Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines
Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6–12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB23...
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| Format: | Article |
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MDPI AG
2014-11-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/11/18993 |
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| author | Ivan Montenegro Giacomo Tomasoni Claudia Bosio Natalia Quiñones Alejandro Madrid Hector Carrasco Andres Olea Rolando Martinez Mauricio Cuellar Joan Villena |
| author_facet | Ivan Montenegro Giacomo Tomasoni Claudia Bosio Natalia Quiñones Alejandro Madrid Hector Carrasco Andres Olea Rolando Martinez Mauricio Cuellar Joan Villena |
| author_sort | Ivan Montenegro |
| collection | DOAJ |
| description | Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6–12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5–100 µM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells. |
| first_indexed | 2024-12-11T07:41:15Z |
| format | Article |
| id | doaj.art-e1b598cd36b14f0790bc4fceb7b65e51 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T07:41:15Z |
| publishDate | 2014-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e1b598cd36b14f0790bc4fceb7b65e512022-12-22T01:15:34ZengMDPI AGMolecules1420-30492014-11-011911189931900610.3390/molecules191118993molecules191118993Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell LinesIvan Montenegro0Giacomo Tomasoni1Claudia Bosio2Natalia Quiñones3Alejandro Madrid4Hector Carrasco5Andres Olea6Rolando Martinez7Mauricio Cuellar8Joan Villena9Facultad de Farmacia, Escuela de Química y Farmacia, Universidad de Valparaíso, Av. Gran Bretaña N° 1093, Valparaíso 234000, ChileDepartamento de Química, Facultad de Ciencias Exactas, Universidad Andrés Bello, Quillota 910, Viña del Mar 2520000, ChileDepartamento de Química, Facultad de Ciencias Exactas, Universidad Andrés Bello, Quillota 910, Viña del Mar 2520000, ChileFacultad de Farmacia, Escuela de Química y Farmacia, Universidad de Valparaíso, Av. Gran Bretaña N° 1093, Valparaíso 234000, ChileDepartamento de Química, Universidad Técnica Federico Santa María, Av. España N° 1680, Valparaíso 2340000, ChileFacultad de Ciencias de la Salud, Universidad Autónoma de Chile, Carlos Antúnez 1920, Providencia, Santiago 7500000, ChileFacultad de Ciencias de la Salud, Universidad Autónoma de Chile, Carlos Antúnez 1920, Providencia, Santiago 7500000, ChileDepartamento de Química, Facultad de Ciencias Exactas, Universidad Andrés Bello, Quillota 910, Viña del Mar 2520000, ChileFacultad de Farmacia, Escuela de Química y Farmacia, Universidad de Valparaíso, Av. Gran Bretaña N° 1093, Valparaíso 234000, ChileCentro de Investigaciones Biomédicas (CIB), Escuela de Medicina, Universidad de Valparaíso, Av. Hontaneda N° 2664, Valparaíso 234000, ChileTwelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6–12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5–100 µM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells.http://www.mdpi.com/1420-3049/19/11/18993cytotoxic activitycancer cell linesapoptosismitochondrial membrane permeabilitycaspasa-3 activitynordrimanesdrimanessesquiterpenes |
| spellingShingle | Ivan Montenegro Giacomo Tomasoni Claudia Bosio Natalia Quiñones Alejandro Madrid Hector Carrasco Andres Olea Rolando Martinez Mauricio Cuellar Joan Villena Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines Molecules cytotoxic activity cancer cell lines apoptosis mitochondrial membrane permeability caspasa-3 activity nordrimanes drimanes sesquiterpenes |
| title | Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines |
| title_full | Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines |
| title_fullStr | Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines |
| title_full_unstemmed | Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines |
| title_short | Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines |
| title_sort | study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines |
| topic | cytotoxic activity cancer cell lines apoptosis mitochondrial membrane permeability caspasa-3 activity nordrimanes drimanes sesquiterpenes |
| url | http://www.mdpi.com/1420-3049/19/11/18993 |
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