A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility
PurposeIschemic stroke (IS), a serious cerebrovascular disease, greatly affects people's health and life. Genetic factors are indispensable for the occurrence of IS. As a biomarker for IS, the MMP-9 gene is widely involved in the pathophysiological process of IS. This study attempts to find out...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1178642/full |
| _version_ | 1797786949526749184 |
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| author | Hanming Ge Xiaojuan Ma Jiachen Wang Xiaobo Zhang Yu Zhang Qi Zhang Wu Li Jie Liu Jinwei Duan Wenzhen Shi Ye Tian |
| author_facet | Hanming Ge Xiaojuan Ma Jiachen Wang Xiaobo Zhang Yu Zhang Qi Zhang Wu Li Jie Liu Jinwei Duan Wenzhen Shi Ye Tian |
| author_sort | Hanming Ge |
| collection | DOAJ |
| description | PurposeIschemic stroke (IS), a serious cerebrovascular disease, greatly affects people's health and life. Genetic factors are indispensable for the occurrence of IS. As a biomarker for IS, the MMP-9 gene is widely involved in the pathophysiological process of IS. This study attempts to find out the relationship between MMP-9 polymorphisms and IS susceptibility.MethodsA total of 700 IS patients and 700 healthy controls were recruited. The single nucleotide polymorphism (SNP) markers of the MMP-9 gene were genotyped by the MassARRAY analyzer. Multifactor dimensionality reduction (MDR) was applied to generate SNP–SNP interaction. Furthermore, the relationship between genetic variations (allele and genotype) of the MMP-9 gene and IS susceptibility was analyzed by calculating odds ratios (ORs) and 95% confidence intervals (CIs).ResultsOur results demonstrated that rs2250889 could significantly increase the susceptibility to IS in the codominant, dominant, overdominant, and log-additive models (p < 0.05). Further stratification analysis showed that compared with the control group, rs2250889 was associated with IS risk in different case groups (age, female, smoking, and non-drinking) (p < 0.05). Based on MDR analysis, rs2250889 was the best model for predicting IS risk (cross-validation consistency: 10/10, OR = 1.56 (1.26–1.94), p < 0.001).ConclusionOur study preliminarily confirmed that SNP rs2250889 was significantly associated with susceptibility to IS. |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-13T01:15:05Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-e1b0e5c5d4f5450fbc50dcbd912753182023-07-05T12:07:47ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-07-011410.3389/fneur.2023.11786421178642A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibilityHanming Ge0Xiaojuan Ma1Jiachen Wang2Xiaobo Zhang3Yu Zhang4Qi Zhang5Wu Li6Jie Liu7Jinwei Duan8Wenzhen Shi9Ye Tian10Department of Neurology, Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, Shaanxi, ChinaMedical Research Center, Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, Shaanxi, ChinaThe College of Life Sciences, Northwest University, Xi'an, Shaanxi, ChinaThe College of Life Sciences, Northwest University, Xi'an, Shaanxi, ChinaThe College of Life Sciences, Northwest University, Xi'an, Shaanxi, ChinaThe College of Life Sciences, Northwest University, Xi'an, Shaanxi, ChinaMedical Research Center, Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, Shaanxi, ChinaMedical Research Center, Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, Shaanxi, ChinaMedical Research Center, Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, Shaanxi, ChinaMedical Research Center, Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, Shaanxi, ChinaDepartment of Neurology, Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, Shaanxi, ChinaPurposeIschemic stroke (IS), a serious cerebrovascular disease, greatly affects people's health and life. Genetic factors are indispensable for the occurrence of IS. As a biomarker for IS, the MMP-9 gene is widely involved in the pathophysiological process of IS. This study attempts to find out the relationship between MMP-9 polymorphisms and IS susceptibility.MethodsA total of 700 IS patients and 700 healthy controls were recruited. The single nucleotide polymorphism (SNP) markers of the MMP-9 gene were genotyped by the MassARRAY analyzer. Multifactor dimensionality reduction (MDR) was applied to generate SNP–SNP interaction. Furthermore, the relationship between genetic variations (allele and genotype) of the MMP-9 gene and IS susceptibility was analyzed by calculating odds ratios (ORs) and 95% confidence intervals (CIs).ResultsOur results demonstrated that rs2250889 could significantly increase the susceptibility to IS in the codominant, dominant, overdominant, and log-additive models (p < 0.05). Further stratification analysis showed that compared with the control group, rs2250889 was associated with IS risk in different case groups (age, female, smoking, and non-drinking) (p < 0.05). Based on MDR analysis, rs2250889 was the best model for predicting IS risk (cross-validation consistency: 10/10, OR = 1.56 (1.26–1.94), p < 0.001).ConclusionOur study preliminarily confirmed that SNP rs2250889 was significantly associated with susceptibility to IS.https://www.frontiersin.org/articles/10.3389/fneur.2023.1178642/fullMMP-9SNPsusceptibilitycase-control studyischemic stroke |
| spellingShingle | Hanming Ge Xiaojuan Ma Jiachen Wang Xiaobo Zhang Yu Zhang Qi Zhang Wu Li Jie Liu Jinwei Duan Wenzhen Shi Ye Tian A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility Frontiers in Neurology MMP-9 SNP susceptibility case-control study ischemic stroke |
| title | A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility |
| title_full | A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility |
| title_fullStr | A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility |
| title_full_unstemmed | A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility |
| title_short | A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility |
| title_sort | potential relationship between mmp 9 rs2250889 and ischemic stroke susceptibility |
| topic | MMP-9 SNP susceptibility case-control study ischemic stroke |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1178642/full |
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