Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts
Summary: Reactive oxygen species (ROS), such as superoxide, are crucial factors involved in the stimulation of cellular aging. Mitochondria, which are important organelles responsible for various metabolic processes in cells, produce ROS. These ROS impair mitochondrial function, thereby accelerating...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223011902 |
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| author | Kayo Machihara Shoma Oki Yuka Maejima Sou Kageyama Ayumu Onda Yurino Koseki Yasuyuki Imai Takushi Namba |
| author_facet | Kayo Machihara Shoma Oki Yuka Maejima Sou Kageyama Ayumu Onda Yurino Koseki Yasuyuki Imai Takushi Namba |
| author_sort | Kayo Machihara |
| collection | DOAJ |
| description | Summary: Reactive oxygen species (ROS), such as superoxide, are crucial factors involved in the stimulation of cellular aging. Mitochondria, which are important organelles responsible for various metabolic processes in cells, produce ROS. These ROS impair mitochondrial function, thereby accelerating aging-related cellular dysfunction. Herein, we demonstrated that the Spirulina polysaccharide complex (SPC) restores mitochondrial function and collagen production by scavenging superoxide via the upregulation of superoxide dismutase 2 (SOD2) in aging fibroblasts. We observed that SOD2 expression was linked to inflammatory pathways; however, SPC did not upregulate the expression of most inflammatory cytokines produced as a result of induction of LPS in aging fibroblasts, indicating that SPC induces SOD2 without activation of inflammatory pathways. Furthermore, SPC stimulated endoplasmic reticulum (ER) protein folding by upregulating ER chaperones expression. Thus, SPC is proposed to be an antiaging material that rejuvenates aging fibroblasts by increasing their antioxidant potential via the upregulation of SOD2. |
| first_indexed | 2024-03-12T22:23:08Z |
| format | Article |
| id | doaj.art-e1ab95a03f114ebdba8b0effd42ef7c0 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T22:23:08Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-e1ab95a03f114ebdba8b0effd42ef7c02023-07-23T04:55:35ZengElsevieriScience2589-00422023-07-01267107113Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblastsKayo Machihara0Shoma Oki1Yuka Maejima2Sou Kageyama3Ayumu Onda4Yurino Koseki5Yasuyuki Imai6Takushi Namba7Research and Education Faculty, Multidisciplinary Science Cluster, Interdisciplinary Science Unit, Kochi University, Kochi 783-8505, JapanDepartment of Marine Resource Science, Faculty of Agriculture and Marine Science, Kochi University, Kochi 783-8502, JapanDepartment of Marine Resource Science, Faculty of Agriculture and Marine Science, Kochi University, Kochi 783-8502, JapanDepartment of Marine Resource Science, Faculty of Agriculture and Marine Science, Kochi University, Kochi 783-8502, JapanResearch and Education Faculty, Multidisciplinary Science Cluster, Interdisciplinary Science Unit, Kochi University, Kochi 783-8505, JapanHealth Care Technical G, Chiba Plants, DIC Corporation, Ichihara, Chiba 290-8585, JapanHealth Care Technical G, Chiba Plants, DIC Corporation, Ichihara, Chiba 290-8585, JapanResearch and Education Faculty, Multidisciplinary Science Cluster, Interdisciplinary Science Unit, Kochi University, Kochi 783-8505, Japan; Department of Marine Resource Science, Faculty of Agriculture and Marine Science, Kochi University, Kochi 783-8502, Japan; Corresponding authorSummary: Reactive oxygen species (ROS), such as superoxide, are crucial factors involved in the stimulation of cellular aging. Mitochondria, which are important organelles responsible for various metabolic processes in cells, produce ROS. These ROS impair mitochondrial function, thereby accelerating aging-related cellular dysfunction. Herein, we demonstrated that the Spirulina polysaccharide complex (SPC) restores mitochondrial function and collagen production by scavenging superoxide via the upregulation of superoxide dismutase 2 (SOD2) in aging fibroblasts. We observed that SOD2 expression was linked to inflammatory pathways; however, SPC did not upregulate the expression of most inflammatory cytokines produced as a result of induction of LPS in aging fibroblasts, indicating that SPC induces SOD2 without activation of inflammatory pathways. Furthermore, SPC stimulated endoplasmic reticulum (ER) protein folding by upregulating ER chaperones expression. Thus, SPC is proposed to be an antiaging material that rejuvenates aging fibroblasts by increasing their antioxidant potential via the upregulation of SOD2.http://www.sciencedirect.com/science/article/pii/S2589004223011902Cell biologyCellular physiologyFunctional aspects of cell biology |
| spellingShingle | Kayo Machihara Shoma Oki Yuka Maejima Sou Kageyama Ayumu Onda Yurino Koseki Yasuyuki Imai Takushi Namba Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts iScience Cell biology Cellular physiology Functional aspects of cell biology |
| title | Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts |
| title_full | Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts |
| title_fullStr | Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts |
| title_full_unstemmed | Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts |
| title_short | Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts |
| title_sort | restoration of mitochondrial function by spirulina polysaccharide via upregulated sod2 in aging fibroblasts |
| topic | Cell biology Cellular physiology Functional aspects of cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223011902 |
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