Safety of chronic high-dose calcium channel blockers exposure in children with pulmonary arterial hypertension

Safety of chronic high-dose calcium channel blockers exposure in children with pulmonary arterial hypertension

BackgroundChronic calcium channel blockers (CCBs) are indicated in children with idiopathic/heritable pulmonary arterial hypertension (IPAH/HPAH) and positive response to acute vasodilator challenge. However, minimal safety data are available on the long-term high-dose exposure to CCBs in this popul...

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Bibliographic Details
Main Authors:	Yan Wu, Fu-Hua Peng, Xin Gao, Xin-Xin Yan, FengWen Zhang, Jiang-Shan Tan, Song Hu, Lu Hua
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	pediatric pulmonary arterial hypertension calcium channel blocker diltiazem high-dose toxicity
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2022.918735/full

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