Prenatal Cadmium Exposure and Maternal Sex Steroid Hormone Concentrations across Pregnancy
Cadmium exposure has been associated with adverse perinatal outcomes. One possible mechanism is endocrine disruption. Studies of non-pregnant adults suggest that cadmium impacts androgen production; here, we examined these associations during pregnancy. Participants in the Understanding Pregnancy Si...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/11/7/589 |
| _version_ | 1797587413103542272 |
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| author | Zorimar Rivera-Núñez Megan Hansel Camila Capurro Danielle Kozlosky Christina Wang Cathleen L. Doherty Brian Buckley Pamela Ohman-Strickland Richard K. Miller Thomas G. O’Connor Lauren M. Aleksunes Emily S. Barrett |
| author_facet | Zorimar Rivera-Núñez Megan Hansel Camila Capurro Danielle Kozlosky Christina Wang Cathleen L. Doherty Brian Buckley Pamela Ohman-Strickland Richard K. Miller Thomas G. O’Connor Lauren M. Aleksunes Emily S. Barrett |
| author_sort | Zorimar Rivera-Núñez |
| collection | DOAJ |
| description | Cadmium exposure has been associated with adverse perinatal outcomes. One possible mechanism is endocrine disruption. Studies of non-pregnant adults suggest that cadmium impacts androgen production; here, we examined these associations during pregnancy. Participants in the Understanding Pregnancy Signals and Infant Development (UPSIDE) cohort provided biospecimens and questionnaire data in each trimester (n = 272). We quantified urinary cadmium, serum total testosterone (TT), estrone, estradiol, and estriol and serum free testosterone (fT). In adjusted longitudinal models, we examined sex steroid concentrations across pregnancy in relation to specific gravity-adjusted, ln-transformed cadmium concentrations. Additionally, we examined trimester-specific associations and stratified models by fetal sex. Results are presented as percent change (%∆) in hormone concentrations. In longitudinal models, higher cadmium concentrations were associated with lower fT across pregnancy (%∆ = −5.19, 95%CI: −8.33, −1.93), with no differences in other hormones observed. In trimester-specific models, higher cadmium concentrations were associated with lower TT in trimester 2 (%∆ = −15.26, 95%CI: −25.15, −4.06) and lower fT in trimester 3 (%∆ = −14.35, 95%CI: −19.75, −8.59). Associations with TT were stronger in pregnancies carrying female fetuses. Maternal cadmium exposure may be associated with reduced testosterone in pregnancy. Additional work is necessary to understand how alterations in gestational testosterone activity may impact pregnancy and child health. |
| first_indexed | 2024-03-11T00:36:38Z |
| format | Article |
| id | doaj.art-e1be5ec65e22499fa16865694e4f8927 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-11T00:36:38Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-e1be5ec65e22499fa16865694e4f89272023-11-18T21:37:00ZengMDPI AGToxics2305-63042023-07-0111758910.3390/toxics11070589Prenatal Cadmium Exposure and Maternal Sex Steroid Hormone Concentrations across PregnancyZorimar Rivera-Núñez0Megan Hansel1Camila Capurro2Danielle Kozlosky3Christina Wang4Cathleen L. Doherty5Brian Buckley6Pamela Ohman-Strickland7Richard K. Miller8Thomas G. O’Connor9Lauren M. Aleksunes10Emily S. Barrett11Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USADepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USADepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USAEnvironmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USAClinical and Translational Science Institute, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USAEnvironmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USAEnvironmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USADepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USADepartment of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY 14620, USADepartment of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY 14620, USAEnvironmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USADepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USACadmium exposure has been associated with adverse perinatal outcomes. One possible mechanism is endocrine disruption. Studies of non-pregnant adults suggest that cadmium impacts androgen production; here, we examined these associations during pregnancy. Participants in the Understanding Pregnancy Signals and Infant Development (UPSIDE) cohort provided biospecimens and questionnaire data in each trimester (n = 272). We quantified urinary cadmium, serum total testosterone (TT), estrone, estradiol, and estriol and serum free testosterone (fT). In adjusted longitudinal models, we examined sex steroid concentrations across pregnancy in relation to specific gravity-adjusted, ln-transformed cadmium concentrations. Additionally, we examined trimester-specific associations and stratified models by fetal sex. Results are presented as percent change (%∆) in hormone concentrations. In longitudinal models, higher cadmium concentrations were associated with lower fT across pregnancy (%∆ = −5.19, 95%CI: −8.33, −1.93), with no differences in other hormones observed. In trimester-specific models, higher cadmium concentrations were associated with lower TT in trimester 2 (%∆ = −15.26, 95%CI: −25.15, −4.06) and lower fT in trimester 3 (%∆ = −14.35, 95%CI: −19.75, −8.59). Associations with TT were stronger in pregnancies carrying female fetuses. Maternal cadmium exposure may be associated with reduced testosterone in pregnancy. Additional work is necessary to understand how alterations in gestational testosterone activity may impact pregnancy and child health.https://www.mdpi.com/2305-6304/11/7/589cadmiumsex steroid hormonespregnancyandrogenstestosterone |
| spellingShingle | Zorimar Rivera-Núñez Megan Hansel Camila Capurro Danielle Kozlosky Christina Wang Cathleen L. Doherty Brian Buckley Pamela Ohman-Strickland Richard K. Miller Thomas G. O’Connor Lauren M. Aleksunes Emily S. Barrett Prenatal Cadmium Exposure and Maternal Sex Steroid Hormone Concentrations across Pregnancy Toxics cadmium sex steroid hormones pregnancy androgens testosterone |
| title | Prenatal Cadmium Exposure and Maternal Sex Steroid Hormone Concentrations across Pregnancy |
| title_full | Prenatal Cadmium Exposure and Maternal Sex Steroid Hormone Concentrations across Pregnancy |
| title_fullStr | Prenatal Cadmium Exposure and Maternal Sex Steroid Hormone Concentrations across Pregnancy |
| title_full_unstemmed | Prenatal Cadmium Exposure and Maternal Sex Steroid Hormone Concentrations across Pregnancy |
| title_short | Prenatal Cadmium Exposure and Maternal Sex Steroid Hormone Concentrations across Pregnancy |
| title_sort | prenatal cadmium exposure and maternal sex steroid hormone concentrations across pregnancy |
| topic | cadmium sex steroid hormones pregnancy androgens testosterone |
| url | https://www.mdpi.com/2305-6304/11/7/589 |
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