Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs
Zearalenone (ZEN) is a mycotoxin classified as an endocrine disruptor. Many endocrine disruptors are also metabolic disruptors able to modulate energy balance and inflammatory processes in a process often involving a family of protein hormones known as adipokines. The aim of our study was to elucida...
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MDPI AG
2021-11-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/13/11/790 |
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| author | Veronika Nagl Bertrand Grenier Philippe Pinton Ursula Ruczizka Maximiliane Dippel Moritz Bünger Isabelle P. Oswald Laura Soler |
| author_facet | Veronika Nagl Bertrand Grenier Philippe Pinton Ursula Ruczizka Maximiliane Dippel Moritz Bünger Isabelle P. Oswald Laura Soler |
| author_sort | Veronika Nagl |
| collection | DOAJ |
| description | Zearalenone (ZEN) is a mycotoxin classified as an endocrine disruptor. Many endocrine disruptors are also metabolic disruptors able to modulate energy balance and inflammatory processes in a process often involving a family of protein hormones known as adipokines. The aim of our study was to elucidate the role of ZEN as metabolic disruptor in pigs by investigating the changes in energy balance and adipokines levels in response to different treatment diets. To this end, weaned piglets (<i>n</i> = 10/group) were exposed to either basal feed or feed contaminated with 680 and 1620 µg/kg ZEN for 28 days. Serum samples collected at days 7 and 21 were subjected to biochemistry analysis, followed by determination of adipokine levels using a combined approach of protein array and ELISA. Results indicate that ZEN has an impact on lipid and glucose metabolism that was different depending on the dose and time of exposure. In agreement with these changes, ZEN altered circulating adipokines concentrations, inducing significant changes in adiponectin, resistin, and fetuin B. Our results suggest that ZEN may function as a natural metabolism-disrupting chemical. |
| first_indexed | 2024-03-10T05:00:38Z |
| format | Article |
| id | doaj.art-e1a7bdb31b414b17a55a5fba8e1eb649 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T05:00:38Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-e1a7bdb31b414b17a55a5fba8e1eb6492023-11-23T01:49:09ZengMDPI AGToxins2072-66512021-11-01131179010.3390/toxins13110790Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in PigsVeronika Nagl0Bertrand Grenier1Philippe Pinton2Ursula Ruczizka3Maximiliane Dippel4Moritz Bünger5Isabelle P. Oswald6Laura Soler7BIOMIN Research Center, BIOMIN Holding GmbH, Technopark 1, 3430 Tulln, AustriaBIOMIN Research Center, BIOMIN Holding GmbH, Technopark 1, 3430 Tulln, AustriaToxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP-Purpan, University of Toulouse, UPS, 31027 Toulouse, FranceUniversity Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, AustriaUniversity Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, AustriaUniversity Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, AustriaToxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP-Purpan, University of Toulouse, UPS, 31027 Toulouse, FranceToxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP-Purpan, University of Toulouse, UPS, 31027 Toulouse, FranceZearalenone (ZEN) is a mycotoxin classified as an endocrine disruptor. Many endocrine disruptors are also metabolic disruptors able to modulate energy balance and inflammatory processes in a process often involving a family of protein hormones known as adipokines. The aim of our study was to elucidate the role of ZEN as metabolic disruptor in pigs by investigating the changes in energy balance and adipokines levels in response to different treatment diets. To this end, weaned piglets (<i>n</i> = 10/group) were exposed to either basal feed or feed contaminated with 680 and 1620 µg/kg ZEN for 28 days. Serum samples collected at days 7 and 21 were subjected to biochemistry analysis, followed by determination of adipokine levels using a combined approach of protein array and ELISA. Results indicate that ZEN has an impact on lipid and glucose metabolism that was different depending on the dose and time of exposure. In agreement with these changes, ZEN altered circulating adipokines concentrations, inducing significant changes in adiponectin, resistin, and fetuin B. Our results suggest that ZEN may function as a natural metabolism-disrupting chemical.https://www.mdpi.com/2072-6651/13/11/790mycotoxinszearalenoneadipokinesmetabolismestrogen |
| spellingShingle | Veronika Nagl Bertrand Grenier Philippe Pinton Ursula Ruczizka Maximiliane Dippel Moritz Bünger Isabelle P. Oswald Laura Soler Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs Toxins mycotoxins zearalenone adipokines metabolism estrogen |
| title | Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs |
| title_full | Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs |
| title_fullStr | Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs |
| title_full_unstemmed | Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs |
| title_short | Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs |
| title_sort | exposure to zearalenone leads to metabolic disruption and changes in circulating adipokines concentrations in pigs |
| topic | mycotoxins zearalenone adipokines metabolism estrogen |
| url | https://www.mdpi.com/2072-6651/13/11/790 |
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