RNA-binding protein IGF2BP2 enhances circ_0000745 abundancy and promotes aggressiveness and stemness of ovarian cancer cells via the microRNA-3187-3p/ERBB4/PI3K/AKT axis

RNA-binding protein IGF2BP2 enhances circ_0000745 abundancy and promotes aggressiveness and stemness of ovarian cancer cells via the microRNA-3187-3p/ERBB4/PI3K/AKT axis

Abstract Background Circular RNAs (circRNAs) are increasingly recognized as important regulators in cancer including ovarian cancer (OC). This work focuses on the effects of circ_0000745 on the OC development of and molecules involved. Methods Expression of circ_0000745 in collected OC tissues and t...

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Bibliographic Details
Main Authors: Shengtan Wang, Zaihong Li, Genhai Zhu, Lan Hong, Chunyan Hu, Kang Wang, Kaiying Cui, Chunbo Hao
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Ovarian Research
Subjects:
Ovarian cancer
IGF2BP2
circ_0000745
miR-3187-3p
ERBB4
PI3K/AKT
Online Access:https://doi.org/10.1186/s13048-021-00917-7

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