Effect of coating thickness of iron oxide nanoparticles on their relaxivity in the MRI
Objective(s):Iron oxide nanoparticles have found prevalent applications in various fields including drug delivery, cell separation and as contrast agents. Super paramagnetic iron oxide (SPIO) nanoparticles allow researchers and clinicians to enhance the tissue contrast of an area of interest by incr...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2016-02-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | http://ijbms.mums.ac.ir/article_6540_42ab0689da4b798d9a9c6fbe4044d9bb.pdf |
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| author | Farzaneh Hajesmaeelzadeh Saeed Shanehsazzadeh Cordula Grüttner Fariba Johari Daha Mohammad Ali Oghabian |
| author_facet | Farzaneh Hajesmaeelzadeh Saeed Shanehsazzadeh Cordula Grüttner Fariba Johari Daha Mohammad Ali Oghabian |
| author_sort | Farzaneh Hajesmaeelzadeh |
| collection | DOAJ |
| description | Objective(s):Iron oxide nanoparticles have found prevalent applications in various fields including drug delivery, cell separation and as contrast agents. Super paramagnetic iron oxide (SPIO) nanoparticles allow researchers and clinicians to enhance the tissue contrast of an area of interest by increasing the relaxation rate of water. In this study, we evaluate the dependency of hydrodynamic size of iron oxide nanoparticles coated with Polyethylene glycol (PEG) on their relativities with 3 Tesla clinical MRI. Materials and Methods: We used three groups of nanoparticles with nominal sizes 20, 50 and 100 nm with a core size of 8.86 nm, 8.69 nm and 10.4 nm that they were covered with PEG 300 and 600 Da. A clinical magnetic resonance scanner determines the T1 and T2 relaxation times for various concentrations of PEG-coated nanoparticles. Results: The size measurement by photon correlation spectroscopy showed the hydrodynamic sizes of MNPs with nominal 20, 50 and 100 nm with 70, 82 and 116 nm for particles with PEG 600 coating and 74, 93 and 100 nm for particles with PEG 300 coating, respectively. We foud that the relaxivity decreased with increasing overall particle size (via coating thickness). Magnetic resonance imaging showed that by increasing the size of the nanoparticles, r2/r1 increases linearly. Conclusion: According to the data obtained from this study it can be concluded that increments in coating thickness have more influence on relaxivities compared to the changes in core size of magnetic nanoparticles. |
| first_indexed | 2024-12-14T14:27:05Z |
| format | Article |
| id | doaj.art-e1b8e7e9e56745efbf3b51b738e7000e |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-14T14:27:05Z |
| publishDate | 2016-02-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-e1b8e7e9e56745efbf3b51b738e7000e2022-12-21T22:57:56ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742016-02-011921661716540Effect of coating thickness of iron oxide nanoparticles on their relaxivity in the MRIFarzaneh Hajesmaeelzadeh0Saeed Shanehsazzadeh1Cordula Grüttner2Fariba Johari Daha3Mohammad Ali Oghabian4Biomolecular Imaging Analysis Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran|Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Science, Tehran, IranRadiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, IranMicromod Partikeltechnologie GmbH, Friedrich-Barnewitz-Str. 4, D-18119 Rostock, GermanyRadiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, IranBiomolecular Imaging Analysis Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran|Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Science, Tehran, IranObjective(s):Iron oxide nanoparticles have found prevalent applications in various fields including drug delivery, cell separation and as contrast agents. Super paramagnetic iron oxide (SPIO) nanoparticles allow researchers and clinicians to enhance the tissue contrast of an area of interest by increasing the relaxation rate of water. In this study, we evaluate the dependency of hydrodynamic size of iron oxide nanoparticles coated with Polyethylene glycol (PEG) on their relativities with 3 Tesla clinical MRI. Materials and Methods: We used three groups of nanoparticles with nominal sizes 20, 50 and 100 nm with a core size of 8.86 nm, 8.69 nm and 10.4 nm that they were covered with PEG 300 and 600 Da. A clinical magnetic resonance scanner determines the T1 and T2 relaxation times for various concentrations of PEG-coated nanoparticles. Results: The size measurement by photon correlation spectroscopy showed the hydrodynamic sizes of MNPs with nominal 20, 50 and 100 nm with 70, 82 and 116 nm for particles with PEG 600 coating and 74, 93 and 100 nm for particles with PEG 300 coating, respectively. We foud that the relaxivity decreased with increasing overall particle size (via coating thickness). Magnetic resonance imaging showed that by increasing the size of the nanoparticles, r2/r1 increases linearly. Conclusion: According to the data obtained from this study it can be concluded that increments in coating thickness have more influence on relaxivities compared to the changes in core size of magnetic nanoparticles.http://ijbms.mums.ac.ir/article_6540_42ab0689da4b798d9a9c6fbe4044d9bb.pdfCoating thickness Hydrodynamic sizeNanoparticlesRelaxivity |
| spellingShingle | Farzaneh Hajesmaeelzadeh Saeed Shanehsazzadeh Cordula Grüttner Fariba Johari Daha Mohammad Ali Oghabian Effect of coating thickness of iron oxide nanoparticles on their relaxivity in the MRI Iranian Journal of Basic Medical Sciences Coating thickness Hydrodynamic size Nanoparticles Relaxivity |
| title | Effect of coating thickness of iron oxide nanoparticles on their relaxivity in the MRI |
| title_full | Effect of coating thickness of iron oxide nanoparticles on their relaxivity in the MRI |
| title_fullStr | Effect of coating thickness of iron oxide nanoparticles on their relaxivity in the MRI |
| title_full_unstemmed | Effect of coating thickness of iron oxide nanoparticles on their relaxivity in the MRI |
| title_short | Effect of coating thickness of iron oxide nanoparticles on their relaxivity in the MRI |
| title_sort | effect of coating thickness of iron oxide nanoparticles on their relaxivity in the mri |
| topic | Coating thickness Hydrodynamic size Nanoparticles Relaxivity |
| url | http://ijbms.mums.ac.ir/article_6540_42ab0689da4b798d9a9c6fbe4044d9bb.pdf |
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