Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment
Abstract Background Growth hormone (GH) has been linked to cardiovascular disease but the exact mechanism of this association is still unclear. We here test if the fasting levels of GH are cross-sectionally associated with carotid intima media thickness (IMT) and whether treatment with fluvastatin a...
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| Format: | Article |
| Language: | English |
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BMC
2017-05-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12872-017-0563-9 |
| _version_ | 1811305795847979008 |
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| author | Erik Hallengren Peter Almgren Maria Rosvall Gerd Östling Margaretha Persson Andreas Bergmann Joachim Struck Gunnar Engström Bo Hedblad Olle Melander |
| author_facet | Erik Hallengren Peter Almgren Maria Rosvall Gerd Östling Margaretha Persson Andreas Bergmann Joachim Struck Gunnar Engström Bo Hedblad Olle Melander |
| author_sort | Erik Hallengren |
| collection | DOAJ |
| description | Abstract Background Growth hormone (GH) has been linked to cardiovascular disease but the exact mechanism of this association is still unclear. We here test if the fasting levels of GH are cross-sectionally associated with carotid intima media thickness (IMT) and whether treatment with fluvastatin affects the fasting level of GH. Methods We examined the association between GH and IMT in 4425 individuals (aged 46–68 years) included in the baseline examination (1991–1994) of the Malmö Diet and Cancer cardiovascular cohort (MDC-CC). From that cohort we then studied 472 individuals (aged 50-70 years) who also participated (1994–1999) in the β-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS), a randomized, double blind, placebo-controlled, single-center clinical trial. Using multivariate linear regression models we related the change in GH-levels at 12 months compared with baseline to treatment with 40 mg fluvastatin once daily. Results In MDC-CC fasting values of GH exhibited a positive cross-sectional relation to the IMT at the carotid bulb independent of traditional cardiovascular risk factors (p = 0.002). In a gender-stratified analysis the correlation were significant for males (p = 0.005), but not for females (p = 0.09). Treatment with fluvastatin was associated with a minor reduction in the fasting levels of hs-GH in males (p = 0.05) and a minor rise in the same levels among females (p = 0.05). Conclusions We here demonstrate that higher fasting levels of GH are associated with thicker IMT in the carotid bulb in males. Treatment with fluvastatin for 12 months only had a minor, and probably not clinically relevant, effect on the fasting levels of hs-GH. |
| first_indexed | 2024-04-13T08:32:46Z |
| format | Article |
| id | doaj.art-e1b7a2f2aef04aaaa8310e45ab9229a9 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-13T08:32:46Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-e1b7a2f2aef04aaaa8310e45ab9229a92022-12-22T02:54:13ZengBMCBMC Cardiovascular Disorders1471-22612017-05-0117111010.1186/s12872-017-0563-9Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatmentErik Hallengren0Peter Almgren1Maria Rosvall2Gerd Östling3Margaretha Persson4Andreas Bergmann5Joachim Struck6Gunnar Engström7Bo Hedblad8Olle Melander9Department of Clinical Sciences, Lund UniversityDepartment of Clinical Sciences, Lund UniversityDepartment of Clinical Sciences, Lund UniversityDepartment of Clinical Sciences, Lund UniversityDepartment of Clinical Sciences, Lund UniversitySphingoTec GmbHSphingoTec GmbHDepartment of Clinical Sciences, Lund UniversityDepartment of Clinical Sciences, Lund UniversityDepartment of Clinical Sciences, Lund UniversityAbstract Background Growth hormone (GH) has been linked to cardiovascular disease but the exact mechanism of this association is still unclear. We here test if the fasting levels of GH are cross-sectionally associated with carotid intima media thickness (IMT) and whether treatment with fluvastatin affects the fasting level of GH. Methods We examined the association between GH and IMT in 4425 individuals (aged 46–68 years) included in the baseline examination (1991–1994) of the Malmö Diet and Cancer cardiovascular cohort (MDC-CC). From that cohort we then studied 472 individuals (aged 50-70 years) who also participated (1994–1999) in the β-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS), a randomized, double blind, placebo-controlled, single-center clinical trial. Using multivariate linear regression models we related the change in GH-levels at 12 months compared with baseline to treatment with 40 mg fluvastatin once daily. Results In MDC-CC fasting values of GH exhibited a positive cross-sectional relation to the IMT at the carotid bulb independent of traditional cardiovascular risk factors (p = 0.002). In a gender-stratified analysis the correlation were significant for males (p = 0.005), but not for females (p = 0.09). Treatment with fluvastatin was associated with a minor reduction in the fasting levels of hs-GH in males (p = 0.05) and a minor rise in the same levels among females (p = 0.05). Conclusions We here demonstrate that higher fasting levels of GH are associated with thicker IMT in the carotid bulb in males. Treatment with fluvastatin for 12 months only had a minor, and probably not clinically relevant, effect on the fasting levels of hs-GH.http://link.springer.com/article/10.1186/s12872-017-0563-9Growth hormoneStatinsImtLipidsCardiovascular disease |
| spellingShingle | Erik Hallengren Peter Almgren Maria Rosvall Gerd Östling Margaretha Persson Andreas Bergmann Joachim Struck Gunnar Engström Bo Hedblad Olle Melander Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment BMC Cardiovascular Disorders Growth hormone Statins Imt Lipids Cardiovascular disease |
| title | Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment |
| title_full | Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment |
| title_fullStr | Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment |
| title_full_unstemmed | Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment |
| title_short | Fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment |
| title_sort | fasting levels of growth hormone are associated with carotid intima media thickness but are not affected by fluvastatin treatment |
| topic | Growth hormone Statins Imt Lipids Cardiovascular disease |
| url | http://link.springer.com/article/10.1186/s12872-017-0563-9 |
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