Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity.
Aristolochia manshuriensis Kom (AMK) is a member of the Aristolochiaceae family and is a well-known cause of aristolochic acid (AA) nephropathy. In this study, we investigated the potential of omeprazole (OM) to alleviate AMK-induced nephrotoxicity. We found that OM reduced mouse mortality caused by...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5055352?pdf=render |
| _version_ | 1818552570076987392 |
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| author | Lianmei Wang Hongbing Zhang Chunying Li Yan Yi Jing Liu Yong Zhao Jingzhuo Tian Yushi Zhang Xiaolu Wei Yue Gao Aihua Liang |
| author_facet | Lianmei Wang Hongbing Zhang Chunying Li Yan Yi Jing Liu Yong Zhao Jingzhuo Tian Yushi Zhang Xiaolu Wei Yue Gao Aihua Liang |
| author_sort | Lianmei Wang |
| collection | DOAJ |
| description | Aristolochia manshuriensis Kom (AMK) is a member of the Aristolochiaceae family and is a well-known cause of aristolochic acid (AA) nephropathy. In this study, we investigated the potential of omeprazole (OM) to alleviate AMK-induced nephrotoxicity. We found that OM reduced mouse mortality caused by AMK and attenuated AMK-induced acute nephrotoxicity in rats. OM enhanced hepatic Cyp 1a1/2 and renal Cyp 1a1 expression in rats, as well as CYP 1A1 expression in human renal tubular epithelial cells (HKCs). HKCs with ectopic CYP 1A1 expression were more tolerant to AA than the control cells. Therefore, OM may alleviate AMK-mediated acute nephrotoxicity through induction of CYP 1A1. We suggest that the coadministration of OM might be beneficial for reducing of AA-induced nephrotoxicity. |
| first_indexed | 2024-12-12T09:14:54Z |
| format | Article |
| id | doaj.art-e1be7f8dc5c64d73ae1b8b99f282efe8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T09:14:54Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e1be7f8dc5c64d73ae1b8b99f282efe82022-12-22T00:29:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011110e016421510.1371/journal.pone.0164215Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity.Lianmei WangHongbing ZhangChunying LiYan YiJing LiuYong ZhaoJingzhuo TianYushi ZhangXiaolu WeiYue GaoAihua LiangAristolochia manshuriensis Kom (AMK) is a member of the Aristolochiaceae family and is a well-known cause of aristolochic acid (AA) nephropathy. In this study, we investigated the potential of omeprazole (OM) to alleviate AMK-induced nephrotoxicity. We found that OM reduced mouse mortality caused by AMK and attenuated AMK-induced acute nephrotoxicity in rats. OM enhanced hepatic Cyp 1a1/2 and renal Cyp 1a1 expression in rats, as well as CYP 1A1 expression in human renal tubular epithelial cells (HKCs). HKCs with ectopic CYP 1A1 expression were more tolerant to AA than the control cells. Therefore, OM may alleviate AMK-mediated acute nephrotoxicity through induction of CYP 1A1. We suggest that the coadministration of OM might be beneficial for reducing of AA-induced nephrotoxicity.http://europepmc.org/articles/PMC5055352?pdf=render |
| spellingShingle | Lianmei Wang Hongbing Zhang Chunying Li Yan Yi Jing Liu Yong Zhao Jingzhuo Tian Yushi Zhang Xiaolu Wei Yue Gao Aihua Liang Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity. PLoS ONE |
| title | Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity. |
| title_full | Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity. |
| title_fullStr | Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity. |
| title_full_unstemmed | Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity. |
| title_short | Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity. |
| title_sort | omeprazole alleviates aristolochia manshuriensis kom induced acute nephrotoxicity |
| url | http://europepmc.org/articles/PMC5055352?pdf=render |
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