Differential distribution of major brain gangliosides in the adult mouse central nervous system.
Gangliosides - sialic acid-bearing glycolipids - are major cell surface determinants on neurons and axons. The same four closely related structures, GM1, GD1a, GD1b and GT1b, comprise the majority of total brain gangliosides in mammals and birds. Gangliosides regulate the activities of proteins in t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3787110?pdf=render |
| _version_ | 1798045413512577024 |
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| author | Katarina Vajn Barbara Viljetić Ivan Večeslav Degmečić Ronald L Schnaar Marija Heffer |
| author_facet | Katarina Vajn Barbara Viljetić Ivan Večeslav Degmečić Ronald L Schnaar Marija Heffer |
| author_sort | Katarina Vajn |
| collection | DOAJ |
| description | Gangliosides - sialic acid-bearing glycolipids - are major cell surface determinants on neurons and axons. The same four closely related structures, GM1, GD1a, GD1b and GT1b, comprise the majority of total brain gangliosides in mammals and birds. Gangliosides regulate the activities of proteins in the membranes in which they reside, and also act as cell-cell recognition receptors. Understanding the functions of major brain gangliosides requires knowledge of their tissue distribution, which has been accomplished in the past using biochemical and immunohistochemical methods. Armed with new knowledge about the stability and accessibility of gangliosides in tissues and new IgG-class specific monoclonal antibodies, we investigated the detailed tissue distribution of gangliosides in the adult mouse brain. Gangliosides GD1b and GT1b are widely expressed in gray and white matter. In contrast, GM1 is predominately found in white matter and GD1a is specifically expressed in certain brain nuclei/tracts. These findings are considered in relationship to the hypothesis that gangliosides GD1a and GT1b act as receptors for an important axon-myelin recognition protein, myelin-associated glycoprotein (MAG). Mediating axon-myelin interactions is but one potential function of the major brain gangliosides, and more detailed knowledge of their distribution may help direct future functional studies. |
| first_indexed | 2024-04-11T23:20:28Z |
| format | Article |
| id | doaj.art-e1c150cbaa9e44c28f98e6d57bd1db2a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T23:20:28Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e1c150cbaa9e44c28f98e6d57bd1db2a2022-12-22T03:57:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7572010.1371/journal.pone.0075720Differential distribution of major brain gangliosides in the adult mouse central nervous system.Katarina VajnBarbara ViljetićIvan Večeslav DegmečićRonald L SchnaarMarija HefferGangliosides - sialic acid-bearing glycolipids - are major cell surface determinants on neurons and axons. The same four closely related structures, GM1, GD1a, GD1b and GT1b, comprise the majority of total brain gangliosides in mammals and birds. Gangliosides regulate the activities of proteins in the membranes in which they reside, and also act as cell-cell recognition receptors. Understanding the functions of major brain gangliosides requires knowledge of their tissue distribution, which has been accomplished in the past using biochemical and immunohistochemical methods. Armed with new knowledge about the stability and accessibility of gangliosides in tissues and new IgG-class specific monoclonal antibodies, we investigated the detailed tissue distribution of gangliosides in the adult mouse brain. Gangliosides GD1b and GT1b are widely expressed in gray and white matter. In contrast, GM1 is predominately found in white matter and GD1a is specifically expressed in certain brain nuclei/tracts. These findings are considered in relationship to the hypothesis that gangliosides GD1a and GT1b act as receptors for an important axon-myelin recognition protein, myelin-associated glycoprotein (MAG). Mediating axon-myelin interactions is but one potential function of the major brain gangliosides, and more detailed knowledge of their distribution may help direct future functional studies.http://europepmc.org/articles/PMC3787110?pdf=render |
| spellingShingle | Katarina Vajn Barbara Viljetić Ivan Večeslav Degmečić Ronald L Schnaar Marija Heffer Differential distribution of major brain gangliosides in the adult mouse central nervous system. PLoS ONE |
| title | Differential distribution of major brain gangliosides in the adult mouse central nervous system. |
| title_full | Differential distribution of major brain gangliosides in the adult mouse central nervous system. |
| title_fullStr | Differential distribution of major brain gangliosides in the adult mouse central nervous system. |
| title_full_unstemmed | Differential distribution of major brain gangliosides in the adult mouse central nervous system. |
| title_short | Differential distribution of major brain gangliosides in the adult mouse central nervous system. |
| title_sort | differential distribution of major brain gangliosides in the adult mouse central nervous system |
| url | http://europepmc.org/articles/PMC3787110?pdf=render |
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