss the relationship between the vagus nerve in translating inflammatory signals between the periphery and central nervous system to alter sleep, and 3) to present information about the relationship between cerebral vascular hemodynamics and the electroencephalogram during sleep. |
| first_indexed | 2024-12-10T16:04:53Z |
| format | Article |
| id | doaj.art-e1a49ec9546c426b8cdd286404d541e9 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-10T16:04:53Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-e1a49ec9546c426b8cdd286404d541e92022-12-22T01:42:19ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-03-011210.3389/fcimb.2022.853096853096Neuroinflammation, Sleep, and Circadian RhythmsMark R. Zielinski0Mark R. Zielinski1Allison J. Gibbons2Veterans Affairs (VA) Boston Healthcare System, West Roxbury, MA, United StatesHarvard Medical School, West Roxbury, MA, United StatesVeterans Affairs (VA) Boston Healthcare System, West Roxbury, MA, United StatesMolecules involved in innate immunity affect sleep and circadian oscillators and vice versa. Sleep-inducing inflammatory molecules are activated by increased waking activity and pathogens. Pathologies that alter inflammatory molecules, such as traumatic brain injury, cancer, cardiovascular disease, and stroke often are associated with disturbed sleep and electroencephalogram power spectra. Moreover, sleep disorders, such as insomnia and sleep disordered breathing, are associated with increased dysregulation of inflammatory processes. Inflammatory molecules in both the central nervous system and periphery can alter sleep. Inflammation can also modulate cerebral vascular hemodynamics which is associated with alterations in electroencephalogram power spectra. However, further research is needed to determine the interactions of sleep regulatory inflammatory molecules and circadian clocks. The purpose of this review is to: 1) describe the role of the inflammatory cytokines interleukin-1 beta and tumor necrosis factor-alpha and nucleotide-binding domain and leucine-rich repeat protein-3 inflammasomes in sleep regulation, 2) to discuss the relationship between the vagus nerve in translating inflammatory signals between the periphery and central nervous system to alter sleep, and 3) to present information about the relationship between cerebral vascular hemodynamics and the electroencephalogram during sleep.https://www.frontiersin.org/articles/10.3389/fcimb.2022.853096/fullNLRP3 inflammasomecytokineselectroencephalogram powervagus nerveneurovascular unitinflammation |
| spellingShingle | Mark R. Zielinski Mark R. Zielinski Allison J. Gibbons Neuroinflammation, Sleep, and Circadian Rhythms Frontiers in Cellular and Infection Microbiology NLRP3 inflammasome cytokines electroencephalogram power vagus nerve neurovascular unit inflammation |
| title | Neuroinflammation, Sleep, and Circadian Rhythms |
| title_full | Neuroinflammation, Sleep, and Circadian Rhythms |
| title_fullStr | Neuroinflammation, Sleep, and Circadian Rhythms |
| title_full_unstemmed | Neuroinflammation, Sleep, and Circadian Rhythms |
| title_short | Neuroinflammation, Sleep, and Circadian Rhythms |
| title_sort | neuroinflammation sleep and circadian rhythms |
| topic | NLRP3 inflammasome cytokines electroencephalogram power vagus nerve neurovascular unit inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.853096/full |
| work_keys_str_mv | AT markrzielinski neuroinflammationsleepandcircadianrhythms AT markrzielinski neuroinflammationsleepandcircadianrhythms AT allisonjgibbons neuroinflammationsleepandcircadianrhythms |