Hypoxia-induced factor-1α and markers of inflammation in patients with ischemic stroke
Ischemic stroke (IS) occurs as a result of local disturbance of hemocirculation and hypoxia in the brain tissue. Hypoxia-inducible factor-1α (HIF-1α), which is involved in the regulation of tissue oxygen levels, plays an important role in the pathophysiology of stroke, including neuronal survival, n...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2023-06-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/2740 |
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| author | L. P. Pivovarova I. A. Voznyuk I. V. Osipova O. B. Ariskina E. A. Gogoleva M. V. Prokhorova N. G. Karpova |
| author_facet | L. P. Pivovarova I. A. Voznyuk I. V. Osipova O. B. Ariskina E. A. Gogoleva M. V. Prokhorova N. G. Karpova |
| author_sort | L. P. Pivovarova |
| collection | DOAJ |
| description | Ischemic stroke (IS) occurs as a result of local disturbance of hemocirculation and hypoxia in the brain tissue. Hypoxia-inducible factor-1α (HIF-1α), which is involved in the regulation of tissue oxygen levels, plays an important role in the pathophysiology of stroke, including neuronal survival, neuroinflammation, angiogenesis, glucose metabolism, blood-brain barrier permeability, and is important in IS outcomes. The purpose of the study was to determine the relationship between blood levels of HIF-1α and the degree of neurological deficit in the acute period of IS and the outcome of the disease. We examined 58 people with IS aged 73 (67-81) years. Patients were divided into two groups – discharged and dead. The severity of stroke (NIHSS), neurological deficit, comorbidity index, blood levels of HIF-1α, p53 protein, interleukin-6, cystatin C, CRP, creatinine, hematological parameters were determined at admission, on days 3 and 10 of the disease. At admission the blood levels of HIF-1α was lower than in the comparison group and remained reduced until the 10th day. On day 10 the association of HIF-1α with neurological deficit, comorbidity index and disease outcome was determined. We observed a feedback of HIF-1α with the content of erythrocytes, hemoglobin and hematocrit, which can be regarded as a reflection of the hemic component of mixed hypoxia. In dead patients, an increased blood level of cystatin C was detected, which was associated with HIF-1α concentrations. In all periods of observation of IS, a correlation between cystatin C and creatinine and CRP levels was noted. These results may indicate dysfunction of endotheliocytes, inflammation associated with hypoxia in IS. The prognostic significance of the blood level of HIF-1α on the 10th day for the outcome of IS was AUC = 0.900. Blood levels of HIF-1α in the acute period was associated with the severity of IS and the outcome of the disease. |
| first_indexed | 2024-03-08T05:47:08Z |
| format | Article |
| id | doaj.art-e1b8518bcb524c55ae370415b8342917 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:49:20Z |
| publishDate | 2023-06-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-e1b8518bcb524c55ae370415b83429172024-04-22T13:07:50ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2023-06-0125499199610.15789/1563-0625-HIF-27401728Hypoxia-induced factor-1α and markers of inflammation in patients with ischemic strokeL. P. Pivovarova0I. A. Voznyuk1I. V. Osipova2O. B. Ariskina3E. A. Gogoleva4M. V. Prokhorova5N. G. Karpova6I. Dzhanelidze Research Institute of Emergency MedicineFirst St. Petersburg State I. Pavlov Medical UniversityI. Dzhanelidze Research Institute of Emergency MedicineI. Dzhanelidze Research Institute of Emergency MedicineI. Dzhanelidze Research Institute of Emergency MedicineI. Dzhanelidze Research Institute of Emergency MedicineI. Dzhanelidze Research Institute of Emergency MedicineIschemic stroke (IS) occurs as a result of local disturbance of hemocirculation and hypoxia in the brain tissue. Hypoxia-inducible factor-1α (HIF-1α), which is involved in the regulation of tissue oxygen levels, plays an important role in the pathophysiology of stroke, including neuronal survival, neuroinflammation, angiogenesis, glucose metabolism, blood-brain barrier permeability, and is important in IS outcomes. The purpose of the study was to determine the relationship between blood levels of HIF-1α and the degree of neurological deficit in the acute period of IS and the outcome of the disease. We examined 58 people with IS aged 73 (67-81) years. Patients were divided into two groups – discharged and dead. The severity of stroke (NIHSS), neurological deficit, comorbidity index, blood levels of HIF-1α, p53 protein, interleukin-6, cystatin C, CRP, creatinine, hematological parameters were determined at admission, on days 3 and 10 of the disease. At admission the blood levels of HIF-1α was lower than in the comparison group and remained reduced until the 10th day. On day 10 the association of HIF-1α with neurological deficit, comorbidity index and disease outcome was determined. We observed a feedback of HIF-1α with the content of erythrocytes, hemoglobin and hematocrit, which can be regarded as a reflection of the hemic component of mixed hypoxia. In dead patients, an increased blood level of cystatin C was detected, which was associated with HIF-1α concentrations. In all periods of observation of IS, a correlation between cystatin C and creatinine and CRP levels was noted. These results may indicate dysfunction of endotheliocytes, inflammation associated with hypoxia in IS. The prognostic significance of the blood level of HIF-1α on the 10th day for the outcome of IS was AUC = 0.900. Blood levels of HIF-1α in the acute period was associated with the severity of IS and the outcome of the disease.https://www.mimmun.ru/mimmun/article/view/2740hypoxia-induced factor-1αapoptosismarkers of inflammationcystatin cischemic strokeoutcome |
| spellingShingle | L. P. Pivovarova I. A. Voznyuk I. V. Osipova O. B. Ariskina E. A. Gogoleva M. V. Prokhorova N. G. Karpova Hypoxia-induced factor-1α and markers of inflammation in patients with ischemic stroke Медицинская иммунология hypoxia-induced factor-1α apoptosis markers of inflammation cystatin c ischemic stroke outcome |
| title | Hypoxia-induced factor-1α and markers of inflammation in patients with ischemic stroke |
| title_full | Hypoxia-induced factor-1α and markers of inflammation in patients with ischemic stroke |
| title_fullStr | Hypoxia-induced factor-1α and markers of inflammation in patients with ischemic stroke |
| title_full_unstemmed | Hypoxia-induced factor-1α and markers of inflammation in patients with ischemic stroke |
| title_short | Hypoxia-induced factor-1α and markers of inflammation in patients with ischemic stroke |
| title_sort | hypoxia induced factor 1α and markers of inflammation in patients with ischemic stroke |
| topic | hypoxia-induced factor-1α apoptosis markers of inflammation cystatin c ischemic stroke outcome |
| url | https://www.mimmun.ru/mimmun/article/view/2740 |
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