Gut Microbiota and Obesity: The Chicken or the Egg?
Although the link between gut microbiota and obesity is increasingly reported, the pathophysiological mechanisms and clinical outcomes are still under debate. This overview of human and animal data addresses several pathophysiologic mechanisms, dietary habits, exercise and probiotic and symbiotic su...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Obesities |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4168/3/4/24 |
| _version_ | 1797379813547180032 |
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| author | Daniele S. Tassoni Rodrigo C. O. Macedo Felipe M. Delpino Heitor O. Santos |
| author_facet | Daniele S. Tassoni Rodrigo C. O. Macedo Felipe M. Delpino Heitor O. Santos |
| author_sort | Daniele S. Tassoni |
| collection | DOAJ |
| description | Although the link between gut microbiota and obesity is increasingly reported, the pathophysiological mechanisms and clinical outcomes are still under debate. This overview of human and animal data addresses several pathophysiologic mechanisms, dietary habits, exercise and probiotic and symbiotic supplementation in the fields of gut microbiota and obesity. Overall, obesity impairs gut microbiota composition due to factors that may be linked to the onset of the disease, such as excessive consumption of high-energy foods, sugars and fats, as well as a low fiber intake and physical inactivity. Conversely, low-energy diets, physical exercise, and probiotic and prebiotic supplementations can enhance gut microbiota in patients with obesity, in addition to improving cardiometabolic markers. As for perspectives, further research is warranted to ascertain proper dietary manipulation, physical exercise protocols and dosing regimens of probiotics. Regarding the latter, the effects on indicators of obesity are clinically modest, and hence skepticism must be exercised. |
| first_indexed | 2024-03-08T20:28:28Z |
| format | Article |
| id | doaj.art-e1c16e461c41475da4a02b4090a7d346 |
| institution | Directory Open Access Journal |
| issn | 2673-4168 |
| language | English |
| last_indexed | 2024-03-08T20:28:28Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Obesities |
| spelling | doaj.art-e1c16e461c41475da4a02b4090a7d3462023-12-22T14:30:22ZengMDPI AGObesities2673-41682023-11-013429632110.3390/obesities3040024Gut Microbiota and Obesity: The Chicken or the Egg?Daniele S. Tassoni0Rodrigo C. O. Macedo1Felipe M. Delpino2Heitor O. Santos3Department of Health Sciences, Universidade de Santa Cruz do Sul (UNISC), Av. Independência, 2293-Universitário, Santa Cruz do Sul 96815-900, BrazilDepartment of Health Sciences, Universidade de Santa Cruz do Sul (UNISC), Av. Independência, 2293-Universitário, Santa Cruz do Sul 96815-900, BrazilPostgraduate Program in Nursing, Universidade Federal de Pelotas (UFPEL), R. Gomes Carneiro, 01-Balsa, Pelotas 96010-610, BrazilPostgraduate Program, Faculdade UNIGUAÇU, EXXA Building—Pres. Bernardes Street, 2009—2nd Floor—Center, Cascavel 85801-180, BrazilAlthough the link between gut microbiota and obesity is increasingly reported, the pathophysiological mechanisms and clinical outcomes are still under debate. This overview of human and animal data addresses several pathophysiologic mechanisms, dietary habits, exercise and probiotic and symbiotic supplementation in the fields of gut microbiota and obesity. Overall, obesity impairs gut microbiota composition due to factors that may be linked to the onset of the disease, such as excessive consumption of high-energy foods, sugars and fats, as well as a low fiber intake and physical inactivity. Conversely, low-energy diets, physical exercise, and probiotic and prebiotic supplementations can enhance gut microbiota in patients with obesity, in addition to improving cardiometabolic markers. As for perspectives, further research is warranted to ascertain proper dietary manipulation, physical exercise protocols and dosing regimens of probiotics. Regarding the latter, the effects on indicators of obesity are clinically modest, and hence skepticism must be exercised.https://www.mdpi.com/2673-4168/3/4/24overweightmicrobiomedietphysical activityprobioticdysbiosis |
| spellingShingle | Daniele S. Tassoni Rodrigo C. O. Macedo Felipe M. Delpino Heitor O. Santos Gut Microbiota and Obesity: The Chicken or the Egg? Obesities overweight microbiome diet physical activity probiotic dysbiosis |
| title | Gut Microbiota and Obesity: The Chicken or the Egg? |
| title_full | Gut Microbiota and Obesity: The Chicken or the Egg? |
| title_fullStr | Gut Microbiota and Obesity: The Chicken or the Egg? |
| title_full_unstemmed | Gut Microbiota and Obesity: The Chicken or the Egg? |
| title_short | Gut Microbiota and Obesity: The Chicken or the Egg? |
| title_sort | gut microbiota and obesity the chicken or the egg |
| topic | overweight microbiome diet physical activity probiotic dysbiosis |
| url | https://www.mdpi.com/2673-4168/3/4/24 |
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