Clinical Utility and Alterations in Bacterial Flora in Fecal Microbiome Transplantation
Dysbiotic states of gut ecology can be altered directly by transplantation of fecal preparation from healthy donors to patients with therapeutic intent. This paper assesses this fecal microbiota transplantation (FMT) in two respects: (1) the bacterial shifts in patient microbiomes with FMT and (2) c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
University Library System, University of Pittsburgh
2015-12-01
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| Series: | International Journal of Medical Students |
| Subjects: | |
| Online Access: | http://ijms.info/IJMS/article/view/135 |
| _version_ | 1797709236690485248 |
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| author | Atman A. Dave Rachel Robson |
| author_facet | Atman A. Dave Rachel Robson |
| author_sort | Atman A. Dave |
| collection | DOAJ |
| description | Dysbiotic states of gut ecology can be altered directly by transplantation of fecal preparation from healthy donors to patients with therapeutic intent. This paper assesses this fecal microbiota transplantation (FMT) in two respects: (1) the bacterial shifts in patient microbiomes with FMT and (2) clinical outcomes and variables of FMT. The PubMed database was searched using the MeSH terms “Feces/microbiology,” “Microbiota,” and “Transplantation.” Thirteen papers found examined clinical outcomes and variables of FMT, and eight assessed metagenomic data and bacterial composition in the peri-FMT period. FMT was reported to have high cure rates in Clostridium difficile infection (CDI), generally increased levels of members of the phyla Bacteriodetes and Firmicutes, and decreased levels of members of Proteobacteria. Therapeutic FMT alters bacterial composition from a dysbiotic state pre-FMT to a healthy commensal state post-FMT in CDI patients, but further studies are necessary to understand its role in the treatment of other diseases |
| first_indexed | 2024-03-12T06:33:32Z |
| format | Article |
| id | doaj.art-e1a82d0e0f7e4141a9ab0edd2999a3f5 |
| institution | Directory Open Access Journal |
| issn | 2076-6327 |
| language | English |
| last_indexed | 2024-03-12T06:33:32Z |
| publishDate | 2015-12-01 |
| publisher | University Library System, University of Pittsburgh |
| record_format | Article |
| series | International Journal of Medical Students |
| spelling | doaj.art-e1a82d0e0f7e4141a9ab0edd2999a3f52023-09-03T01:28:30ZengUniversity Library System, University of PittsburghInternational Journal of Medical Students2076-63272015-12-013314015010.5195/ijms.2015.135135Clinical Utility and Alterations in Bacterial Flora in Fecal Microbiome TransplantationAtman A. Dave0Rachel Robson1BS, Saba University School of Medicine, USA.Pd.D., Saba University School of Medicine, USA.Dysbiotic states of gut ecology can be altered directly by transplantation of fecal preparation from healthy donors to patients with therapeutic intent. This paper assesses this fecal microbiota transplantation (FMT) in two respects: (1) the bacterial shifts in patient microbiomes with FMT and (2) clinical outcomes and variables of FMT. The PubMed database was searched using the MeSH terms “Feces/microbiology,” “Microbiota,” and “Transplantation.” Thirteen papers found examined clinical outcomes and variables of FMT, and eight assessed metagenomic data and bacterial composition in the peri-FMT period. FMT was reported to have high cure rates in Clostridium difficile infection (CDI), generally increased levels of members of the phyla Bacteriodetes and Firmicutes, and decreased levels of members of Proteobacteria. Therapeutic FMT alters bacterial composition from a dysbiotic state pre-FMT to a healthy commensal state post-FMT in CDI patients, but further studies are necessary to understand its role in the treatment of other diseaseshttp://ijms.info/IJMS/article/view/135clostridium infectionsmicrobiologyfecesfecal microbiota transplantationgastrointestinal tracthumansdrug effects[subheading]microbiotagastrointestinal microbiome |
| spellingShingle | Atman A. Dave Rachel Robson Clinical Utility and Alterations in Bacterial Flora in Fecal Microbiome Transplantation International Journal of Medical Students clostridium infections microbiology feces fecal microbiota transplantation gastrointestinal tract humans drug effects [subheading] microbiota gastrointestinal microbiome |
| title | Clinical Utility and Alterations in Bacterial Flora in Fecal Microbiome Transplantation |
| title_full | Clinical Utility and Alterations in Bacterial Flora in Fecal Microbiome Transplantation |
| title_fullStr | Clinical Utility and Alterations in Bacterial Flora in Fecal Microbiome Transplantation |
| title_full_unstemmed | Clinical Utility and Alterations in Bacterial Flora in Fecal Microbiome Transplantation |
| title_short | Clinical Utility and Alterations in Bacterial Flora in Fecal Microbiome Transplantation |
| title_sort | clinical utility and alterations in bacterial flora in fecal microbiome transplantation |
| topic | clostridium infections microbiology feces fecal microbiota transplantation gastrointestinal tract humans drug effects [subheading] microbiota gastrointestinal microbiome |
| url | http://ijms.info/IJMS/article/view/135 |
| work_keys_str_mv | AT atmanadave clinicalutilityandalterationsinbacterialflorainfecalmicrobiometransplantation AT rachelrobson clinicalutilityandalterationsinbacterialflorainfecalmicrobiometransplantation |