Cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus and its association with serum omentin and leptin
Cardiovascular autonomic neuropathy (CAN) is a major cause of morbidity and mortality in patients with diabetes as it is associated with a high risk of cardiac arrhythmias. Objectives: This prospective observational cross-sectional study was done to estimate the prevalence of CAN in patients with ty...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of Family Medicine and Primary Care |
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| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2020;volume=9;issue=6;spage=2926;epage=2930;aulast= |
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| author | R Vaishanavi Devi Velkumary Subramaniam Prashant S Adole Gandhipuram Periyasamy Senthilkumar Vadivelan Mehalingam |
| author_facet | R Vaishanavi Devi Velkumary Subramaniam Prashant S Adole Gandhipuram Periyasamy Senthilkumar Vadivelan Mehalingam |
| author_sort | R Vaishanavi Devi |
| collection | DOAJ |
| description | Cardiovascular autonomic neuropathy (CAN) is a major cause of morbidity and mortality in patients with diabetes as it is associated with a high risk of cardiac arrhythmias. Objectives: This prospective observational cross-sectional study was done to estimate the prevalence of CAN in patients with type 2 diabetes and to study its association with serum omentin and leptin levels. Methods: This study included 100 patients with type 2 diabetes mellitus attending the outpatient department of JIPMER Hospital, Pondicherry, India, from January 2017 to December 2018. CAN was assessed in all subjects using four cardiovascular autonomic function tests. Blood samples were collected and stored at - 80°C to estimate leptin and omentin levels. Comparison of leptin and omentin levels was done between diabetic patients with and without CAN. Results: CAN was present in 64% of the study subjects. Serum leptin levels were significantly higher in patients with CAN, whereas omentin levels, though elevated in those with CAN, were not statistically significant in diabetic patients without CAN. Conclusion: There is a high prevalence of CAN in patients with type 2 diabetes mellitus. Leptin levels were elevated in these patients, whereas omentin levels were not significantly different between diabetic patients with and without CAN. |
| first_indexed | 2024-12-10T10:27:18Z |
| format | Article |
| id | doaj.art-e1aa112c09c64fe396e0de74b0440a16 |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-12-10T10:27:18Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-e1aa112c09c64fe396e0de74b0440a162022-12-22T01:52:42ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632020-01-01962926293010.4103/jfmpc.jfmpc_461_20Cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus and its association with serum omentin and leptinR Vaishanavi DeviVelkumary SubramaniamPrashant S AdoleGandhipuram Periyasamy SenthilkumarVadivelan MehalingamCardiovascular autonomic neuropathy (CAN) is a major cause of morbidity and mortality in patients with diabetes as it is associated with a high risk of cardiac arrhythmias. Objectives: This prospective observational cross-sectional study was done to estimate the prevalence of CAN in patients with type 2 diabetes and to study its association with serum omentin and leptin levels. Methods: This study included 100 patients with type 2 diabetes mellitus attending the outpatient department of JIPMER Hospital, Pondicherry, India, from January 2017 to December 2018. CAN was assessed in all subjects using four cardiovascular autonomic function tests. Blood samples were collected and stored at - 80°C to estimate leptin and omentin levels. Comparison of leptin and omentin levels was done between diabetic patients with and without CAN. Results: CAN was present in 64% of the study subjects. Serum leptin levels were significantly higher in patients with CAN, whereas omentin levels, though elevated in those with CAN, were not statistically significant in diabetic patients without CAN. Conclusion: There is a high prevalence of CAN in patients with type 2 diabetes mellitus. Leptin levels were elevated in these patients, whereas omentin levels were not significantly different between diabetic patients with and without CAN.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2020;volume=9;issue=6;spage=2926;epage=2930;aulast=diabetic autonomic neuropathyleptinomentin |
| spellingShingle | R Vaishanavi Devi Velkumary Subramaniam Prashant S Adole Gandhipuram Periyasamy Senthilkumar Vadivelan Mehalingam Cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus and its association with serum omentin and leptin Journal of Family Medicine and Primary Care diabetic autonomic neuropathy leptin omentin |
| title | Cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus and its association with serum omentin and leptin |
| title_full | Cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus and its association with serum omentin and leptin |
| title_fullStr | Cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus and its association with serum omentin and leptin |
| title_full_unstemmed | Cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus and its association with serum omentin and leptin |
| title_short | Cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus and its association with serum omentin and leptin |
| title_sort | cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus and its association with serum omentin and leptin |
| topic | diabetic autonomic neuropathy leptin omentin |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2020;volume=9;issue=6;spage=2926;epage=2930;aulast= |
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