Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines

Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines

Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6–12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB23...

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Bibliographic Details
Main Authors:	Ivan Montenegro, Giacomo Tomasoni, Claudia Bosio, Natalia Quiñones, Alejandro Madrid, Hector Carrasco, Andres Olea, Rolando Martinez, Mauricio Cuellar, Joan Villena
Format:	Article
Language:	English
Published:	MDPI AG 2014-11-01
Series:	Molecules
Subjects:	cytotoxic activity cancer cell lines apoptosis mitochondrial membrane permeability caspasa-3 activity nordrimanes drimanes sesquiterpenes
Online Access:	http://www.mdpi.com/1420-3049/19/11/18993

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